Volume 24 (2008) Issue 1 - Issue 6
- Rodolfo Montironi, Roberta Mazzucchelli
Reflection on the past, present and future of analytical and quantitative cytology and histology
Editorial: 2008 Oct;30(5):249-53 - Gaia Goteri, Serena Rupoli, Stefano Pulini, Angela Tassetti, Pietro Leoni
Prognostic markers in mycosis fungoides
Editorial: 2008 Aug;30(4):187-9 - Hemamali Samaratunga, Brett Delahunt
Ductal adenocarcinoma of the prostate: current opinion and controversies
Review: 2008 Aug;30(4):237-46
Abstract: To evaluate the morphologic spectrum and clinical significance of ductal adenocarcinoma of the prostate (DAP). - Sokol Petushi, Jeffrey Marker, Jasper Zhang, Weizhong Zhu, David Breen, Chaomei Chen, Xia Lin, Fernando U Garcia
A visual analytics system for breast tumor evaluation
2008 Oct;30(5):279-90
Abstract: To develop a system for the interactive exploration and examination of histologically derived data that is associated with breast tumors and may be used to evaluate the histologic grade of the tumor. - Tanja Heller, Ingelore Nagel, Bettina Ehrlich, Mathias Bähr, Herwig Strik
Automated cerebrospinal fluid cytology
Comparative Study: 2008 Jun;30(3):139-44
Abstract: To evaluate the Abbott CELL-DYN Sapphire cytometer for cerebrospinal fluid (CSF) cell count and differentiation. - Leopold G Koss
Atypical urothelial cells
Comment: 2008 Feb;30(1):61-2 - Hugo Galera-Ruiz, Ricardo Gonzalez-Campora, Manuel Rey-Barrera, Angel Rollón-Mayordomo, Antonio Garcia-Escudero, José M Fernández-Santos, Manuel DeMiguel, Hugo Galera-Davidson
W43X SDHD mutation in sporadic head and neck paraganglioma
2008 Apr;30(2):119-23
Abstract: To analyze the presence of SDHD gene mutations in patients with sporadic head and neck paraganglioma. - Peter H Bartels, Robert S Krouse, Anil R Prasad, Michael Yozwiak, Yun Liu, Hubert G Bartels, David S Alberts
Actinic damage in histopathologically normal skin
2008 Dec;30(6):316-22
Abstract: To establish measures of sun damage in histopathologically normal skin. - Liang Cheng, David G Bostwick
Overdiagnosis of bladder carcinoma
2008 Oct;30(5):261-4
Abstract: To describe a group of archival patients who were overdiagnosed with bladder cancer according to contemporary criteria. - Lars Egevad
Recent trends in gleason grading of prostate cancer. II. Prognosis, reproducibility and reporting
Review: 2008 Oct;30(5):254-60
Abstract: Gleason grading of prostate cancer is the most important histopathologic predictor of prognosis. In recent years, a number of changes have been made in how Gleason grading is performed and reported. - Shannon M Brankley, Elizabeth J Adams, Michael R Christensen, Cortney R Everts, Jennifer D Lund, Trynda N Oberg, Amy M Plagge, Angela H Zieman, Benjamin R Kipp, Kevin C Halling
A study of the reproducibility of a fluorescence in situ hybridization bladder cancer detection assay
Comparative Study: 2008 Jun;30(3):145-51
Abstract: To assess the reproducibility of the UroVysion fluorescence in situ hybridization (FISH) bladder cancer detection assay. - Lars Egevad
Recent trends in Gleason grading of prostate cancer: I. Pattern interpretation
Review: 2008 Aug;30(4):190-8
Abstract: Histologic grading remains the most useful tissue-based predictor of prognosis of prostate cancer. The Gleason system is now the only grading system recommended by the World Health Organization (WHO) for prostatic carcinoma. In recent years, there has been a gradual shift of how the Gleason grading is applied in practice. - Liang Cheng, Gregory T MacLennan, Fadi W Abdul-Karim, Antonio Lopez-Beltran, Rodolfo Montironi
Eosinophilic metaplasia of the prostate: a newly described lesion distinct from other eosinophilic changes in prostatic epithelium
2008 Aug;30(4):226-30
Abstract: To describe the morphologic, immunohistochemical and ultrastructural features of large, intensely eosinophilic cytoplasmic granules in prostatic epithelial cells in the benign prostate, as well as the prevalence of this condition. - Mariana R B Mello, Konradin Metze, Randall L Adam, Fernanda G Pereira, Micheline G Magalhães, Cíntia G F Machado, Irene Lorand-Metze
Phenotypic subtypes of acute lymphoblastic leukemia associated with different nuclear chromatin texture
