Volume 25 (2009) Issue 1 - Issue 6
- Pranab Dey
Nuclear margin irregularity and cancer: a review
Review: 2009 Oct;31(5):345-52
Abstract: Nuclear margin irregularity is an important diagnostic feature of malignant cells. The exact cause of nuclear margin irregularity is not fully understood. The distortion of the nuclear envelope is probably the major factor in nuclear margin irregularity. - Peter H Bartels, Hubert G Bartels
Discriminant analysis
2009 Oct;31(5):247-54
Abstract: To present a fully worked numerical example for the derivation of a discriminant function in order to provide insight into the processing steps and origin of the function coefficients. - Peter H Bartels, Rodolfo Montironi
Quantitative histopathology: the evolution of a scientific field
Editorial: 2009 Feb;31(1):1-4 - Judit Pallares, Maria Santacana, Soraya Puente, Susana Lopez, Andree Yeramian, Nuria Eritja, Anabel Sorolla, David Llobet, Xavier Dolcet, Xavier Matias-Guiu
A review of the applications of tissue microarray technology in understanding the molecular features of endometrial carcinoma
Review: 2009 Aug;31(4):217-26
Abstract: To review the literature regarding the use of tissue microarray (TMA) technology in understanding the biology, diagnosis and prognosis of endometrial carcinoma (EC). - Fabio A Ito, Kazuhiro Ito, Ricardo D Coletta, Edgard Graner, Oslei P de Almeida, Márcio A Lopes
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67
2009 Oct;31(5):280-7
Abstract: To analyze the expression of ErbB-1 (Her-1 or EGFR), ErbB-2 (Her-2 or neu), ErbB-3 (Her-3) and ErbB-4 (Her-4) and their correlation in 3 different types of salivary gland tumors. - Matteo Brunelli, Brett Delahunt, Vincenzo Ficarra, Stefano Gobbo, Albino Eccher, Paolo Cossu-Rocca, Filiberto Zattoni, Liang Cheng, John N Eble, Guido Martignoni
Utility of tissue microarrays for assessment of chromosomal abnormalities in chromophobe renal cell carcinoma
Comparative Study: 2009 Dec;31(6):401-9
Abstract: To compare the results of numerical chromosomal changes in chromophobe renal cell carcinoma obtained from whole tissue sections with those of tissue microarrays. - Peter Bartels, Michael Yozwiak, Janine Einspahr, Kathylynn Saboda, Yun Liu, Christine Brooks, Hubert Bartels, David S Alberts
Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry
Clinical Trial: 2009 Dec;31(6):355-66
Abstract: To determine whether low-dose topical applications of difluoromethylornithine (DFMO) with or without Triamcinolone (Fougena, Melville, New York, U.S.A.) to moderately sun-damaged skin with actinic skin keratoses are efficacious. - Toby C Cornish, Marc K Halushka
Color deconvolution for the analysis of tissue microarrays
2009 Oct;31(5):304-12
Abstract: To analyze tissue microarrays (TMAs) using color deconvolution, a method for separating component dyes in digital images, and compare the results to observer scoring. - Tina Y Fodrie, Stephen D Allen, Deborah E Blue, Patty Gary, Liang Cheng
Evaluation of a real-time polymerase chain reaction assay using analyte-specific reagents for detection of methicillin-resistant Staphylococcus aureus nasal carriage
Comparative Study: 2009 Dec;31(6):410-6
Abstract: To validate a real-time polymerase chain reaction (PCR) assay for the detection of methicillin-resistant Staphylococcus aureus (MRSA) that is capable of accommodating 30 patient samples in a single batch without compromising the level of sensitivity and specificity associated with PCR testing. - Robert S Krouse, David S Alberts, Anil R Prasad, Michael Yozwiak, Hubert G Bartels, Yun Liu, Peter H Bartels
Progression of skin lesions from normal skin to squamous cell carcinoma
2009 Feb;31(1):17-25
Abstract: To assess the changes in the nuclear chromatin pattern concomitant with progressive sun damage in skin biopsies ranging from sun-exposed, normal-appearing skin to squamous cell carcinoma (SCC). - Wendy A Wells, Xin Wang, Charles P Daghlian, Keith D Paulsen, Brian W Pogue
