Volume 7 (1991) Issue 1 - Issue 6 | Analytical and quantitative cytology and histology

Volume 7 (1991) Issue 1 - Issue 6

L G Koss, M Bibbo, D L Rosenthal
George L. Wied--seventy years young
Editorial: 1991 Feb;13(1):1-2
A M van Ginneken, A W Smeulders
Reasoning in uncertainties. An analysis of five strategies and their suitability in pathology
Review: 1991 Apr;13(2):93-109
Abstract: In reasoning systems, uncertainty plays a crucial part, especially for those fields in which judgements are essential, as in pathology. Uncertainty has several aspects, such as prevalence of diseases, occurrence of findings and the sensitivity and predictive value of findings.
A M Marchevsky
Expert systems for efficient handling of medical information. I. Lung cancer
Review: 1991 Apr;13(2):89-92
Abstract: Rule-based expert systems offer the ability to quickly retrieve considerable amounts of information relevant to specific situations; the technology can be potentially very useful to physicians in an era characterized by an explosion of medical data.
A Nikkels, T Ben Mosbah, C Piérard-Franchimont, M de la Brassinne, G E Piérard
Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin
Comparative Study: 1991 Feb;13(1):23-6
Abstract: Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines).
R J Sokol, J Wales, G Hudson 2nd, D Goldstein, N T James
Cellular dry mass during macrophage development in malignant lymphoma
1991 Dec;13(6):379-82
Abstract: In order to throw light on known mononuclear phagocyte disturbances in malignant lymphoma, scanning and integrating microinterferometry was employed to measure dry mass in developing mononuclear phagocytes after 0, 2, 4 and 6 days of suspension culture, using cells from 19 healthy subjects, 19 patients with Hodgkin's disease and 17 with non-Hodgkin's lymphoma.
J G Cowpe, M W Green, G R Ogden
Quantitative cytology of oral smears. A comparison of two methods of measurement
Comparative Study: 1991 Feb;13(1):11-5
Abstract: Previous quantitative cytologic studies employing planimetry to assess oral smears established a "discriminant line" for separating normal and abnormal cases.
E T Mystkowska, A Komar, P Strojny, M Rozycka, W Sawicki
Fourier analysis of the nuclear and cytoplasmic shapes of living two-cell murine embryos
1991 Jun;13(3):209-14
Abstract: Living two-cell mouse embryos were flushed out from the oviduct 17, 24 and 36 hours after fertilization in order to obtain cells in the G1S, early G2 and late G2 phases of the second cell cycle.
D J Foran, F Cahn, E F Eikenberry
Assessment of cell proliferation on porous microcarriers by means of image analysis
1991 Jun;13(3):215-22
Abstract: Spherical porous microcarriers (PMCs) made from collagen-glycosaminoglycan crosslinked copolymers have exhibited considerable promise as growth surfaces for the proliferation of anchorage-dependent mammalian cell lines and have demonstrated the ability to entrap anchorage-independent cells.
S J Lockett, M O'Rand, C A Rinehart, D G Kaufman, B Herman, K Jacobson
Automated fluorescence image cytometry. DNA quantification and detection of chlamydial infections
Comparative Study: 1991 Feb;13(1):27-44
Abstract: Digitized fluorescence microscopy in conjunction with automated image segmentation is a promising approach for screening clinical specimens quickly and reliably. This paper describes the hardware and software of a prototype image-based cytometer that can identify fluorescent objects, discriminate true objects from artifacts and divide overlapping pairs of objects.
F Van Meir
Planimetry of bronchoalveolar macrophages. Importance of preparation and staining techniques
1991 Aug;13(4):261-8
Abstract: Bronchoalveolar lavage seems a well-established, valuable research tool in the study of alveolar macrophages. The influence of fixation, cytocentrifugation and staining procedures on the cellular and nuclear size has been investigated by planimetry.
M Delverdier, P Cabanie, N Roome, F Enjalbert, G van Haverbeke
Quantitative histology of the rat thyroid. Influence of histologic techniques on the morphometric data
1991 Apr;13(2):110-4
Abstract: The influence of various histologic techniques on the results obtained by morphometric analysis of the rat thyroid gland was studied.
