Volume 26 (2010) Issue 1 - Issue 6
- Yia Swam Tan, Lay Guat Ng, Sidney Kam-Hung Yip, Miah-Hiang Tay, Alvin Soon-Tiong Lim, Sim Leng Tien, Liang Cheng, Puay Hoon Tan
Synovial sarcoma of the kidney: a report of 4 cases with pathologic appraisal and differential diagnostic review
Review: 2010 Aug;32(4):239-45
Abstract: Synovial sarcoma of the kidney is rare. It is clinicoradiologically indistinguishable from the more frequently encountered renal cell carcinoma. Histologically it needs to be differentiated from other spindle cell lesions occurring within the kidney, including a spectrum of benign to malignant tumors. - Andrea Benedetto Galosi
Clinical and experimental applications of botulinum toxins in humans: the prostate gland as example
Editorial: 2010 Aug;32(4):183-5 - Roberta Mazzucchelli, Rodolfo Montironi, Doriana Morichetti, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng
Comparison between incidentally and clinically detected prostate cancer: implications for prostate cancer screening programs and focal therapy
Review: 2010 Jun;32(3):151-4
Abstract: Incidental prostate cancer is frequently observed in radical cystoprostatectomy. The majority are considered clinically insignificant. The relationship between clinically and incidentally detected cancer is uncertain. - Lorenzo Lo Muzio, Angela Santoro, Tiziana Pieramici, Pantaleo Bufo, Luca Di Alberti, Piergiorgio Mazzotta, Alessandro Mazzotta, Francesco Carinci, Corrado Rubini, Lucio Lo Russo
Immunohistochemical expression of CD3, CD20, CD45, CD68 and bcl-2 in oral squamous cell carcinoma
2010 Apr;32(2):70-7
Abstract: To study the main processes involved in oral squamous cell carcinoma (OSCC): apoptosis and inflammation. - Michael J Ray, Swaroop S Singh, Warren Davis, William E McCann, James L Mohler, James R Marshall
Variability in visual segmentation of digitized prostate tissue microarray cores
2010 Dec;32(6):301-10
Abstract: To examine bias associated with human-interactive semi-automated systems key components with machine vision used in quantitative histometry. - Eva Galizia, Gessica Giorgetti, Gina Piccinini, Alfredo Santinelli, Cristian Loretelli, Francesca Bianchi, Daniela Gagliardini, Giovanna Carbonari, Eleonora Pisa, Laura Belvederesi, Raffaella Bracci, Concetta Ferretti, Fabio Corradini, Riccardo Cellerino
BRCA1 expression in triple negative sporadic breast cancers
2010 Feb;32(1):24-9
Abstract: To study how to identify patients with "triple negative" sporadic breast cancers (BCs) having BRCA1 silenced or down-regulated due to epigenetic BRCA1 inactivation. - Gabriel Landini, David A Randell, Toby P Breckon, Ji Wan Han
Morphologic characterization of cell neighborhoods in neoplastic and preneoplastic epithelium
2010 Feb;32(1):30-8
Abstract: To explore tissue organization based on the geometry of cell neighborhoods in histologic preparations. - Teresa Pusiol, Maria Grazia Zorzi, Irene Piscioli
Coexistence of bladder prostatic-type polyp and urothelial papilloma
2010 Oct;32(5):299-300 - Marta Orsenigo, Silvia Brich, Carla Riva, Elena Conca, Rossella Bertulli, Palma Dileo, Alessandro Gronchi, Paolo G Casali, Marco A Pierotti, Elena Tamborini, Silvana Pilotti
Fluorescence in situ hybridization analysis and immunophenotyping of c-Kit/PDGFRA and Bcl-2 expression in gastrointestinal stromal tumors
2010 Aug;32(4):225-33
Abstract: To investigate c-Kit/PDGFRA genomic alterations, KIT-PDGFRA coexpression in gastrointestinal stromal tumors (GISTs) and the role of Bcl-2. - Roberto M Macchi, Carlo Patriarca, Michele Parente, Carmelo Arizzi
Processing the entire serous effusion: advantages with the 3-dimensional filtration unit
2010 Apr;32(2):116-9 - Hong-Xia Li, Min Li, Chang-Ling Li, Jian-Hui Ma, Ming-Rong Wang, Jianyu Rao, Qin-Jing Pan
ImmunoCyt and cytokeratin 20 immunocytochemistry as adjunct markers for urine cytologic detection of bladder cancer: a prospective study
2010 Feb;32(1):45-52
Abstract: To determine whether ImmunoCyt (uCyt+) immunofluorescence and cytokeratin 20 (CK20) immunocytochemistry add additional diagnostic value in the detection of urothelial carcinoma (UC) in samples of urine liquid-based cytology (LBC). - Nalan Nese, Gonca Kesici, Murat Lekili, Aydin Isisag