Phase contrast microscopy analysis of breast tissue: differences in benign vs. malignant epithelium and stroma
2009 Aug;31(4):197-207
Abstract: To assess how optical scatter properties in breast tissue, as measured by phase contrast microscopy and interpreted pathophysiologically, might be exploited as a diagnostic tool to differentiate cancer from benign tissue. - Vrushali R Korde, Hubert Bartels, Jennifer Barton, James Ranger-Moore
Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis
2009 Apr;31(2):83-9
Abstract: To automatically segment cell nuclei in histology images of bladder and skin tissue for karyometric analysis. - Lars Egevad, Ferran Algaba, Dan M Berney, Liliane Boccon-Gibod, David F Griffiths, Antonio Lopez-Beltran, Gregor Mikuz, Murali Varma, Rodolfo Montironi; European Network of Uropathology
The European Network of Uropathology: a novel mechanism for communication between pathologists
2009 Apr;31(2):90-5
Abstract: In pathology there is a need to rapidly disseminate professional information to the appropriate target groups. This is a surprisingly difficult task on an international level. Therefore, the European Network of Uropathology (ENUP) was recently organized by the Uropathology Working Group of the European Society of Pathology. - Irene Lambrinoudaki, Areti Augoulea, Maria Creatsa, Nikolaos Vlachos, George Christodoulakos, Constantinos Papadias
Endometriosis and other benign and malignant müllerian lesions in pelvic and extrapelvic organs
2009 Jun;31(3):170-6
Abstract: To conduct a retrospective study on case reports found in literature across the world on benign müllerian lesions of the urogenital tract and on cases of malignant transformation from müllerian duct remnants in order to better understand these rare anatomopathologic entities and to avoid overdiagnosis and overtreatment. - Michal Heger, Isabelle I Salles, Wiebe van Vuure, Hans Deckmyn, Johan F Beek
Fluorescent labeling of platelets with polyanionic fluorescein derivatives
2009 Aug;31(4):227-32
Abstract: To investigate whether polyanionic fluorescein derivatives are capable of labeling resting and activated hamster and human platelets. - Noriko Kato, Teiichi Motoyama
Expression of hepatocyte nuclear factor-1beta in human urogenital tract during the embryonic stage
2009 Feb;31(1):34-40
Abstract: To investigate hepatocyte nuclear factor-1beta (HNF-1beta) expression in the human urogenital tract during the embryonic stage. - Carlos Saul, Cibele Canali, Claudio R Teixeira, Artur A Parada, Joao Carlos Prolla, Vinicius D da Silva
Digital morphometric characterization of mucosal surface lesion patterns under magnification colonoscopy
2009 Dec;31(6):375-9
Abstract: To study quantified mucosal surface patterns of digitized colonoscopic images obtained with 17-40x magnification and chromoscopy of hyperplastic, adenomatous lesions and adenocarcinomas confirmed by histology. - Maurizio Colecchia, Nicola Nicolai, Piercesare Secchi, Gaetano Bandieramonte, Anna Maria Paganoni, Laura Maria Sangalli, Giorgio Pizzocaro, Luigi Piva, Roberto Salvioni
pT1 penile squamous cell carcinoma: a clinicopathologic study of 56 cases treated by CO2 laser therapy
2009 Jun;31(3):153-60
Abstract: To evaluate the pathologic characteristics that are associated with outcomes in pT1 penile squamous cell carcinoma (SCC) treated with laser excision. - Utku Ateş, Yiğit Uyanikgil, Meral Baka, Ebru Ozdaş, Songül Biçer, Gürsel Ergen
Subacute effect of 2,4-dichlorophenoxyacetic acid on rat liver tissue: histochemical and immunohistochemical study
2009 Oct;31(5):354-62 - Zlatko Marusić, Hrvoje Cupić, Bozo Kruslin, Davor Tomas, Milan Milosević, Gregor Mikuz
Tumor-associated tissue eosinophilia and inflammation in pTa and pT1 papillary urothelial carcinoma of the bladder
2009 Aug;31(4):239-41 - Krzysztof Okoń, Anna Sińczak-Kuta, Jerzy Stachura
Renal papillary carcinoma classification into subtypes may be reproduced by nuclear morphometry