2008 Apr;30(2):92-8
Abstract: To determine if phenotypic subtypes of acute lymphoblastic leukemia (ALL) are associated with different nuclear textures. - Xiaodong Teng, Xinru Yu, Guihua Wang, Linjie Xu, Maode Lai
Sclerosing angiomatoid nodular transformation of the spleen
2008 Jun;30(3):125-32
Abstract: To study clinical and pathologic features of sclerosing angiomatoid nodular transformation (SANT) and differential diagnosis, we reviewed splenectomy specimens from the Department of Pathology, First Affiliated Hospital, School of Medicine, Zhejiang University (January 1990 to December 2006) and another case from consultation at Second Jiaxing Municipal Hospital, Zhejiang Province, finding 7 cases of this lesion. - Lucia Tylková, Marta Novotová, Ivan Zahradník, Alexander Kiss
Evaluation of changes in secretory granules of atrial myocytes: a morphometric approach
2008 Feb;30(1):53-9
Abstract: To evaluate the sensitivity and applicability of stereologic analysis for estimating changes in the secretory granule content of atrial myocytes. - Maurizio Vertemati, Maria Goffredi, Claudia Moscheni, Silvio Callegari, Laura Vizzotto
Human visceral fat in different anthropometric patterns and in diabetes: a morphometric study
2008 Feb;30(1):39-46
Abstract: To evaluate the cellularity of the adipose tissue and the size of adipocytes in unrelated adults and investigate any correlation between morphometric and anthropometric or clinical variables. - Tian Huang, Maohuai Chen, Mingyao Wu, Xianying Wu
Image analysis of DNA content and nuclear morphometry for predicting radiosensitivity of nasopharyngeal carcinoma
2008 Jun;30(3):169-74
Abstract: To investigate the relationship among nuclear DNA content, nuclear morphology, clinical response, and radiosensitivity in nasopharyngeal carcinoma (NPC) and the suitability of image cytometric analysis of DNA content and nuclear morphology for predicting radiosensitivity of NPC prior to radiotherapy. - Radostin Simeonov, Galina Simeonova
Computer-assisted nuclear morphometry in relation to metastasis to regional lymph nodes in canine hepatoid adenocarcinomas
2008 Dec;30(6):343-6 - Mee Lee Looi, Ahmad Zailani Hatta Mohd Dali, Siti Aishah Md Ali, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof
Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix
2008 Apr;30(2):63-70
Abstract: To assess the expression of p53, bcl-2 and Ki-67 in the progression of cervical neoplasia. - Burkhard Helpap, Lars Egevad
Correlation of modified Gleason grading with pT stage of prostatic carcinoma after radical prostatectomy
2008 Feb;30(1):1-7
Abstract: To study the correlation between modified Gleason score (GS) and pT stage of radical prostatectomy (RP) specimens. - Norbert Röhrl, José R Iglesias-Rozas, Galia Weidl
A modern reproducible method for the histologic grading of astrocytomas with statistical classification tools
2008 Feb;30(1):33-8
Abstract: To investigate whether statistical classification tools can infer the correct World Health Organization (WHO) grade from standardized histologic features in astrocytomas and how these tools compare with GRADO-IGL, an earlier computer-assisted method. - Damjana Versa-Ostojić, Teodora Stanković, Snjezana Stemberger-Papić, Danijela Vrdoljak-Mozetic, Miljenko Manestar, Maja Krasević
Nuclear morphometry and AgNOR quantification: computerized image analysis on ovarian mucinous tumor imprints
2008 Jun;30(3):160-8
Abstract: To determine the morphometric characteristics of nuclei and silver-stained nucleolar organizer regions (AgNORs) on cytologic imprints and their value in differential cytodiagnosis of benign, atypical proliferative (borderline) and malignant ovarian mucinous tumors. - Engin Devecí
Role of allopurinol, verapamil, dexamethasone and trifluoperazine as prophylactic agents in intestinal ischemia-reperfusion
2008 Apr;30(2):99-104
Abstract: To study the effect of prophylactic agents allopurinol, verapamil, dexamethasone and trifluoperazine on ischemic intestinal damage. - Ibrahim Mansoor, Roger R Calam, Basim Al-Khafaji
Role of urinary NMP-22 combined with urine cytology in follow-up surveillance of recurring superficial bladder urothelial carcinoma