Urachal urothelial carcinoma diagnosed at a radical prostatectomy operation: a case report
Case Reports: 2010 Jun;32(3):174-7
Abstract: Urachal carcinomas are rare tumors, and the majority of them are adenocarcinomas. Up to now, only 21 urachal urothelial carcinomas (UCas) have been reported. Here, we describe a case of high grade UCa arising from the urachal remnants. - Heinz Reiske, Baoquan Sui, Huong Ung-Medoff, Robert Donahue, Wu-Bo Li, Michael Goldblatt, Limin Li, Michael S Kinch
Identification of annexin A13 as a regulator of chemotherapy resistance using random homozygous gene perturbation
2010 Apr;32(2):61-9
Abstract: To utilize a powerful new technology for target discovery, Random Homozygous Gene Perturbation (RHGP), and to identify novel targets that cause tumor cells to become chemoresistant. - Umit Karacayli, Ayper Kaya, Yavuz S Aydintug, Omer Gunhan
Ploidy status of odontogenic tumors with epithelial components
2010 Jun;32(3):146-50
Abstract: To evaluate the DNA ploidy status of different histologic types of odontogenic tumors (OTs) with epithelial components. - Marieta I Toma, Katrin Friedrich, Wolfdietrich Meyer, Michael Fröhner, Susanne Schneider, Manfred Wirth, Gustavo B Baretton
Correlation of centrosomal aberrations with cell differentiation and DNA ploidy in prostate cancer
2010 Feb;32(1):1-10
Abstract: To analyze the centrosomal abnormalities in correlation with DNA ploidy and clinicopathologic data in prostate cancer. - Eva Compérat, Lars Egevad, Philippe Camparo, Morgan Roupret, Christophe Vaessen, Alexander Valdman, Sara Jonmarker, Fréderique Capron, Olivier Cussenot, Fréderic Charlotte
Clinical significance of intratumoral CD8+ regulatory T cells in prostate carcinoma
2010 Feb;32(1):39-44
Abstract: To explore Foxp3, a member of the forkhead box family of transcription factors, which is a major gene for regulatory T (Treg) cell development of CD4+CD25+ or CD8+CD25+ phenotype. - Nalan Nese, Ali Rlza Kandiloglu, Gülin Simsek, Murat Lekili, Arzu Ozdamar, Arzu Catalkaya, Teoman Coskun
Comparison of the desmoplastic reaction and invading ability in invasive ductal carcinoma of the breast and prostatic adenocarcinoma based on the expression of heat shock protein 47 and fascin
Comparative Study: 2010 Apr;32(2):90-101
Abstract: To investigate the diversity within invasive ductal carcinoma (IDC) and prostatic adenocarcinoma (PCa) by evaluating immunohistochemical expression of heat shock protein 47 (HSP47) and fascin, the molecules that are related to desmoplasia and invasion, and analyze its correlation with clinicopathologic parameters. - Gaia Goteri, Antonio Zizzi, Simona Sabato, Antonello Costagliola, Daniela Stramazzotti, Corrado Rubini, Giancarlo Discepoli, Debora Capelli, Pietro Leoni
Immunostaining for nucleophosmin in bone marrow trephine biopsy specimens in acute myeloid leukemias
Clinical Trial: 2010 Aug;32(4):201-6
Abstract: To evaluate the technical feasibility of nucleophosmin (NPM) staining and the problems of interpretations by pathologists in an academic regional hospital in Italy. - Maurizio Vertemati, Alberto Quaglia, Ernesto Minola, Claudia Moscheni, Mara Cossa, Maria Goffredi, Laura Vizzotto
Morphometric analysis of dysplastic nodules in hepatitis C virus-related liver cirrhosis: comparison with cirrhotic and large regenerative nodules
Comparative Study: 2010 Apr;32(2):106-13
Abstract: To apply a computerized morphometric model to evaluate and quantify the morphologic features, including hepatic progenitor cells, in large regenerative nodules (LRN) and high grade dysplastic nodules (DN) in hepatitis C virus (HCV)-related cirrhosis. - Kathrin Brunner, Claude A Fischer, Oliver Driemel, Arndt Hartmann, Gero Brockhoff, Stephan Schwarz
EGFR (HER) family protein expression and cytogenetics in 219 squamous cell carcinomas of the upper respiratory tract: ERBB2 overexpression independent prediction of poor prognosis
2010 Apr;32(2):78-89