V Björnhagen, G Auer, B Lagerlöf, K Erhardt, E Månsson-Brahme
Nuclear DNA analyses in archival material from primary malignant melanoma. A pilot study
1991 Oct;13(5):335-42
Abstract: In 28 cases of malignant melanoma, paraffin-embedded specimens were analyzed in order to determine the reliability of ploidy results. The material consisted of thin and thick melanomas.
B Eriksen, D S Miller, T M Murad, J R Lurain, K D Bauer
Dual-parameter flow cytometric analysis coupling the measurements of forward-angle light scatter and DNA content of archival ovarian carcinomas of low malignant potential
1991 Feb;13(1):45-53
Abstract: Paraffin-embedded archival specimens from 45 cases of ovarian carcinoma of low malignant potential (OCLMP) were analyzed by flow cytometry (FCM) using propidium iodide (PI) staining. Since single-parameter FCM analysis is often deficient in the resolution of subtle near-diploid DNA-aneuploid populations, forward-angle light scatter (FALS) was measured as a second parameter.
C B Finn, K Ward, D M Luesley, J A Dunn, C W Redman
Qualitative and quantitative analysis of peritoneal fluids from women with gynecologic diseases. Comparison of cytology and flow cytometry for the detection of malignancy in lavage and ascitic fluids
1991 Jun;13(3):182-6
Abstract: A prospective study was undertaken to compare flow cytometric (FCM) analysis to conventional cytologic evaluation for the detection of malignant cells in peritoneal fluids (peritoneal lavages and ascitic fluids) from women with gynecologic diseases.
M Dictor, M Fernö, B Baldetorp
Flow cytometric DNA content in Kaposi's sarcoma by histologic stage. Comparison with angiosarcoma
Comparative Study: 1991 Jun;13(3):201-8
Abstract: Kaposi's sarcoma occurs as a multicentric proliferation of endothelial cells. A lesion may progress through several histologic stages, culminating in a lesion consisting of spindle cells with marked nuclear atypia that may be indistinguishable from angiosarcoma.
I Ishiwata, C Ishiwata, M Soma, H Akagi, H Hiyama, T Nakaguchi, I Ono, H Hashimoto, H Ishikawa
Presence of human papillomavirus genome in human tumor cell lines and cultured cells
1991 Oct;13(5):363-70
Abstract: A series of 47 human carcinoma cell lines and their cultured cells were examined for human papillomavirus (HPV) genomes with the use of an HPV detection kit (DNA-RNA hybridization, mixed HPV DNA probe of types 6, 11, 16, 18, 31, 33 and 35).
U V Mikel, R L Becker Jr
A comparative study of quantitative stains for DNA in image cytometry
Comparative Study: 1991 Aug;13(4):253-60
Abstract: In this study we examined the reproducibility of several stains used to measure nuclear DNA by image cytometry. The specimens were touch preparations of liver and testis from mouse and liver, intestine and brain from rat, fixed in either neutral formalin or Carnoy's solution.
R C Leif, I D Rosello, D M Simler, G P Garcia, S B Leif
Ada software for cytometry
Comparative Study: 1991 Dec;13(6):440-50
Abstract: Ada is a new general-purpose language that embodies the concepts of software engineering. Although it was initially developed for military purposes, it is suitable for developing software for cytometry and other health-related applications.
J J Berman, J D Seidman, R Yetter, G W Moore
Clear cell dysplasia of the bladder. Report of a case with flow cytometric analysis
Case Reports: 1991 Dec;13(6):391-4
Abstract: Clear cell dysplasia of the bladder is a well-described morphologic entity that has been found in association with transitional cell carcinoma of the bladder. Its biologic role in bladder tumorigenesis is unknown, and no instances of its polidy analysis have been reported.
N B Atkin
The clinical usefulness of determining ploidy patterns in human tumors as measured by slide-based Feulgen microspectrophotometry
1991 Apr;13(2):75-9
Abstract: Some aspects of the clinical value of the Feulgen microspectrophotometric assessment of DNA ploidy patterns in human tumors are reviewed. This method has been shown to be of predictive value for a number of tumor sites and may be independent of other prognostic indicators, such as the histopathologic grade.
R Kiss, D Larsimont, A G Huvos
Digital cell image analysis of Ewing's sarcoma
1991 Oct;13(5):356-62
Abstract: We analyzed the lesional tissue in Ewing's sarcoma by means of a cell image processor computing 15 nuclear parameters in order to quantify the morphologic variability of the tumor cell nuclei.