2008 Feb;30(1):25-32
Abstract: To determine efficacy and utility of NMP-22 in follow-up of bladder urothelial carcinoma (UC) and compare NMP-22 as a single evaluating test vs combination with cytology. - Maryam Kadivar, Mehrnoush Attar
Argyrophilic nucleolar organizer region counts in exfoliative cytology of buccal mucosa from opium addicts, smokers and nonsmokers
2008 Oct;30(5):274-8
Abstract: To compare the argyrophilic nucleolar organizer region (AgNOR) count of cells collected from the normal buccal mucosa of cigarette smokers, opium addicts and nonsmokers. - Ralf Hilfrich, Jalil Hariri
Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker
2008 Apr;30(2):78-82
Abstract: To proof the prognostic relevance of HPV L1 capsid protein detection on colposcopically-guided punch biopsies in combination with p16. - Christian Garbar, Corinne Mascaux, Eric Wespes
Expression of MUC1 and sialyl-Tn in benign prostatic glands, high-grade prostate intraepithelial neoplasia and malignant prostatic glands: a preliminary study
2008 Apr;30(2):71-7
Abstract: To postulate a possible role of MUC1 and sialylated mucins (sTn) in prostate malignancy. - Spiros Kostopoulos, Dionisis Cavouras, Antonis Daskalakis, George C Kagadis, Ioannis Kalatzis, Pantelis Georgiadis, Panagiota Ravazoula, George Nikiforidis
Cascade pattern recognition structure for improving quantitative assessment of estrogen receptor status in breast tissue carcinomas
2008 Aug;30(4):218-25
Abstract: To develop and validate a computer-based approach for the quantitative assessment of estrogen receptor (ER) status in breast tissue specimens for breast cancer management. - Martin Voss, Lutz Trojan, Annette Steidler, Christel Weiss, Rainer Grobholz, Peter Alken, Maurice Stephan Michel
Serum vascular endothelial growth factor C level in patients with prostate cancer and benign prostatic hyperplasia
2008 Aug;30(4):199-202
Abstract: To compare serum vascular endothelial growth factor C (VEGF-C) levels in patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and analyze VEGF-C levels in relation to clinicopathologic parameters. - Christian Bolenz, Lutz Trojan, Ute Gabriel, Patrick Honeck, Gunnar Wendt-Nordahl, Axel Schaaf, Peter Alken, Maurice Stephan Michel
Cellular uptake and ex vivo urothelial penetration by oligodeoxynucleotides for optimizing treatment of transitional cell carcinoma
2008 Oct;30(5):265-73
Abstract: To evaluate cellular uptake and urothelial penetration of oligodeoxynucleotides (ODNs) in transitional cell carcinoma (TCC) cell lines and in a porcine ex vivo model, respectively. - Patrícia Campos Fontes, Gustavo Henrique Marques Corrêa, Jaqueline Scholz Issa, Janete Dias Almeida
Quantitative analysis of AgNOR proteins in exfoliative cytology specimens of oral mucosa from smokers and nonsmokers
2008 Feb;30(1):16-24
Abstract: To determine the cell proliferation rate and possible effects of cigarette smoking on the oral mucosa lining through analysis of silver-stained nucleolar organizer regions (AgNORs) in exfoliative cytology specimens. - Andrea Brunner, Günther Schönhuber, Martin Waldner, Georg Schaefer, Gregor Mikuz, Irmgard Verdorfer
Chromosomal aberrations in urothelial carcinoma of the bladder and the World Health Organization 2004 grading system
2008 Oct;30(5):297-305
Abstract: To evaluate differences in chromosomal aberrations in recurrent urothelial cancer (UC) of the bladder between the World Health Organization (WHO) 1973 and 2004 classification a retrospective study was performed. - Vladimir Kirillov, Elena Stebenyaeva, Evgeny Demidchik
Comparative morphometric analysis of thyrocytes in a primary tumor and regional metastases in papillary thyroid gland cancer
Comparative Study: 2008 Aug;30(4):209-17
Abstract: To perform a comparative analysis of thyrocyte nuclei and the aggregability degree in tumor cells in the thyroid gland with papillary cancer and in cervical lymph nodes with metastases. - Luciane C Dreher Irion, João Carlos Prolla, Antônio A Hartmann, Klaus L Irion, Vinícius D Da Silva
Angiogenesis in non-small cell lung cancer: microvessel area in needle biopsy in vascular tumor density
