Volume 28 (2012) Issue 1 - Issue 6
- Mohamed Ali Bedaiwy, Javier Noriega, Mahmoud Abdel Aleem, Sajal Gupta, Ahmed M AbulHassan, Jennifer Brainard, Alaa M Ismail, Tommaso Falcone
Evaluation of peritoneal fluid hemosiderin-laden macrophages in biopsy-proven endometriosis
2012 Feb;34(1):23-7
Abstract: To evaluate peritoneal fluid hemosiderin-laden macrophages (H-LMs) in patients with endometriosis compared to controls. - Alessandra Filosa, Andrea Fabiani
From biopsy to active surveillance in small renal masses: is it feasible?
2012 Apr;34(2):109-10 - Shelly Sharma, Pranab Dey, Uma Nahar Saikia, Raje Nijhawan
Micronucleus scoring in urine cytology specimen by DNA-specific stain
2012 Feb;34(1):56-60
Abstract: To evaluate the role of micronuclei (MN) scoring in urinary cytology of bladder transitional cell carcinoma (TCC). - Priya Thomas, Pratibha Ramani, Priya Premkumar, Anuja Natesan, Herald J Sherlin, Thiruvengadam Chandrasekar
Micronuclei and other nuclear anomalies in buccal mucosa following exposure to X-ray radiation
2012 Jun;34(3):161-9
Abstract: To evaluate DNA damage and cellular death in exfoliated buccal mucosa cells from healthy individuals following dental X-ray exposure, to compare effects of different types of radiographic techniques using the buccal cytome assay and to standardize the staining procedure. - Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi
Classification and grading of noninvasive and invasive neoplasms of the urothelium
Review: 2012 Jun;34(3):111-9
Abstract: The classification and grading of the noninvasive, intraepithelial neoplasms of the urothelium are based on the morphological pattern of growth, i.e., papillary and flat (and endophytic), and on their degree of architectural and cytologic abnormalities. - Maristella Bianconi, Mario Scartozzi, Luca Faloppi, Alessandro Bittoni, Elena Maccaroni, Riccardo Giampieri, Michela Del Prete, Luciano Burattini, Stefano Cascinu
Angiogenetic pathway as a therapeutic target in renal cell carcinoma
Review: 2012 Feb;34(1):15-22
Abstract: For several decades, metastatic renal cell carcinoma (mRCC) was considered resistant to therapy and thus linked to poor prognosis. - Gilbert Bigras
Color deconvolution. Optimizing handling of 3D unitary optical density vectors with polar coordinates
2012 Jun;34(3):149-60
Abstract: Color deconvolution relies on determination of unitary optical density vectors (OD(3D)) derived from pure constituent stains initially defined as intensity vectors in RGB space. OD(3D) can be defined in polar coordinates (phi, theta, radius); always being equal to one, radius can be ignored. Easier handling of unitary optical density 2D vectors (OD(2D)) is shown. - Peter H Bartels, Hubert G Bartels, David S Alberts, Michael Yozwiak, Anil R Prasad, Evan S Glazer, Robert S Krouse
Karyometry of nuclear phenotypes in cutaneous squamous cell cancer
2012 Feb;34(1):1-8
Abstract: To establish the karyometric characteristics of the two main nuclear phenotypes in cutaneous squamous cell cancer (cSCC) lesions. - Mehrnoush Khojasteh, Timon P H Buys, Jean LeRiche, Stephen Lam, Martial Guillaud, Calum MacAulay
A framework for quantitative assessment of Ki67 distribution in preneoplastic bronchial epithelial lesions
2012 Jun;34(3):120-38
Abstract: Deregulated cell proliferation is a hallmark of cancer, and Ki67 immunostaining can be used to identify proliferating cells. Evaluation of cell proliferation may have utility as a biomarker of epithelial malignant transformation risk. To date, most analyses of Ki67 staining have been restricted to semiquantitative estimations of the degree of staining or the measurement of the fraction of Ki67-positive cells within the epithelium. We sought to develop a robust, objective means of quantitatively evaluating Ki67 immunostaining for lung precancerous lesions. - Roberta Mazzucchelli, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Rodolfo Montironi
Spectrum of prostatic nonepithelial tumors and tumorlike conditions with spindle cell features
2012 Jun;34(3):139-44
Abstract: There exists a wide and heterogeneous spectrum of spindle cell lesions that can originate from the prostatic stroma. This includes benign and malignant neoplasms as well as tumorlike conditions. Their diagnosis in small biopsy specimens is often difficult because of the potential for sampling error. - Yeong-Hui Kim, Ga-Eon Kim, Ji Shin Lee, Jae Hyuk Lee, Jong Hee Nam, Chan Choi, Min Ho Park, Jung Han Yoon
Hormone receptors expression in phyllodes tumors of the breast
2012 Feb;34(1):41-8