2009 Apr;31(2):109-17
Abstract: To analyze relationships between nuclear features of papillary renal cell carcinoma (PapRCC) subtypes. - Adhemar Longatto Filho, Alberto Emanuel Pinheiro Gonçalves, Olga Martinho, Fernando C Schmitt, Rui Manuel Reis
Liquid-based cytology in DNA-based molecular research: viability and potential application
2009 Dec;31(6):395-400
Abstract: To evaluate the effectiveness of UCM and PreservCyt liquid media in molecular analysis using exfoliated oral cells and analyze Tp53 codon 72 extracted from these cells. - Burcin Tuna, Mehtat Unlu, Guven Aslan, Mustafa Secil, Kutsal Yorukoglu
Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies
2009 Apr;31(2):118-22
Abstract: To determine the ability of p63 reactivity to confirm the diagnosis of urothelial carcinomas (UCs) that present clinically as kidney masses and to determine the association of p63 expression with clinicopathologic features in UCs. - Vesna Ivanović, Nasta Dedović-Tanić, Zorka Milovanović, Silvana Lukić, Srdjan Nikolić, Vladimir Baltić, Bratislav Stojiljković, Nikola Budisin, Kiril Savovski, Miroslav Demajo, Bogomir Dimitrijević
Quantification of transforming growth factor beta 1 levels in metastatic axillary lymph node tissue extracts from breast cancer patients: a new specimen source
2009 Oct;31(5):288-95
Abstract: To use cytoplasmic tissue extract as a new specimen source to quantify transforming growth factor beta 1 (TGFbeta1) protein in metastatic axillary lymph node tissue (ALNT) of breast cancer (BC) patients and to confirm the feasibility of this approach in a prospective pilot study on a subgroup of patients with invasive BC. - Jean Naples, Sumit Isharwal, Clive J Shiff, Kwabena M Bosompem, Robert W Veltri
Clinical utility of squamous and transitional nuclear structure alterations induced by Schistosoma haematobium in chronically infected adults with bladder damage verified by ultrasound in Ghana
2009 Jun;31(3):143-52
Abstract: To evaluate the clinical utility of quantitative nuclear morphometry--i.e., alteration in nuclear size/shape, DNA content and chromatin structure-of intact cells obtained from the sediment of urine specimens collected from people living in an area highly endemic for Schistosoma haematobium in Ghana. - Edmond Kahn, Sophie Pelloux, Mauhamad Baarine, Taoufik Khalfaoui, Kévin Ragot, Frédérique Frouin, Jean-Marc Riedinger, Yves Tourneur, Gérard Lizard
Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences
2009 Dec;31(6):380-94
Abstract: To evaluate the capture of nanoparticles (quantum dots [QDs], fluorospheres) by nonbeating mouse cardiac cells (HL1-NB) cultured without or with 7-ketocholesterol (7KC) found at an increased level in the plasma of atherosclerotic patients and to simultaneously analyze their cytotoxic, proinflammatory and oxidative properties. - Narender Kumar, Neelam Varma, Subhash Varma, Pankaj Malhotra
Study of diagnostic and prognostic parameters (including flow cytometry) in chronic lymphoproliferative disorders: the Indian perspective
2009 Oct;31(5):296-303
Abstract: To assess for chronic lymphoproliferative disorders (CLPD) using several diagnostic and prognostic parameters, including cell morphology, immunologic markers and molecular and cytogenetic investigations, some of which had not been used in the assessment of patients in India. - Jesse S Voss, Benjamin R Kipp, Michael B Campion, Irina A Sokolova, Michael R Henry, Kevin C Halling, Amy C Clayton
Comparison of fluorescence in situ hybridization, hybrid capture 2 and polymerase chain reaction for the detection of high-risk human papillomavirus in cervical cytology specimens
Comparative Study: 2009 Aug;31(4):208-16
Abstract: To compare a recently developed fluorescence in situ hybridization (FISH) high-risk human papillomavirus (HR-HPV) assay to Hybrid Capture 2 (HC2) (Digene Corporation, Gaithersburg, Maryland, U.S.A.) and polymerase chain reaction (PCR) for the detection of HR-HPV subtypes in cervical cytology specimens. - Luhana Gedoz, Paula Luce Bohrer, Ricardo Losekan Paiva, João Batista Burzlaff, Cassiano Kuchenbecker Rösing, Manoel Sant'Ana Filho, Pantelis Varvaki Rados
