Volume 27 (2011) Issue 1 - Issue 6
- Joseph Soltzberg, Sarah Frischmann, Christiaan van Heeckeren, Nicole Brown, Arnold Caplan, Tracey L Bonfield
Quantitative microscopy in murine models of lung inflammation
2011 Oct;33(5):245-52
Abstract: To develop a quantitative means to measure lung inflammation using the murine models of chronic asthma and cystic fibrosis (CF). - María Teresa González Serrano, María José Ríos Moreno, Manuel de Miguel Rodríguez, Fernando Casco, Hugo Galera-Ruiz, María Teresa Vargas de los Monteros, Inmaculada Trigo Sánchez, Ricardo González-Cámpora, Hugo Galera-Davidson
Molecular findings of nasopharyngeal carcinoma in a European population
2011 Dec;33(6):316-22
Abstract: To explore biomolecular characteristics of a group of patients with nasopharyngeal carcinoma from European (Spanish) hospitals, addressing the pathogenesis of the tumor and the response to treatment. - Ricardo González-Cámpora, Mario Díaz Delgado, Alicia Hernández Amate, Sofía Pereira Gallardo, María Sánchez León, Antonio López Beltrán
Old and new immunohistochemical markers for the diagnosis of gastrointestinal stromal tumors
2011 Feb;33(1):1-11
Abstract: Gastrointestinal stromal tumors (GISTs) are generally CD117-positive and KIT or PDGFRA mutation-driven mesenchymal tumors of the gastrointestinal tract, probably originating in interstitial cells of Cajal or related precursors. - Ana Carolina Amorim Pellicioli, Fernanda Visioli, Luciana Adolfo Ferreira, Chris Krebs Danilevicz, Vinicius Coelho Carrard, Pantelis Varvaki Rados
Cytogenetic abnormalities in exfoliated oral mucosal cells and their association with oral cancer
2011 Oct;33(5):271-6
Abstract: To assess cytogenetic abnormalities through quantification of micronuclei, broken eggs, and karyorrhexis, in cells from normal oral mucosa of individuals exposed to carcinogens (alcohol and tobacco) and adjacent to leukoplakias and squamous cell carcinomas. - Gionata De Vico, Marielda Cataldi, Paola Maiolino, Francesca Carella, Stefano Beltraminelli, Gabriele A Losa
Fractal pattern of canine trichoblastoma
2011 Jun;33(3):151-7
Abstract: To assess by fractal analysis the specific architecture, growth pattern, and tissue distribution that characterize subtypes of canine trichoblastoma, a benign tumor derived from or reduplicating the primitive hair germ of embryonic follicular development. - Marco Wiltgen, Marcus Bloice, Silvia Koller, Rainer Hoffmann-Wellenhof, Josef Smolle, Armin Gerger
Computer-aided diagnosis of melanocytic skin tumors by use of confocal laser scanning microscopy images
2011 Apr;33(2):85-100
Abstract: To check the applicability of machine learning algorithms for the computer-aided diagnosis of confocal laser scanning microscopy (CLSM) views of skin lesions. - Alexandra Varlatzidou, Abraham Pouliakis, Magdalini Stamataki, Christos Meristoudis, Niki Margari, George Peros, John G Panayiotides, Petros Karakitsos
Cascaded learning vector quantizer neural networks for the discrimination of thyroid lesions
2011 Dec;33(6):323-34
Abstract: To investigate capability of combination of learning vector quantizer (LVQ) neural networks (NNs) in discrimination of benign from malignant thyroid lesions. - Adam Szpechcinski, Piotr Kopinski, Dorota Giedronowicz, Adriana Rozy, Paulina Jagus, Malgorzata Szolkowska, Joanna Chorostowska-Wynimko
Simple flow cytometric protocol of CD4+/CD8+ lymphocyte ratio assessment in bronchoalveolar lavage fluids from patients with interstitial lung diseases
Clinical Trial: 2011 Oct;33(5):289-96
Abstract: To validate the fast and accurate flow cytometric (FCM) protocol using blood-standardized antibodies for alveolar lymphocyte subtyping with respect to standard immunocytochemistry (IC). - Soraia de Carvalho, Adriana Bittencourt Campaner, Sônia Maria Rolim Rosa Lima, Maria Antonieta Longo Galvão Silva, Paulo Augusto Ayroza Ribeiro