R A Ambros
Reproducibility of nuclear morphometric measurements in benign human epithelial cells. Simulation of variations in routine tissue processing
Comparative Study: 1991 Dec;13(6):407-10
Abstract: The value of nuclear morphometric measurements in diagnostic pathology is determined largely by the reproducibility of the measurements. Although a variety of factors have been shown to affect tissues during processing, the regulation of fixative type and the avoidance of air drying in particular have been shown to avoid significant variations in nuclear measurements.
J Aferzon, R I Chau, D F Cowan
A microcomputer-based system for three-dimensional reconstructions from tomographic or histologic sections
1991 Apr;13(2):80-8
Abstract: The reconstructions of three-dimensional (3-D) objects from serial two-dimensional (2-D) images can contribute to the understanding of many biologic structures, from organelles to organs and tissues.
L J Brindza
FDA regulation of computerized cytology devices
1991 Feb;13(1):3-6
Abstract: When talking about computerized cytology devices, a "different" aspect of quality assurance must be addressed.
A M Uyterlinde, A W Smeulders, J P Baak
DNA measurement errors with a scanning microdensitometer in cytologic and histologic samples of breast cancers
1991 Apr;13(2):115-22
Abstract: The influence of various DNA measurement errors using a commercially available scanning microdensitometer was evaluated on Feulgen-stained cytologic and histologic samples prepared from paraffin blocks containing invasive ductal breast cancers.
R González-Cámpora, F J González de Chaves, J Mora-Marin, R Rodriguez-González, J C Utrilla-Alcolea, J Rubí-Uría, H Galera-Davidson
Nuclear planimetry in renal-cell tumors
1991 Feb;13(1):54-60
Abstract: A morphometric study using conventional planimetry was carried out in 73 renal-cell tumors (64 adenocarcinomas and 9 adenomas) in order to correlate the objective nuclear measurements with some histologic and clinical data believed to have prognostic value.
J P Rigaut, J Vassy
High-resolution three-dimensional images from confocal scanning laser microscopy. Quantitative study and mathematical correction of the effects from bleaching and fluorescence attenuation in depth
1991 Aug;13(4):269-78
Abstract: Three-dimensional images can be assembled by piling up consecutive confocal fluorescent images obtained by confocal scanning laser microscopy.
M Bibbo, D H Kim, T Pfeifer, H E Dytch, H Galera-Davidson, P H Bartels
Histometric features for the grading of prostatic carcinoma
1991 Feb;13(1):61-8
Abstract: Histometric features for the objective grading of prostatic adenocarcinoma in histologic specimens were analyzed in five cases each of well, moderately and poorly differentiated lesions. Tissue sections from the selected cases were stained by the Feulgen method and digitized by a video-based microphotometer.
N W Schipper, J P Baak, A W Smeulders
Automated selection of the most epithelium-rich areas in gynecologic tumor sections
Comparative Study: 1991 Dec;13(6):395-402
Abstract: The paper describes an image analysis technique for automated selection of the epithelium-rich areas in standard paraffin tissue sections of ovarian and endometrial premalignancies and malignancies.
X Pasteur, O Sabido, I Maubon, M Perrin-Cottier, J L Laurent
Quantitative assessment of chromatin stability alteration in human spermatozoa induced by freezing and thawing. A flow cytometric study
1991 Dec;13(6):383-90
Abstract: The authors examined the effect of cryopreservation on chromatin stability in human spermatozoa from 21 ejaculates.
I Salmon, M Coibion, D Larsimont, A Badr-el-Din, A Verhest, J L Pasteels, R Kiss
Comparison of fine needle aspirates of breast cancers to imprint smears by means of digital cell image analysis
Comparative Study: 1991 Jun;13(3):193-200
Abstract: Morphonuclear assessments were performed using the SAMBA 2005 cell image processor on cell nuclei in fine needle aspirates and corresponding imprint smears from 17 not-otherwise-specified (NOS) breast carcinomas to study the influence of cell sampling on the morphonuclear measurements.
H G van der Poel, M E Boon, L P Kok, E A van der Meulen, R D van Caubergh, W C de Bruijn, F M Debruyne
Morphometry, densitometry and pattern analysis of plastic-embedded histologic material from urothelial cell carcinoma of the bladder
1991 Oct;13(5):307-15
Abstract: An image analysis method of grading histologic sections of bladder carcinoma was tested. The method was new in four respects.