Validation of cytopathology as a technique for analysis of epithelial cell maturation in oral mucosa of smokers and nonsmokers
2009 Apr;31(2):96-100
Abstract: To validate quantitative analysis of epithelial cells in oral mucosa smears of smokers and nonsmokers. - Alexander Valdman, Lars Häggarth, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi, Peter Ekman, Lars Egevad
Expression of redox pathway enzymes in human prostatic tissue
2009 Dec;31(6):367-74
Abstract: To evaluate the involvement of thioredoxin reductase (TxnR), thioredoxin (Trx) and peroxiredoxins (Prdx) in prostate cancer (PCa) and to assess the potential prognostic importance of these redox-regulated pathways. - Renzo Ranaldi, Doriana Morichetti, Gaia Goteri, Ascanio Martino
Immature teratoma of the mediastinum arising in ectopic thyroid tissue: a case report
Case Reports: 2009 Aug;31(4):233-8
Abstract: Papillary carcinoma can arise from ectopic thyroid tissue, but teratoma have not been described. Differentiation into thyroid follicles does not occur in mediastinal teratomas. - Ika Kardum-Skelin, Ozren Jaksic, Slobodanka Ostojic Kolonic, Radovan Vrhovac, Iris Fabijanic, Biljana Jelic-Puskaric, Marina Milas, Branimir Jaksic
New parameters of diploid histogram of image DNA cytometry and newly characterized types of nucleolar organizer region structures in defining the proliferative-kinetic index in chronic leukemic lymphoproliferative disorders
2009 Oct;31(5):340-4
Abstract: To introduce new parameters of diploid histogram of image DNA cytometry and new types of silver-stained nucleolar organizer regions (AgNORs) and to validate resulting proliferative-kinetic index (PKI) in a prognostic study of patients with chronic leukemic lymphoproliferative disorders (CLLPD). - Burçin Tuna, Kutsal Yorukoglu, Roberta Mazzucchelli, Ugur Mungan, Mustafa Secil, Rodolfo Montironi, Ziya Kirkali
Ezrin immunoreactivity in renal cell carcinomas
2009 Oct;31(5):340-4
Abstract: To determine ezrin's association with clinicopathologic features and to investigate the possible effects of the presence of ezrin on the differential diagnosis of subtypes of renal cell carcinoma (RCC). - Peter H Bartels, Rodolfo Montironi, Marina Scarpelli, Hubert G Bartels, David S Alberts
Knowledge discovery processing and data mining in karyometry
2009 Jun;31(3):125-36
Abstract: To present the rationale for applying different sequences of multivariate analysis algorithms to determine if and where, in the large and high-dimensional data space, events have led to change in karyometric features. - Sara Giorgini, Francesca Barbisan, Doriana Morichetti, Roberta Mazzucchelli, Daniela Marzioni
PUNLMP or not PUNLMP? This is the problem
2009 Jun;31(3):184-5 - Adriana Worschech, Luciana Meirelles, Athanase Billis
Expression of alpha-methylacyl coenzyme A racemase in partial and complete focal atrophy on prostate needle biopsies
2009 Dec;31(6):424-31
Abstract: To describe the behavior of alpha-methylacyl coenzyme A racemase (AMACR) in focal atrophy including all subtypes. Focal prostatic atrophy is the benign lesion that most frequently mimicks adenocarcinoma particularly the partial variant. - Jie Gao, Michael A McNutt, Weining Yi, Jin Chen, Jiang Gu
Quantitative morphometry by image analysis of normal, hyperplastic and cancerous ductal breasts
2009 Oct;31(5):255-61
Abstract: To analyze a number of quantitative variables in ductal epithelial breast proliferations and test them against diagnoses established by standard histologic and cytologic criteria in order to determine which variables are useful in discriminating between histologic diagnoses. - Konradin Metze, Randall L Adam, Joyce R Vido, Irene G H Lorand-Metze
The influence of staining characteristics on nuclear texture features in cytology