Abstract: To retrospectively evaluate the prognostic impact of gene status and protein expression of receptor tyrosine kinases of the HER (human epidermal growth factor receptor related) family in relation to established clinicopathologic parameters in squamous cell carcinomas of the upper respiratory tract. - Jesse S Voss, Benjamin R Kipp, Michael B Campion, Irina A Sokolova, Michael R Henry, Kevin C Halling, Amy C Clayton
Assessment of fluorescence in situ hybridization and hybrid capture 2 analyses of cervical cytology specimens diagnosed as low grade squamous intraepithelial lesion for the detection of high grade cervical intraepithelial neoplasia
Comparative Study: 2010 Jun;32(3):121-30
Abstract: To assess Hybrid Capture 2 (HC2) and fluorescence in situ hybridization (FISH) for the detection of cervical intraepithelial neoplasia 2 or worse (CIN 2+) in patients with a cytologic diagnosis of low grade squamous intraepithelial lesion (LSIL). - Swaroop S Singh, Michael J Ray, Warren Davis, James R Marshall, Wael A Sakr, James L Mohler
Manual and automated systems in the analysis of images from prostate tissue microarray cores
Comparative Study: 2010 Dec;32(6):311-9
Abstract: To compare manual and automated image analysis systems in morphologic analysis of nuclei from benign prostate, high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate cancer (CaP). Morphologic features derived using automated image analysis systems may be more objective and reproducible than manual systems, which require humans to segment nuclei from histologic images. - Claude Lesty, Sylvie Baudet, Frederic Charlotte
A study of bone marrow neoangiogenesis in chronic lymphocytic leukemia patients
2010 Feb;32(1):11-23
Abstract: To use a purely geometric data-unravelling method to identify, without a priori, direct links of neoangiogenesis with known clinicobiologic variables in 23 untreated chronic lymphocytic leukemia (CLL) patients at the time of marrow sampling. - Massimo Re, Giuseppe Magliulo, Eleonora Salvolini, Monia Orciani, Federico Maria Gioacchini, Gaia Goteri, Corrado Rubini
Prognostic significance of p53 and KAI-1 expression in patients with laryngeal squamous cell carcinoma
2010 Oct;32(5):247-53
Abstract: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma. - Vanessa Dixon, Mauro Tambasco
Effects of image resolution and noise on estimating the fractal dimension of tissue specimens
2010 Oct;32(5):269-79
Abstract: To investigate the effects of imaging system noise and resolution on the ability to estimate and distinguish relative differences in the fractal dimension of tissue specimens. - Jin-qiu Sheng, Shi-rong Li, Hui Su, Jian-sheng Li, Zi-qin Sun, Zi-tao Wu, Xia Wu, Chang-hong Xia, Jianyu Rao
Fecal cytology in conjunction with immunofecal occult blood test for colorectal cancer screening
2010 Jun;32(3):131-5
Abstract: To develop a simple method to extract and analyze the cytomorphology of epithelial cells from fecal samples and to compare the efficacy of fecal cytology with the immunofecal occult blood test (IFOBT) in colorectal cancer screening. - Vladimir Kirillov, Lydmila Akimova
Regression analysis of the initial karyometric data on tumor cells in ductal carcinoma and fibroadenoma of the mammary gland
2010 Apr;32(2):102-5
Abstract: To reveal the differences in the parameters of the second order regression curve with a cluster of experimental points on scattergrams showing the dependence of the perimeter on the area of tumor cell nuclei between ductal carcinoma and fibroadenoma of the mammary gland. - Oliver Driemel, Niko Escher, Günther Ernst, Christian Melle, Ferdinand von Eggeling
S100A8 cellular distribution in normal epithelium, hyperplasia, dysplasia and squamous cell carcinoma and its concentration in serum
2010 Aug;32(4):219-24
Abstract: To investigate the function of S100A8, a member of the calcium-binding S100 protein family, in oral tumorigenesis. We analyzed its cellular distribution and its serum level in patients with squamous cell carcinoma and normal controls. - Teresa Pusiol, Ilaria Franceschetti, Michele Scialpi, Irene Piscioli, Maria Lucia Tardio