T C Chang, S H Kuo, S W How
Coefficient of variation of nuclear diameters as a prognostic factor in papillary thyroid carcinoma
1991 Dec;13(6):403-6
Abstract: To determine whether the coefficient of variation (CV) of nuclear diameters can be used as a prognostic factor in papillary thyroid carcinoma, we reviewed fine needle aspiration smears with Riu's stain from 55 operated-on and pathologically verified cases with a median follow-up of 6.5 years.
M Oberholzer, H Christen, R Ettlin, M Buser, M Oestreicher, R Gschwind
Some fundamental aspects of morphometry in clinical pathology, demonstrated on a simple, multipurpose analysis system
1991 Oct;13(5):316-20
Abstract: The aim of this study was (1) to investigate the value of morphometry, (2) to fix a set of parameters suitable for analyzing diagnostic problems, and (3) to create a general strategy for data storage and for user-friendly data management.
D W Visscher, S Wykes, R J Zarbo, J D Crissman
Multiparametric evaluation of flow cytometric synthesis phase fraction determination in dual-labelled breast carcinomas
1991 Aug;13(4):246-52
Abstract: Multiparametric, two-color DNA and cell cycle analyses were performed on 112 consecutive mechanically dissociated, ethanol-fixed breast carcinomas using a dual-label method with monoclonal antibodies (CAM 5.2) to cytokeratin (CK) and leukocyte common antigen (LCA) with propidium iodide (PI) staining.
M Koha, B Wikström, B Brismar
DNA distribution pattern in colorectal carcinoma. A methodologic study comparing two different biopsy techniques
1991 Dec;13(6):429-32
Abstract: DNA content was measured in 59 samples from 20 colorectal adenocarcinomas and 5 adenomas by single cell microspectrophotometry.
D H Char, S M Kroll, A Stoloff, S Kaleta-Michaels, J B Crawford, T R Miller, E L Howes Jr, B M Ljung
Cytomorphometry of uveal melanoma. Comparison of fine needle aspiration biopsy samples with histologic sections
Comparative Study: 1991 Aug;13(4):293-9
Abstract: A number of approaches are being investigated to increase the prognostic accuracy for uveal melanoma patients; the standard deviation of nucleolar area measurements and the DNA content appear to correlate better with survival than do classic histologic parameters.
J Lubínski, K Ptaszynski, Y Tsujimoto, K Huebner, C Croce
Germ line configuration of the BCL-2 major breakpoint region in hyperplastic lymph nodes
Comparative Study: 1991 Dec;13(6):425-8
Abstract: The configuration of the BCL-2 major breakpoint region was analyzed by Southern blot hybridization and polymerase chain reaction amplification in DNA derived from 44 benign hyperplastic lymph nodes with follicular overgrowth.
M McLean, J W Prothero
Three-dimensional reconstruction from serial sections. V. Calibration of dimensional changes incurred during tissue preparation and data processing
1991 Aug;13(4):269-78
Abstract: Three-dimensional (3-D) reconstructions from serial tissue sections produce a table of x, y, z coordinates (i.e., a numerical description of the object) that will support 3-D computer graphics displays and morphometric analyses.
A Hijazi, M Devonec, R Bouvier, P P Bringuier, J P Revillard
Use of leukocytes infiltrating bladder tumors as an internal reference for determining the DNA index by flow cytometry
Comparative Study: 1991 Apr;13(2):139-42
Abstract: The use of leukocytes infiltrating bladder tumors as an internal standard for flow cytometric measurements of DNA and SG2M indices was investigated in comparison with the conventional use of chicken erythrocytes (chicken red blood cells; CRBC).
S Caulet, C Lesty, M Raphael, J L Binet, J Diebold
Quantitative study of KI-67 antibody staining in non-Hodgkin's lymphomas using image analysis
1991 Aug;13(4):279-87
Abstract: In sections from 32 B malignant lymphomas (ML), the total KI-67 stained area was compared to the number of KI-67 positive cells in order to demonstrate the reliability of using image analysis to quantify the proliferative activity.
V Cavallari, A Maiorana, M C Maiorana, R A Fano, S Scimone, G P Trentini
A morphometric comparison of subcellular structures between primary breast tumors and their nodal metastases
Comparative Study: 1991 Apr;13(2):123-31
Abstract: A morphometric study of subcellular structures in human primary breast tumors (of the ductal infiltrating type) and their synchronous lymph node metastases was carried out using planimetry and stereology.