2009 Aug;31(4):241-6 - Ahmet Taylan Yazici, Ismail Malkoç, B Zuhal Altunkaynak, Ali Riza Erdoğan, M Dumlu Aydin, Senol Dane, Serpil Can, Kenan Gümüştekin, Bünyamin Unal
Number of axons in the right and left optic nerves of right-pawed and left-pawed rats: a stereologic study
Comparative Study: 2009 Jun;31(3):177-83
Abstract: To compare the number of axons in the right and left optic nerves of right- and left-pawed rats. - Alka Bhatia, Ruth Shifa Eckka, Pranab Dey
Fractal dimensions of reactive mesothelial cells and malignant cells in ascitic fluid cytology
2009 Oct;31(5):353-4 - Tomasz Markiewicz, Piotr Wisniewski, Stanislaw Osowski, Janusz Patera, Wojciech Kozlowski, Robert Koktysz
Comparative analysis of methods for accurate recognition of cells through nuclei staining of Ki-67 in neuroblastoma and estrogen/progesterone status staining in breast cancer
2009 Feb;31(1):49-62
Abstract: To compare 2 automatic systems for the recognition and counting of 2 different families of cells through nuclei staining: Ki-67 in neuroblastoma and estrogen/progesterone (ER/PR) status staining in breast cancer. - Anca Reschner, Helena Harlin, Brett Laven, Fredrik Eriksson, Pavel Pisa, Lars Egevad
Expression of immunomodulating genes in prostate cancer and benign prostatic tissue
2009 Apr;31(2):74-82
Abstract: To investigate the expression of immunomodulating genes in prostate cancer and benign prostatic tissue. - Lorenzo Lo Muzio, Lucio Lo Russo, Giuseppe Pannone, Angela Santoro, Rosalia Leonardi, Rosario Serpico, Alberto Gasparoni, Pantaleo Bufo
Expression of beta-catenin in human tooth germ
2009 Oct;31(5):324-31
Abstract: To evaluate beta-catenin expression in human tooth germ development. - Peter H Bartels, Hubert G Bartels, David S Alberts
Karyometry: correction algorithm for differences in staining
2009 Apr;31(2):63-73
Abstract: To describe an algorithm that allows the correction of differences in staining of histopathologic sections while preserving chromatin texture. - Shanon Lacy, Antonio Lopez-Beltran, Gregory T MacLennan, Stephanie R Foster, Rodolfo Montironi, Liang Cheng
Molecular pathogenesis of urothelial carcinoma: the clinical utility of emerging new biomarkers and future molecular classification of bladder cancer
2009 Feb;31(1):5-16
Abstract: Bladder cancer remains one of the most common and expensive cancers to treat worldwide. Numerous molecular markers are being investigated as possible ways to decrease health care costs, increase patient survival and prognosis, and increase sensitivity in screening tests. - George Chelidonis, Nikolaos Kavantzas, Efstratios Patsouris, Eumorfia Pagaki, Anna-Maria Athanasiadou, George Agrogiannis, Pauline Athanasiadou
DNA ploidy, E-cadherin, beta-catenin expression and their clinicopathologic significance in imprints of non-small cell lung cancer
2009 Oct;31(5):332-9
Abstract: To evaluate, in imprints of resected non-small cell lung cancers (NSCLCs), the relationship between DNA ploidy and E-cadherin/beta-catenin expression with classical prognostic factors. - Alessandra Filosa, Andrea Fabiani
Dr. Donald Floyd Gleason's historic, immense contribution to urologic pathology
2009 Apr;31(2):123-4 - Spiros Kostopoulos, Dimitris Glotsos, Dionisis Cavouras, Antonis Daskalakis, Ioannis Kalatzis, Pantelis Georgiadis, Panagiotis Bougioukos, Panagiota Ravazoula, George Nikiforidis
Computer-based association of the texture of expressed estrogen receptor nuclei with histologic grade using immunohistochemically-stained breast carcinomas
2009 Aug;31(4):187-96
Abstract: To investigate the potential correlation between estrogen receptor (ER) texture and histologic grade in breast carcinomas. - Ruchika Gupta, Sompal Singh
A comparative analysis of manual point-counting method and automated pixel-counting method of area percentage estimation on placenta
Comparative Study: 2009 Feb;31(1):26-33