Electron microscopy: the gold standard in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma
Comment: 2010 Feb;32(1):58-60 - Yilmaz Altuner, Adnan Ayhanci, Kismet Civi, Hilmi Ozden, Derya Ustuner, M Cengiz Ustuner, Hulyam Kurt
Protective effects of N(G)-nitro-L-arginine methyl ester and metallothioneins on excess nitric oxide toxicity in trinitrobenzene sulfonic acid-induced rat colitis
2010 Jun;32(3):166-73
Abstract: To evaluate the protective effects of N(G)-nitro-L-arginine methyl ester (L-NAME) and metallothioneins on excess nitric oxide toxicity in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis. - Aziza Nassar, Christine M Norton, Diane Lawson, Cynthia Cohen
Image cytometric validation of breast carcinoma markers (ER, HER2 and MIB-1) using tissue microarrays: rabbit monoclonal vs. FDA-approved antibodies
2010 Aug;32(4):192-200
Abstract: To use the ACIS III (Dako, Carpinteria, California, U.S.A.) with tissue microarrays (TMAs) to compare rabbit monoclonal antibodies (RMab) for ER, HER2, and MIB-1 with FDA-approved monoclonal (FMab) and polyclonal (FPab) antibodies. - Dansheng Song, Inna Fedorenko, Marianna Pensky, Wei Qian, Melvyn S Tockman, Tatyana A Zhukov
Quantificational and statistical analysis of the differences in centrosomal features of untreated lung cancer cells and normal cells
2010 Oct;32(5):280-90
Abstract: To distinguish untreated lung cancer cells from normal cells through quantitative analysis and statistical inference of centrosomal features extracted from cell images. - Weiqiang Zheng, Jane E Armes, John Slavin, Yuzhao Zhu, Canrong Ni
Preliminary comparison of tumor biologic factors in breast carcinomas from Australian and Chinese women
Comparative Study: 2010 Jun;32(3):155-60
Abstract: To compare the morphologic and immunohistochemical properties of breast carcinomas from Chinese and Australian women in order to define possible biologic differences between these carcinomas. - Hans Ivar Hanevik, Bjørn Logi Isfoss, Anette Bergh, Mette Friberg, Jarl A Kahn
Improved diagnostic accuracy of testicular biopsies for infertility through simplified criteria and a dedicated pathologist
2010 Aug;32(4):214-8
Abstract: To examine whether simplified histopathologic criteria and a dedicated pathologist could influence the diagnostic accuracy of testicular biopsy. - Tomasz Markiewicz, Bartlomiej Grala, Wojciech Kozlowski, Stanislaw Osowski
Computer system for cell counting in selected brain tumors at Ki-67 immunohistochemical staining
2010 Dec;32(6):323-32
Abstract: To present a computerized system for cell counting in histopathologic slides of meningioma and oligodendroglioma stained immunohistochemically against Ki-67 antigen and discuss the variability of tumor cell numbers in the field of view of analyzed neoplasms to standardize tumor cellularity. - Mansooreh Bagheri, Behnam Moein Jahromi, Mandana Bagheri, Afshin Borhani Haghighi, Ali Noorafshan, Perikala Vijai Kumar, Gholamhossein Ranjbar Omrani
A pilot study on lipolytic effect of subcutaneous botulinum toxin injection in rabbits
2010 Aug;32(4):186-91
Abstract: To determine whether botulinum toxin type A (BTX-A) exerts a lipolytic effect by interfering with acetylcholine transmission at the cholinergic parasympathetic nerve endings. - Fernando Casco, Matilde Illanes Moreno, Ricardo González Cámpora, Ana Moreno, Hugo Galera Ruiz
Spindle epithelial tumor with thymuslike differentiation in a 2-year-old boy: a case report
Case Reports: 2010 Feb;32(1):53-7
Abstract: The spindle epithelial tumor with thymuslike differentiation (SETTLE) is a rare thyroid tumor believed to be derived from ectopic thymus tissue or the embryonic remnants of branchial pouches, which displays primitive thymic differentiation. - Ana Mozos, Manel Sole, Rosa Miquel, Ana Petit, Alfons Nadal, Pedro Luis Fernández
Usefulness and limitations of alpha-methylacyl-CoA racemase expression in the hepatobiliary system and pancreas: a wide tissue microarray analysis of normal and neoplastic epithelia
2010 Oct;32(5):261-8