M L Hutchinson, L M Isenstein, D J Zahniser
High-resolution and contextual analysis for the diagnosis of fine needle aspirates of breast
Comparative Study: 1991 Oct;13(5):351-5
Abstract: A study was undertaken to confirm earlier work on a smaller number of patients that had suggested that medium-resolution contextual analysis complements high-resolution individual cell analysis for cytomorphometric classification of fine needle aspirate smears of breast.
L J Layfield, N S Goldstein
Morphometric analysis of borderline atypia in prostatic aspiration biopsy specimens
Comparative Study: 1991 Aug;13(4):288-92
Abstract: In a prior study of 411 fine needle aspirates of the prostate (FNAPs), we identified a subset of 50 (12%) aspirates in which the findings were designated cytologically atypical.
H Ullén, U G Falkmer, V P Collins, G U Auer
Methodologic aspects of nuclear DNA assessment of gliomas with astrocytic and/or oligodendrocytic differentiation. Correlation of image and flow cytometric studies on paraffin-embedded specimens
1991 Jun;13(3):168-76
Abstract: A total of 239 samples from paraffin-embedded, formalin-fixed astrocytic and/or oligodendrocytic gliomas from 111 patients were deparaffinized and disaggregated for image cytometric (ICM) and flow cytometric (FCM) DNA assessments.
J D Crissman, S Drozdowicz, C Johnson, S R Kini
Fine needle aspiration diagnosis of hyperplastic and neoplastic follicular nodules of the thyroid. A morphometric study
1991 Oct;13(5):321-8
Abstract: The differentiation of hyperplastic nodules, follicular adenomas and follicular carcinomas from fine needle aspiration (FNA) cytology smears may be difficult.
M Perrin-Cottier, C Jouffre, O Sabido, I Maubon, C Barthélémy, X Pasteur, J C Audigier, J L Laurent
Flow cytometric analysis of DNA content in colorectal polyps resected at endoscopy
1991 Apr;13(2):75-9
Abstract: Samples from 64 consecutive resected colorectal polyps were preserved in liquid nitrogen and analyzed by flow cytometry to assess the nuclear DNA content, which was compared to the histopathologic findings.
D W Visscher, F H Sarkar, J D Crissman
Correlation of DNA ploidy with c-erbB-2 expression in preinvasive and invasive breast tumors
Comparative Study: 1991 Dec;13(6):418-24
Abstract: Detection of c-erbB-2 oncogene product expression by monoclonal antibody staining (avidin-biotin technique) in formalin-fixed, paraffin-embedded atypical hyperplasias (AH, n = 20), intraductal carcinomas (IDCA, n = 27) and invasive carcinomas (INVCA, n = 48) was compared to ploidy determinations obtained by flow cytometry (INVCA) or image analysis (AH, IDCA).
A G Montag, P H Bartels, H E Dytch, E Lerma-Puertas, F Michelassi, M Bibbo
Karyometric features in nuclei near colonic adenocarcinoma. Statistical analysis ?
1991 Jun;13(3):159-67
Abstract: The normal mucosa adjacent to colonic adenocarcinoma (marginal or transitional mucosa) has been shown to have subtle alterations of architecture, surface glycoproteins and proliferative activity.
C Minimo, P H Bartels, D H Kim, T Pfeifer, H E Dytch, H Galera-Davidson, M Bibbo
Value of the cribriformity factor in grading prostatic carcinoma
1991 Dec;13(6):411-7
Abstract: Architectural and histometric features for the objective grading of prostate adenocarcinoma in histologic specimens were analyzed in five cases each of Gleason primary grades 2, 3A, 3B, 3C, 4A and 4B, selected as "typical" for the histopathologic images.
L Kapusta, I Zbieranowski, C Demianiuk, D Murray
The role of DNA flow and image cytometry in the evaluation of body cavity fluids
1991 Jun;13(3):187-92
Abstract: In addition to conventional cytomorphologic study, 50 body cavity fluid specimens (benign and malignant) were analyzed by both flow cytometry (FCM) and image cytometry (ICM) in order to evaluate the potential application of these techniques in the diagnosis of malignancy.