Abstract: To ascertain the hormonal receptor profiles of the epithelial and stromal components of phyllodes tumors (PTs) and determine their relationship with stromal proliferation. - Jorge Ernesto González, Manual Lee, Joan Francesc Barquinero, Marco Valente, Sandrine Roch-Lefèvre, Omar García
Quantitative image analysis of gamma-H2AX foci induced by ionizing radiation applying open-source programs
2012 Apr;34(2):66-71
Abstract: To test a CellProfiler pipeline for automated counting and characterization of gamma-H2AX foci in color images of human cultured cells. - Antonio Lopez-Beltran, Liang Cheng, Ana Blanca, Rodolfo Montironi
Cell proliferation and apoptosis in prostate needle biopsies with adenocarcinoma Gleason score 6 or 7
2012 Apr;34(2):61-5
Abstract: To analyze whether cell proliferation and apoptotic indexes in needle biopsies with prostate cancer Gleason 6 or 7 can identify more objectively Gleason score 6 or 7 in needle biopsy samples. - Adarsh Barwad, Pranab Dey
Multifractal spectrum differentiation of well-differentiated adenocarcinoma from complex atypical hyperplasia of the uterus
2012 Apr;34(2):105-8
Abstract: To introduce a new field of multifractal spectrum in distinguishing between endometrial well-differentiated adenocarcinoma (WDAC) and complex atypical hyperplasia (CAH). - Ayhan Ozcan, Bulent Kurt, Yildirim Karslioglu, Ali Hakan Cermik, Alp Bilal Firat
Nuclear morphometry in the differential diagnosis of eosinophilic renal epithelial tumors
2012 Jun;34(3):145-8
Abstract: To assess the potential contribution of nuclear morphometry to the differential diagnosis of renal epithelial tumors with eosinophilic cytoplasm, including chromophobe renal cell carcinoma (ChRCC), the eosinophilic variant of clear cell renal cell carcinoma (EoRCC), and oncocytoma. - Pablo Conesa-Zamora, Javier Trujillo-Santos, Francisco Javier Orantes-Casado, Sebastián Ortiz-Reina, Daniel Torres-Moreno, Miguel Pérez-Guillermo
Analysis of performance characteristics of five cell cycle-related immunohistochemical markers and human papillomavirus genotyping in the diagnosis of cervical squamous cell carcinoma precursor lesions
2012 Feb;34(1):49-55
Abstract: To study the performance values of a set of five immunohistochemical markers involved in cell cycle regulation as a potential aid in the differential diagnosis between squamous intraepithelial lesions (SILs) and normal or benign conditions of the uterine cervix. - Lidiana Ubiña Oliveira, Celina Faig Lima, Miguel Angelo Castillo Salgado, Ivan Balducci, Janete Dias Almeida
Comparative study of oral mucosa micronuclei in smokers and alcoholic smokers
Comparative Study: 2012 Feb;34(1):9-14
Abstract: To compare the frequency of micronuclei and metanucleated anomalies in the oral mucosa of smokers, alcoholic smokers, and nonsmokers. - Enrico Bollito, Stefano De Luca, Matteo Cicilano, Roberto Passera, Susanna Grande, Carmen Maccagnano, Susanna Cappia, Angela Milillo, Francesco Montorsi, Roberto Mario Scarpa, Mauro Papotti, Donato Franco Randone
Prostate cancer gene 3 urine assay cutoff in diagnosis of prostate cancer: a validation study on an Italian patient population undergoing first and repeat biopsy
Multicenter Study: 2012 Apr;34(2):96-104
Abstract: To determine an optimal prostate cancer gene 3 (PCA3) cutoff in predicting prostate cancer in Italian patients undergoing first or repeat biopsy. - Ian S Hagemann, Theresa L Pasha, Shelley A Roberts, Sabrina W Yum, Paul J Zhang
Aberrant connexin 43 and 26 expression in cervical dysplasia
2012 Feb;34(1):28-40
Abstract: To determine whether connexin (Cx) expression is altered in cervical dysplasia. - Rossana Berardi, Alfredo Santinelli, Azzurra Onofri, Alessandro Brunelli, Chiara Pierantoni, Eleonora Pisa, Alessandra Pagliacci, Daniela Stramazzotti, Lina Zuccatosta, Paola Mazzanti, Armando Sabbatini, Stefano Gasparini, Italo Bearzi, Stefano Cascinu
Maspin expression is a favorable prognostic factor in non-small cell lung cancer
2012 Apr;34(2):72-8
Abstract: To evaluate prognostic impact of maspin expression in patients with resected non-small cell lung cancer (NSCLC). - Asmaa Gaber Abdou, Shawky El Farargy, Iman Seleit, Azaa Gaber Antar, Mohammed Elhefny, Nada Farag Elnaidany
Osteopontin expression in chronic plaque psoriasis: an association with the severity of disease
2012 Apr;34(2):79-85
Abstract: To explore the possible role of osteopontin (OPN) in chronic plaque psoriasis and understand the role of inflammation in psoriasis. - Vladimir Kirillov, Olga Emeliyanova
Differential diagnosis of follicular tumor by expert systems based on a set of quantitative features of thyrocyte nuclei and aggregates
2012 Apr;34(2):86-95
Abstract: To develop expert systems for classification of follicular thyroid tumor at a preoperative stage.