Differential expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women
2011 Apr;33(2):61-7
Abstract: To evaluate the immunoexpression of estrogen receptor (ER) and progesterone receptor (PR) in gland and stromal cells of endometrial polyps in postmenopausal women. - Pauline Po Yee Lui, Grace Ho, Yuk Wa Lee, Po Yan Ho, Wing Nin Lo, Chun Kwong Lo
Validation of a histologic scoring system for the examination of quality of tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction
2011 Feb;33(1):36-49
Abstract: To develop and validate a histologic scoring system for the assessment of tendon graft to bone tunnel healing in anterior cruciate ligament (ACL) reconstruction. - Laura Conde, Susana Moyano, Isabel Vilaseca, Miguel Moragas, Antonio Cardesa, Alfons Nadal
Role of microsatellite instability in young patients with laryngeal carcinoma
2011 Apr;33(2):111-8
Abstract: To determine whether early development of carcinoma in young patients could be explained by an alternative pathway such as microsatellite instability or whether it follows the classical tumor suppressor pathway characterized by loss of heterozygosity. - Aris Spathis, Christine Kottaridi, John Georgoulakis, Periklis Foukas, Ioannis Panayiotides, George Peros, Petros Karakitsos
Cell cycle analysis of colorectal brushings collected in liquid-based cytology
2011 Feb;33(1):29-35
Abstract: To evaluate the possibility of robust cell cycle analysis from liquid-based cytology samples. - Shawna Noy, Euvgeni Vlodavsky, Geula Klorin, Karen Drumea, Ofer Ben Izhak, Eli Shor, Edmond Sabo
Computerized morphometry as an aid in distinguishing recurrent versus nonrecurrent meningiomas
2011 Jun;33(3):141-50
Abstract: To use novel digital and morphometric methods to identify variables able to better predict the recurrence of intracranial meningiomas. - Petros Karakitsos, Abraham Pouliakis, Christos Meristoudis, Niki Margari, Dimitrios Kassanos, Maria Kyrgiou, John G Panayiotides, Evangelos Paraskevaidis
A preliminary study of the potential of tree classifiers in triage of high-grade squamous intraepithelial lesions
2011 Jun;33(3):132-40
Abstract: To investigate the potential value of tree classifiers for the triage of high-grade squamous intraepithelial lesions. - Francesc Alameda, Lara Pijuan, Belen Lloveras, Imma Soler, Emilia Romero, Ramon Carreras, Sergio Serrano
Automated screening of gynecologic cytology: a comparison of results
Comparative Study: 2011 Feb;33(1):25-8
Abstract: To compare the results among conventional gynecologic cytology liquid-based cytology and manual screening and liquid-based cytology automatically screened. - Prashant Sharma, Hara Prasad Pati, Pravas Chandra Mishra, Amit Kumar Dinda, Ruchika Gupta, Alok Sharma, Tony George Jacob
Inability of immunomorphometric assessment of angiogenesis to distinguish primary versus secondary myelofibrosis
2011 Aug;33(4):236-44
Abstract: To explore the utility of bone marrow (BM) angiogenesis in differentiating primary myelofibrosis (PMF) from secondary myelofibrosis (MF). - Sandeep Kumar Arora, Pranab Dey
Fractal and lacunar dimension of the chorionic villi of molar pregnancy
2011 Apr;33(2):82-4
Abstract: To explore the role of fractal geometry to differentiate molar pregnancies from normal chorionic villi. - Nandan Kumar Mondal, Debangshu Das, Bidisha Mukherjee, Manas Ranjan Ray
Upregulation of AgNOR expression in epithelial cells and neutrophils in the airways and leukocytes in peripheral blood of women chronically exposed to biomass smoke
2011 Feb;33(1):50-9