Abstract: To establish the frequency, significance and clinical utility of alpha-methylacyl-CoA racemase (AMACR) expression in the hepatobiliary system by performing a wide immunohistochemical screening of AMACR expression. - Aldo V Bono, Tania Pannellini, Marcella Liberatore, Rodolfo Montironi, Sergio Cosciani Cunico, Liang Cheng, Francesco Sasso, Piero Musiani, Manuela Iezzi
Sorafenib's inhibition of prostate cancer growth in transgenic adenocarcinoma mouse prostate mice and its differential effects on endothelial and pericyte growth during tumor angiogenesis
2010 Jun;32(3):136-45
Abstract: To evaluate Sorafenib's efficacy (60 mg/kg/d per os) in preventing the transformation of high grade prostate intraepithelial neoplasia (HGPIN) into adenocarcinoma (ADC) and in inhibiting the onset and progression of poorly differentiated carcinoma (PDC) in transgenic adenocarcinoma mouse prostate (TRAMP) mice. - Kamel Belkacem-Boussaid, Michael Pennell, Gerard Lozanski, Arwa Shana'ah, Metin Gurcan
Computer-aided classification of centroblast cells in follicular lymphoma
2010 Oct;32(5):254-60
Abstract: To distinguish centroblast cells from non-centroblast cells using a novel automated method in follicular lymphoma cases and measure its performance on cases obtained by a consensus of six pathologists. - Jasleen Kaur, Pranab Dey
Mean nuclear volume in complex atypical hyperplasia and adenocarcinoma of the endometrium
2010 Oct;32(5):291-4
Abstract: To explore the possible role of mean nuclear volume (MNV) in differentiating complex atypical hyperplasia (CAH) from well-differentiated adenocarcinoma (WDAC) of the endometrium. - Elva I Cortés-Gutiérrez, Martha I Dávila-Rodríguez, Estela A Zamudio-González, Miguel E Aguado-Barrera, Javier Vargas-Villarreal, Ricardo M Cerda-Flores
DNA damage in Mexican women with cervical dysplasia evaluated by comet assay
Clinical Trial: 2010 Aug;32(4):207-13
Abstract: To investigate the association between the progressive stage of cervical dysplasia and DNA damage by comet assay. - Radostin Simeonov, Galina Simeonova
Quantitative analysis in canine cutaneous mast cell tumors
2010 Jun;32(3):178-81 - Amit Kumar Yadav, Kiran Mishra, Sarla Agarwal, Anup Mohta
Role of computerized morphometric analysis in the diagnosis of Hirschsprung's disease
2010 Apr;32(2):114-6 - Niels Halama, Inka Zoernig, Anna Spille, Sara Michel, Matthias Kloor, Silke Grauling-Halama, Kathi Westphal, Peter Schirmacher, Dirk Jäger, Niels Grabe
Quantification of prognostic immune cell markers in colorectal cancer using whole slide imaging tumor maps
2010 Dec;32(6):333-40
Abstract: To analyze intratumoral heterogeneity of immune cells and the resulting impact of heterogeneity on the level of individual patient prediction. - Jabed Iqbal, Ting Liu, Beth Mapow, Vanlila K Swami, J Steve Hou
Importance of flow cytometric analysis of serous effusions in the diagnosis of hematopoietic neoplasms in patients with prior hematopoietic malignancies
2010 Jun;32(3):161-5
Abstract: To determine the criteria for the use of immunophenotyping by flow cytometry (FCM) in the diagnosis of hematopoietic lesions. - Gwendolyn J Godfrey, Rania Bakkar, Hanan Farghaly
Mature cystic teratoma of the appendix: a case report
Case Reports: 2010 Oct;32(5):295-8
Abstract: Teratomas very rarely arise from the appendix. To our knowledge, only one prior case of mature teratoma involving the appendix has been reported in the medical literature. - Pranab Dey, Nidhi Sharma, Swapan Samanta
Fractal dimension of cervical intraepithelial lesions on cytology smear
2010 Dec;32(6):320-2
Abstract: To explore the role of fractal dimension (FD) in distinguishing normal and different grades of cervical intraepithelial lesions. - Mehmet Kefeli, Ilkser Akpolat, Arzu Yildirim, Ahmet Tevfik Sunter, Bedri Kandemir
Morphometric analysis in cytologic evaluation of papillary thyroid carcinoma
2010 Aug;32(4):234-8
Abstract: To compare the morphometric features of papillary carcinomas with follicular neoplasias and benign lesions and to determine the potential role of nuclear morphometric features in their differential diagnosis.