Volume 4 (1988) Issue 1 - Issue 6

 

  • T S Johnson, R L Katz, M Pershouse
    Flow cytometric applications in cytopathology
    Review: 1988 Dec;10(6):423-58.
    Abstract: Flow cytometric (FCM) methodology represents a powerful analytical tool for screening and detecting abnormal and malignant cells, for subclassifying malignancies beyond conventional morphologic type and grade and for transcending light microscopic features by providing more biologically meaningful information.
  • A P Dhawan
    An expert system for the early detection of melanoma using knowledge-based image analysis
    Review: 1988 Dec;10(6):405-16.
    Abstract: Melanoma is the most lethal skin cancer; however, nearly all patients can be saved and cured by early detection and prompt surgical treatment. It has been demonstrated that the major diagnostic and prognostic parameters of melanoma are the vertical thickness, three-dimensional (3D) size and shape, and color of the lesion.
  • R Singal, R R Belliveau
    Quantitation of megakaryocytes in normal bone marrow
    1988 Feb;10(1):33-6.
    Abstract: A quantitation of megakaryocytes in normal bone marrow biopsies was performed using a simple direct method of counting. In bone marrow biopsies having a mean cellularity of 72% (range of 60% to 85%), the mean number of megakaryocytes per high-power field (450 X) was 1.5 (range of 0.4 to 2.7).
  • P H Bartels, J E Weber, L Duckstein
    Machine learning in quantitative histopathology
    1988 Aug;10(4):299-306.
    Abstract: The role of expert systems functioning as process controllers in learning image understanding systems is discussed. Numeric learning systems already have found a number of applications in cytologic and histopathologic diagnosis.
  • Z Darzynkiewicz
    Flow cytometry in cytopathology. Overview and perspectives
    Review: 1988 Dec;10(6):459-61.
    Abstract: The future applications of flow cytometry (FCM) are briefly discussed. Whereas the early goals of its clinical applications were cancer diagnosis and classification, it has now become apparent that FCM can more successfully provide information on a variety of cell constituents of crucial importance in the evaluation of tumor prognosis and treatment sensitivity.
  • H Guski, P Hufnagl, A Freitag, K Wenzelides, K Voss, H Simon
    Automated histometry in fibrocystic breast disease
    1988 Apr;10(2):101-6.
    Abstract: Ductal epithelial proliferations of the mammary gland in biopsy material from 101 patients, including 52 with proliferative fibrocystic disease (mastopathy), were quantitatively analyzed by means of the Robotron A 6471 system together with AMBA/R software.
  • Z Darzynkiewicz, F Traganos
    Unstainable DNA in cell nuclei. Comparison of ten different fluorochromes
    Comparative Study: 1988 Dec;10(6):462-6.
    Abstract: Ten fluorochromes with specificity for DNA were used to compare the stainability of nuclei of exponentially growing, nondifferentiated Friend leukemia (FL) cells with that of dimethylsulfoxide-induced, fully differentiated FL cell nuclei.
  • J P Baak, P H Kurver
    Development and use of a rule-based pathology expert consultation system
    1988 Jun;10(3):214-8.
    Abstract: Since histologic sections of pathologically changed tissues (e.g., tumors and inflammations) are highly complex structures, their subjective diagnostic or prognostic interpretation may result in a lack of interobserver and intraobserver agreement.
  • C Savy, S Margules, A Solari, P Saint-Jean, E Farkas-Bargeton
    An image analysis morphometric method for the study of myelinated nerve fibers from mouse trigeminal root
    1988 Oct;10(5):307-16.
    Abstract: For the morphometric light microscopic study of myelinated fibers in mouse trigeminal root, it was necessary to write: (1) an entirely automatic analysis program for the myelinated axons inside the myelin sheath, based on the detection of the myelin sheaths, and (2) an interactive analysis program for the myelinated fibers outside the myelin sheath, due to the high density of compactness of the myelinated fibers based on an indirect fiber individualization by reconstructing them from their axons.
  • C Cibert, A Skalli, D Schoëvaërt
    Statistical analysis of morphometrically analyzed outlines of cells in culture. Comparison of populations of normal and polyomavirus-transformed FR 3T3 fibroblasts
    Comparative Study: 1988 Oct;10(5):329-38.