Abstract: To evaluate the impact of indoor air pollution from biomass fuel use on ribosome biogenesis in airway cells and peripheral blood leukocytes using the argyrophilic nucleolar organizer region (AgNOR) staining technique. - Arzu Avci, Omer Günhan, Yildirim Karslioğlu, Bulent Celasun
Nasopharyngeal nonkeratinizing (undifferentiated) monstrous cell carcinoma. A case report
Case Reports: 2011 Oct;33(5):297-302
Abstract: The histologic type of nasopharyngeal carcinoma can be an important factor in the prognosis. The effects, if any, of the degree of cellular pleomorphism is uncertain. - Jochen Möckel, Jens Quaas, Helga Meisel, Anne-Sophie Endres, Volker Schneider
Human papillomavirus E6/E7 mRNA testing has higher specificity than liquid-based DNA testing in the evaluation of cervical intraepithelial neoplasia
2011 Dec;33(6):311-5
Abstract: To examine the specificity of human papillomavirus (HPV) E6/E7 mRNA testing for intraepithelial precursor lesions and invasive carcinoma of the uterine cervix in 358 women and compare the results with those of the most widely used DNA technique. - Mélanie Fafin-Lefevre, Fabrice Morlais, Lydia Guittet, Bénédicte Clin, Guy Launoy, Françoise Galateau-Sallé, Benoît Plancoulaine, Paulette Herlin, Marc Letourneux
Nuclear morphology for the detection of alterations in bronchial cells from lung cancer: an attempt to improve sensitivity and specificity
2011 Aug;33(4):183-95
Abstract: To identify which morphologic or densitometric parameters are modified in cell nuclei from bronchopulmonary cancer based on 18 parameters involving shape, intensity, chromatin, texture, and DNA content and develop a bronchopulmonary cancer screening method relying on analysis of sputum sample cell nuclei. - Sergio Tripodi, Bruno Jim Rocca, Maria Raffaella Ambrosio, Filippo Gentile, Marcella Cintorino
Pelvic urothelial carcinoma with nested pattern of growth and an uncommon clinical presentation: a case report
Case Reports: 2011 Dec;33(6):340-4
Abstract: Nested variant of urothelial carcinoma (NVUC) is a rare and often unrecognized urothelial neoplasia. Diagnosis is based on morphology only, and no immunohistochemical or cytogenetic differences from usual high-grade urothelial carcinomas have been reported. - Farveen Marican Abu Backer, Nik Raihan Nik Mustapha, Nor Hayati Othman
Combined expression of p161NK4a and p27Kip1, but not p21WAF1, differentiates endocervical from endometrial adenocarcinoma
2011 Oct;33(5):283-8
Abstract: To differentiate endocervical adenocarcinoma (ECA) from endometrial adenocarcinoma (EMA) using p16INK4a, p21WAF1 and p27Kip1. - Isidro Machado, Amparo Ruiz-Sauri, José A López-Guerrero, Antonio Llombart-Bosch
Morphometric analysis of DNA ploidy and nuclear cell cycle regulators in Ewing's sarcoma/primitive neuroectodermal tumor
2011 Apr;33(2):101-10
Abstract: To study the morphometry of DNA ploidy as a prognostic factor, compare qualitative and quantitative methods using immunohistochemical markers, and evaluate the utility of morphometry in the differential diagnosis of Ewing's sarcoma family of tumor (ESFT) subtypes and small round cell tumors (SRCTs) of bone. - Celina Faig Lima, Sabrina Ferreira Pinotti Leite, Yasmin Rodarte Carvalho, Luiz Antonio Guimarães Cabral, Ivan Balducci, Janete Dias Almeida
Cytokeratin profile in exfoliative cytology of smokers
2011 Feb;33(1):19-24
Abstract: To compare the expression of cytokeratins (CKs) 6, 16, 19 and pan-cytokeratin (PAN) in oral mucosa cells between smokers and nonsmokers to determine the proliferative activity and expression indicative of a potential for malignant transformation. - Alessandra Filosa, Andrea Fabiani
Epigenetic therapy in cancer: perspective and paradoxes