C A Rubio, A Porwit-McDonald
A method to quantitate the relative nuclear area of colorectal polyps by image analysis
1991 Jun;13(3):155-8
Abstract: Image analysis of the nuclear area was performed on Feulgen-stained sections from 94 colorectal polyps: 57 colorectal adenomas with or without invasive growth, 28 hyperplastic polyps and 9 Peutz-Jeghers hamartomas (without dysplasia or carcinoma).
H Beerman, R W Veldhuizen, R A Blok, J Hermans, E C Ooms
Cytomorphometry as quality control for fine needle aspiration. A study in 321 breast lesions
1991 Apr;13(2):143-8
Abstract: Material collected by fine needle aspiration (FNA) in 321 histologically examined primary breast lesions of previously untreated patients was analyzed by morphometry. The mean nuclear area (MNA) and its standard deviation (SD) were calculated for 50 cells in each case.
R González-Cámpora, J R Armas-Padrón, J J Rios-Martín, J López-Garrido, A Gómez-Pascual, H Galera-Davidson
Nucleolar organizer regions in pigmented skin lesions. Value in the differential diagnosis of Spitz nevi
1991 Feb;13(1):16-22
Abstract: Forty-one cases of typical melanocytic skin lesions (15 intradermal nevi, 14 Spitz nevi and 12 malignant melanomas) were used to investigate the value of staining of nucleolar organizer regions (NORs) in the differential diagnosis of such pigmented lesions.
No authors listed
Data on automated cytology systems as submitted by their developers
Comparative Study: 1991 Aug;13(4):300-6
S Biesterfeld, L Füzesi, F Härle, A Böcking
DNA-cytometric detection of euploid polyploidization in oral lichen ruber planus
1991 Feb;13(1):7-10
Abstract: The DNA distribution was analyzed in 29 cases of oral lichen ruber planus that were negative for human papillomavirus and not suspected of being precancerous.
A Heimann, H Cramer, S Patel, H G Gratzner, R L Katz
Determination of the rate of DNA synthesis of human tumor cells obtained by fine needle aspiration. Comparison of flow cytometry and an immunoperoxidase method for the detection of thymidine analogue incorporation
1991 Oct;13(5):371-8
Abstract: Two methods of detecting thymidine analogue incorporation by lymphoma, leukemia and myeloma cells obtained by fine needle aspiration (FNA) are described.
R Rondez, C Yoshizaki, W Pirozynski
Determination of nuclear DNA content and hormone receptors in breast cancer by the CAS 100 cell analysis system as related to morphologic grade and biochemical results
1991 Aug;13(4):233-45
Abstract: Quantitative DNA analysis by the CAS 100 Cell Analysis System was performed on 120 cases of primary breast carcinoma using touch preparations from fresh biopsy specimens in 110 cases and archival, restrained fine needle preparations in 10 cases.
C Cohen, R A Santoianni, R J Tickman, J C Kennedy, P B DeRose
Semiautomation of preparation of fixed paraffin-embedded tissue for DNA analysis
1991 Jun;13(3):177-81
Abstract: The usual manual preparation of single-cell suspensions from fixed paraffin-embedded tissue sections for flow cytometric (FCM) DNA ploidy analysis is a time-consuming, labor-intensive technique that requires 70 minutes to deparaffinize and rehydrate 50 microns sections as the initial step.
V Björnhagen, K Erhardt, B Lagerlöf, G Auer
Comparison of nuclear DNA content in primary and metastatic malignant melanoma
Comparative Study: 1991 Oct;13(5):343-50
Abstract: The DNA patterns obtained from 23 primary malignant melanomas and 35 corresponding metastases were compared and found to differ in many cases. In eight cases the primary tumors and their metastases had a ploidy type I ("euploid") DNA pattern.
K Ptaszynski, J Podolski, K Huebner, J Lubinski
Gene rearrangements detected by nonradioactive digoxigenin-labeled DNA probes
1991 Jun;13(3):149-54
Abstract: The configurations of immunoglobulin, T-cell receptor beta chain and bcl-2 genes were analyzed in lympho-proliferative disorders using nonradioactive digoxigenin-labeled probes.
M S Wachtel, D J Zahniser, A E Rogers, M L Hutchinson
Automated analysis of rat breast tumors. Comparison of four methods
Comparative Study: 1991 Feb;13(1):69-73
Abstract: Chemically-induced malignant rat breast tumors pose diagnostic dilemmas since the majority are well-differentiated, noninvasive papillary lesions that are barely distinguishable from benign papillary lesions.