Abstract: To obtain the coefficient of variation (CV) of systematic point counting performed on sections of placenta; to obtain the optimal minimum CV achievable by systematic point-counting method for placentas; and to compare the manual point-counting and automatic pixel-counting methods and obtain a mean bias and 95% limits of agreement between them. - Rosalia Ricco, Anna Maria Dalena, Tiziana Valente, Teresa Lettini, Francesca Sanguedolce, Antonella R Pesce Delfino
Quantitative study of placental villi in trisomy by analytical morphometry
2009 Feb;31(1):41-8
Abstract: To assess the relationship between morphologic features of placental villi and the occurrence of trisomy. - Dimitris Glotsos, Pantelis Georgiadis, Spiros Kostopoulos, Antonis Daskalakis, Ioannis Kalatzis, Panagiota Ravazoula, Dionisis Cavouras
A pilot study investigating the minimum requirements necessary for grading astrocytomas remotely
2009 Oct;31(5):262-8
Abstract: To investigate the minimum requirements necessary for remote grading astrocytomas in terms of selected static images and descriptive histologic characteristics. - Katrin Friedrich, Anja von Heydebreck, Gunter Haroske, Jens Scheithauer, Wolfdietrich Meyer, Klaus Dietmar Kunze, Gustavo Baretton
Comparative genomic hybridization-based oncogenetic tree model for genetic classification of breast cancer
2009 Apr;31(2):101-8
Abstract: To describe a genetic progression pathway in breast cancer by a maximum likelihood-based tree model representing the dependencies between chromosomal imbalances. - Vinita Agrawal, Ramesh K Gupta, Manoj Jain
Glomerular retrieval by cell block preparation of preservative fluid: an adjunct to biopsy diagnosis
2009 Oct;31(5):276-9
Abstract: To investigate the possibility of glomerular retrieval from formalin left in biopsy vials and to evaluate its diagnostic value and accuracy. - Einas Alkuwari, Karim Khetani, Nandini Dendukuri, Liangliang Wang, Manon Auger
Quantitative assessment of nuclear grooves in fine needle aspirates of the thyroid: a retrospective cytohistologic study of 94 cases
2009 Jun;31(3):161-9
Abstract: To quantify the association between the percentage of nuclear grooves and papillary thyroid carcinoma (PTC) in fine needle aspirates (FNAs) of the thyroid. - Mario Scartozzi, Italo Bearzi, Alessandra Mandolesi, Eva Galizia, Chiara Pierantoni, Fotios Loupakis, Rossana Berardi, Alberto Zaniboni, Antonello Quadri, Fausto Zorzi, Simona Biagetti, Cristian Loretelli, Tommasina Biscotti, Roberto Labianca, Gianluca Masi, Alfredo Falcone, Stefano Cascinu
Epidermal growth factor receptor gene promoter methylation in primary colorectal tumors and corresponding metastatic sites: a new perspective for an "old" therapeutic target
2009 Dec;31(6):417-23
Abstract: To clarify the role of epidermal growth factor receptor (EGFR) promoter methylation in primary colorectal cancers and corresponding metastases and its relationship to EGFR expression. - Adhemar Longatto-Filho, Luís Filipe Gomes Malheiro, Fernanda Milanezi, Celine Pinheiro, Fátima Baltazar, Fernando C Schmitt, Rodolfo Montironi
Lymphatic vessel density in the normal-looking columnar epithelium adjacent to and distant from prostatic intraepithelial neoplasia and prostate cancer assessed in whole-mount sections
2009 Oct;31(5):269-75
Abstract: To evaluate the lymphatic vessel density (LVD) in radical prostatectomy using the lymphatic marker D2-40 and analyze if LVD is variable within the whole-mounting samples of prostatectomy in different areas of carcinoma, high- and low-grade prostatic intraepithelial neoplasia and nodular hyperplasia. - Robert Rosenblatt, Alexander Valdman, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi, Peter Ekman, Lars Egevad
Endothelin-1 expression in prostate cancer and high grade prostatic intraepithelial neoplasia
2009 Jun;31(3):137-42
Abstract: To investigate the prognostic value of endothelin-1 (ET-1), a vasoconstrictor involved in differentiation and growth of cancer, in prostate cancer.