2011 Oct;33(5):303-4 - Christine Kottaridi, Sotirios Tsiodras, Aris Spathis, Aikaterini Chranioti, Asimakis Pappas, Dimitrios Kassanos, Ioannis Panayiotides, Petros Karakitsos
Clinical performance of human papillomavirus E6, E7 mRNA flow cytometric assay compared to human papillomavirus DNA typing
Comparative Study: 2011 Dec;33(6):305-10
Abstract: To use flow cytometry to screen cervical samples for the overexpression of human papillomavirus (HPV) E6 and E7 mRNA and compare the performance of this assay with an HPV DNA array for the detection of high-grade cervical lesions. - Kiyotada Washiya, Tatsusuke Sato, Tomisato Miura, Kiyosi Tone, Keiko Kojima, Jun Watanabe, Hiroshi Kijima
Cytologic difference between benignity and malignancy in suspicious cases employing urine cytodiagnosis using a liquid-based method
2011 Jun;33(3):169-74
Abstract: To follow cases with atypical cells or suspicious cases on first examination by liquid-based cytology (LBC), comparing cases that became negative and those confirmed to be positive (urothelial carcinoma) with regard to the cell morphology. - Rosalia Ricco, Teresa Lettini, Nicola Arpaia, Tiziana Valente, Giuseppe Ingravallo, Maria Lucia Vurro, Raffaella De Pascalis, Vittorio Pesce Delfino
Analytical and dimensional morphometry in early diagnosis cutaneous melanoma with dermoscopic images
2011 Aug;33(4):229-35
Abstract: To give to the clinician an objective numerical assessment tool to evaluate melanomas so that a diagnosis can be reached with the assistance of computerized procedures. - Björn L Isfoss, Bernard Majak, Christer Busch, Geir J Braathen
Diagnosis of intraurothelial neoplasia. Interobserver variation and the value of individual histopathologic attributes
2011 Apr;33(2):75-81
Abstract: To determine interobserver variation in histopathologic diagnosis of carcinoma in situ (CIS) and dysplasia (collectively intraurothelial neoplasia [IUN]) of the bladder and identify histomorphologic features important for diagnosis. - André Huisman, Lennert S Ploeger, Hub F J Dullens, Trudy N Jonges, Paul J van Diest
Discrimination between benign and malignant prostate biopsies using three-dimensional chromatin texture analysis by confocal laser scanning microscopy
2011 Oct;33(5):265-70
Abstract: To evaluate the clinical usefulness of computing three-dimensional (3-D) nuclear texture features on prostate biopsy specimens to discriminate among benign, prostatic intraepithelial neoplasia (PIN), and malignant specimens. - Elva I Cortés-Gutiérrez, Martha I Dávila-Rodríguez, José Luís Fernandez, Carmen López-Fernández, Jaime Gosálvez
DNA damage in women with cervical neoplasia evaluated by DNA breakage detection-fluorescence in situ hybridization
2011 Jun;33(3):175-81
Abstract: To evaluate the association between the progressive stages of cervical dysplasia and DNA damage. - Alessandra Filosa, Andrea Fabiani
Penile cancer: different histopathologic types with a critical clinical approach
2011 Apr;33(2):119-20 - Rossana Berardi, Alfredo Santinelli, Alessandro Brunelli, Azzurra Onofri, Chiara Pierantoni, Mario Scartozzi, Eleonora Pisa, Daniela Stramazzotti, Paola Mazzanti, Lina Zuccatosta, Stefano Gasparini, Armando Sabbatini, Stefano Cascinu
Epidermal growth factor receptor status in stages of resected non-small cell lung cancer: implications for treatment with epidermal growth factor receptor inhibitors
2011 Aug;33(4):196-204
Abstract: To verify whether epidermal growth factor receptor (EGFR) status could be considered a prognostic factor and assessment of it an effective tool for planning therapy in patients with non-small cell lung cancer (NSCLC). - Ilambarthi Lokamani, Mee-Lee Looi, Siti Aishah Md Ali, Ahmad Zailani Hatta Mohd Dali, Rahman Jamal