    Abstract: The correspondence analysis method was used to statistically characterize the morphologies of populations of normal (nontransformed; N.3T3) and polyomavirus-transformed (Py.3T3) Fisher rat 3T3 fibroblasts in culture, based on morphologic parameters calculated according to a previously described morphometric method.
  • M F Chretien, A Chassevent, K Malkani, A Rebel
    Flow cytometric DNA analysis in the diagnosis of lung tumors. A comparison with conventional methods
    Comparative Study: 1988 Aug;10(4):251-5.
    Abstract: The efficiency of flow cytometric (FCM) DNA analysis in the diagnosis of lung carcinoma was compared with that of conventional cytologic techniques on bronchial brushing and fine needle aspiration samples from 461 patients.
  • I T Young
    Sampling density and quantitative microscopy
    1988 Aug;10(4):269-75.
    Abstract: The sampling densities required for the quantitative analysis of digitized microscope images is discussed.
  • S W Jordan, J M Brayer, P H Bartels, R E Anderson
    Video-based image collection for quantitative histopathology
    1988 Feb;10(1):37-46.
    Abstract: Obtaining histologic images for computer-based morphometric analysis is associated with a number of standardization problems, which must be solved if reproducible data collection is expected.
  • C A Rubio, A Porwit
    Quantitation of fibrosis in liver biopsies
    1988 Apr;10(2):107-9.
    Abstract: After 15 years of subjectively estimating the degree of fibrosis in liver biopsies stained with Sirius red F3BA, the amounts of Sirius red-stained fibrotic areas were quantitated with the help of a Cortex IQ 130 image quantifier.
  • J E Weber, P H Bartels, W Griswold, W Kuhn, S H Paplanus, A R Graham
    Colonic lesion expert system. Performance evaluation
    1988 Apr;10(2):150-9.
    Abstract: A computer-based expert system for diagnosing colonic sections as normal, adenoma or adenocarcinoma is described, along with an evaluation of its performance.
  • J Thiele, R Zankovich, G Schneider, B Kremer, R Fischer, V Diehl
    Primary (essential) thrombocythemia versus polycythemia vera rubra. A histomorphometric analysis of bone marrow features in trephine biopsies
    Comparative Study: 1988 Oct;10(5):375-82.
    Abstract: A morphometric analysis of bone marrow biopsies was performed in 25 patients each with clinical diagnoses of primary (essential) thrombocythemia (PTH) and polycythemia vera rubra (P. vera) according to the rigid diagnostic criteria of the Polycythemia Vera Study Group to reveal significant differences in the histomorphologic features between these disorders.
  • L Matturri, D Bauer
    Morphometric characteristics of hepatocellular dysplasia
    1988 Oct;10(5):339-42.
    Abstract: Morphometric study of liver biopsies from six entities (normal tissue, post-hepatitis cirrhosis, post-alcoholic cirrhosis, cancer-related cirrhosis, hepatocellular adenoma and hepatocellular adenocarcinoma) confirmed that this technique can be a valuable adjunct to histopathologic study in the examination of such specimens.
  • C A Rubio, A Uribe, A Svensson, I May
    A method for the quantitation of intestinal metaplasia of the stomach by morphometry
    1988 Apr;10(2):115-9.
    Abstract: A novel method to quantitate the extent of intestinal metaplasia in gastrectomy specimens is presented.
  • P Tosi, L Leoncini, J P Baak, P Luzi, M Cintorino, P Barbini
    Comparative morphometric analysis of nuclear area and shape in peripheral T-zone lymphomas and in paracortical areas of normal and reactive lymph nodes
    1988 Aug;10(4):285-93.
    Abstract: The areas and shapes of cell nuclei were morphometrically analyzed in peripheral T-zone lymphomas, which have a characteristic nuclear pleomorphism, as well as in paracortical areas of normal and reactive lymph nodes; the aim of the study was to compare the neoplastic and nonneoplastic lymphoid cell populations.
  • C A Rubio, G U Auer, Y Kato, F S Liu
    DNA profiles in dysplasia and carcinoma of the human esophagus
    1988 Jun;10(3):207-10.
    Abstract: The nuclear DNA content was microspectrophotometrically measured in 16 resected esophagi having dysplasia, carcinoma in situ and/or early invasive squamous carcinoma.