J D Crissman, S Drozdowicz, C Johnson, S R Kini
Fine needle aspiration diagnosis of hyperplastic and neoplastic follicular nodules of the thyroid. A morphometric study
1991 Oct;13(5):321-8
Abstract: The differentiation of hyperplastic nodules, follicular adenomas and follicular carcinomas from fine needle aspiration (FNA) cytology smears may be difficult.
M Perrin-Cottier, C Jouffre, O Sabido, I Maubon, C Barthélémy, X Pasteur, J C Audigier, J L Laurent
Flow cytometric analysis of DNA content in colorectal polyps resected at endoscopy
1991 Apr;13(2):75-9
Abstract: Samples from 64 consecutive resected colorectal polyps were preserved in liquid nitrogen and analyzed by flow cytometry to assess the nuclear DNA content, which was compared to the histopathologic findings.
D W Visscher, F H Sarkar, J D Crissman
Correlation of DNA ploidy with c-erbB-2 expression in preinvasive and invasive breast tumors
Comparative Study: 1991 Dec;13(6):418-24
Abstract: Detection of c-erbB-2 oncogene product expression by monoclonal antibody staining (avidin-biotin technique) in formalin-fixed, paraffin-embedded atypical hyperplasias (AH, n = 20), intraductal carcinomas (IDCA, n = 27) and invasive carcinomas (INVCA, n = 48) was compared to ploidy determinations obtained by flow cytometry (INVCA) or image analysis (AH, IDCA).
A G Montag, P H Bartels, H E Dytch, E Lerma-Puertas, F Michelassi, M Bibbo
Karyometric features in nuclei near colonic adenocarcinoma. Statistical analysis ?
1991 Jun;13(3):159-67
Abstract: The normal mucosa adjacent to colonic adenocarcinoma (marginal or transitional mucosa) has been shown to have subtle alterations of architecture, surface glycoproteins and proliferative activity.
C Minimo, P H Bartels, D H Kim, T Pfeifer, H E Dytch, H Galera-Davidson, M Bibbo
Value of the cribriformity factor in grading prostatic carcinoma
1991 Dec;13(6):411-7
Abstract: Architectural and histometric features for the objective grading of prostate adenocarcinoma in histologic specimens were analyzed in five cases each of Gleason primary grades 2, 3A, 3B, 3C, 4A and 4B, selected as "typical" for the histopathologic images.
L Kapusta, I Zbieranowski, C Demianiuk, D Murray
The role of DNA flow and image cytometry in the evaluation of body cavity fluids
1991 Jun;13(3):187-92
Abstract: In addition to conventional cytomorphologic study, 50 body cavity fluid specimens (benign and malignant) were analyzed by both flow cytometry (FCM) and image cytometry (ICM) in order to evaluate the potential application of these techniques in the diagnosis of malignancy.
C A Rubio, A Porwit-McDonald
A method to quantitate the relative nuclear area of colorectal polyps by image analysis
1991 Jun;13(3):155-8
Abstract: Image analysis of the nuclear area was performed on Feulgen-stained sections from 94 colorectal polyps: 57 colorectal adenomas with or without invasive growth, 28 hyperplastic polyps and 9 Peutz-Jeghers hamartomas (without dysplasia or carcinoma).
H Beerman, R W Veldhuizen, R A Blok, J Hermans, E C Ooms
Cytomorphometry as quality control for fine needle aspiration. A study in 321 breast lesions
1991 Apr;13(2):143-8
Abstract: Material collected by fine needle aspiration (FNA) in 321 histologically examined primary breast lesions of previously untreated patients was analyzed by morphometry. The mean nuclear area (MNA) and its standard deviation (SD) were calculated for 50 cells in each case.
R González-Cámpora, J R Armas-Padrón, J J Rios-Martín, J López-Garrido, A Gómez-Pascual, H Galera-Davidson
Nucleolar organizer regions in pigmented skin lesions. Value in the differential diagnosis of Spitz nevi
1991 Feb;13(1):16-22
Abstract: Forty-one cases of typical melanocytic skin lesions (15 intradermal nevi, 14 Spitz nevi and 12 malignant melanomas) were used to investigate the value of staining of nucleolar organizer regions (NORs) in the differential diagnosis of such pigmented lesions.

Volume 7 (1991) Issue 1 - Issue 6

AQCH

Information

Make a Submission

Developed By

Browse