Clusterin as a potential marker in distinguishing cervical neoplasia
2011 Aug;33(4):223-8
Abstract: To assess the immunoexpression of clusterin (CLU) in the progression of cervical neoplasia. - Emmanouil A Zoulias, Pantelis A Asvestas, George K Matsopoulos, Sofia Tseleni-Balafouta
A decision support system for assisting fine needle aspiration diagnosis of thyroid malignancy
2011 Aug;33(4):215-22
Abstract: To assist diagnosis of thyroid malignancy, implementing a decision support system (DSS) using fine needle aspiration biopsy (FNAB) data. - Björn L Isfoss, Bernard Majak, Christer Busch, Geir J Braathen
Simplification of grading papillary urothelial neoplasia using a reduced set of diagnostic features
2011 Apr;33(2):68-74
Abstract: To determine whether a reduced set of the histopathologic features used in internationally accepted classifications is capable of accurately grading papillary urothelial neoplasms (PUN). - Pranab Dey, Amit Lamba, Savita Kumari, Neelam Marwaha
Application of an artificial neural network in the prognosis of chronic myeloid leukemia
2011 Dec;33(6):335-9
Abstract: To use a commercially available artificial neural network (ANN) software program to distinguish prognostically good and bad cases of chronic myeloid leukemia (CML). - Pranab Dey
Multifractal spectrum of chorionic villi: a novel approach
2011 Aug;33(4):211-4
Abstract: To measure the multifractal dimension in histopathology sections of chorionic villi to study its role to distinguish between normal chorionic villi and hydatidiform mole. - Michael W Kilpatrick, Christine E Sheehan, William A Marganski, Triantafyllos Tafas, Merrill S Ross, Jeffrey S Ross
Determination of HER2 gene status by fully automated fluorescence microscopy
2011 Aug;33(4):205-10
Abstract: To examine fluorescence in situ hybridization (FISH) in HER2 amplification in response rates to trastuzumab therapy and both taxane and anthracycline-based chemotherapy regimens. - Kiran Kumar, M Ram Manohar
Consistency of histomorphometric measurements of normal oral epithelium subjected to variations in routine tissue processing
2011 Feb;33(1):12-8
Abstract: To determine the effect of formalin fixation time on histomorphometry by changing the fixation time and the effect of the age of processing solutions on histomorphometry by processing tissues in solutions of varying ages. - Muthu Rama Krishnan Mookiah, Pratik Shah, Chandan Chakraborty, Ajoy K Ray
Brownian motion curve-based textural classification and its application in cancer diagnosis
2011 Jun;33(3):158-68
Abstract: To develop an automated diagnostic methodology based on textural features of the oral mucosal epithelium to discriminate normal and oral submucous fibrosis (OSF). - Christian Garbar, Corinne Mascaux
Expression of MUC1 (Ma695) in noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification of the noninvasive urothelial neoplasm. An immunologic tool for the pathologist?
2011 Oct;33(5):277-82
Abstract: To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification. - Vladimir Kirillov, Olga Emeliyanova
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia
2011 Oct;33(5):253-64
Abstract: To determine the efficiency of the developed expert system based on a set of qualitative signs of cell atypia and their weighting coefficients in the differential diagnosis of follicular cancer and follicular adenoma of the thyroid gland. - Hai-Shan Wu, Feng-Qiang Wang, Yoel Smicun, David Fishman
Recognition of linear stress fibers based on Hough transform
2011 Jun;33(3):121-31
Abstract: To present an algorithm based on Hough transform for recognition and extraction of linear stress fibers formed on exposure to lysophosphatidic acid (LPA).