2008 Apr;30(2):83-91
Abstract: To evaluate angiogenesis in non-small cell lung cancer (NSCLC) through immunohistochemistry with CD34 and computerized image analysis comparing the microvessel area in needle biopsies and surgical specimens. - Klaus Kayser, Sabah Amir Hoshang, Konradin Metze, Torsten Goldmann, Ekkehard Vollmer, Dominik Radziszowski, Zdravko Kosjerina, Masoud Mireskandari, Gian Kayser
Texture- and object-related automated information analysis in histological still images of various organs
2008 Dec;30(6):323-35
Abstract: To create algorithms and application tools that can support routine diagnoses of various organs. - Concepción Lara-Bohórquez, Ricardo González-Cámpora, Eladio Mendoza-García, Juan José Ríos-Martín, María Jesús Pareja-Megía, Antonio López-Beltrán
TP53, BCL-2, p21Waf1/Cip1 and metallothionein as markers of differentiation, response to treatment and prognosis in neuroblastic tumors
2008 Apr;30(2):105-12
Abstract: To identify markers of response to therapy in neuroblastic tumors. - Maria J Requena, Jose C Carrasco, Jose Alvarez-Kindelan
Role of molecular markers in diagnosis and prognosis of renal cell carcinoma
Comment: 2008 Dec;30(6):336-7 - Alessandra Filosa, Andrea Fabiani
Angiogenesis and molecular markers as specific therapeutic targets in renal cell carcinomas
2008 Jun;30(3):185-6 - Bernd Gromoll, Phil Salmon
Microcomputed tomography (micro-CT): a possibly useful technique in assessment of breast tumor specimens
2008 Feb;30(1):60-1 - Rafael Prieto, Juan C Regueiro, Manuel Leva
Utility of prostate biopsy morphometric sum optical density for identifying extraprostatic extension on subsequent prostatectomy
Comment: 2008 Dec;30(6):337-8 - Alessandra Filosa, Andrea Fabiani
Renal cell carcinoma: molecular and genetic markers as new prognostic and therapeutic tools
2008 Dec;30(6):341-3 - Raquel Mazzilli Toscano de Oliveira, Erica Negrini Lia, Renato Maia Guimarães, Anamélia Lorenzetti Bocca, Florêncio Figueiredo Cavalcante Neto, Tarcília Aparecida da Silva
Cytologic and cytometric analysis of oral mucosa in Alzheimer's disease
2008 Apr;30(2):113-8
Abstract: To analyze cytomorphologically the buccal mucosa of patients with Alzheimer's disease (AD). - Rodolfo Montironi, Richard Yardley Ball, David Francis Rees Griffiths, Kenneth Grigor, Patricia M Harnden, Michel Jarmulowicz, Lorna Jean McWilliam, Robert Peter Moseley, Margaret Constance Parkinson, Alfredo Santinelli, Sue Mary Moss, Jane Westfield Melia
Bayesian belief network for the Gleason patterns in prostatic adenocarcinoma: development of a diagnostic decision support system for educational purposes
2008 Feb;30(1):8-15
Abstract: To develop a Bayesian belief network (BBN) for Gleason grading of prostate adenocarcinoma. - Banu Lebe, Ugur Pabuççuoglu, Erdener Ozer
Expression pattern of type IV collagen in sporadic dysplastic melanocytic nevi
2008 Oct;30(5):291-6
Abstract: To investigate the expression and distribution pattern of type IV collagen in dysplastic nevi (DN) and to determine whether DN exhibits a morphologic difference from common melanocytic nevi (CMN) and cutaneous malignant melanomas (MM) and therefore can be classified as a separate entity. - Enrico Bollito, Carlo Terrone, Alessandro Volpe, Francesco Porpiglia, Cecilia Cracco, Massimiliano Poggio, Susanna Grande, Luisella Righi, Maurizio Bellina, Mauro Papotti, Roberto Mario Scarpa
Changes in prostate cancer at radical prostatectomy during the prostate specific antigen era: an Italian experience
2008 Jun;30(3):152-9
Abstract: To assess changes in prostate cancer clinical and pathologic features by review of 15 years' experience with radical prostatectomy. - Rajan Arora, Amany Abd El-Hameed, Mahmoud Sayed Ahmad
Fine needle aspiration cytology and immunocytochemistry of a case of mucinous carcinoma of the breast with neuroendocrine differentiation
Case Reports: 2008 Oct;30(5):306-8 - Roberta Mazzucchelli, Doriana Morichetti, Sara Giorgini, Francesca Barbisan
Classification and reclassification of adult renal epithelial tumors
2008 Aug;30(4):247-8 - Theodorus H Van der Kwast, Alexandre R Zlotta, Neil Fleshner, Michael Jewett, Antonio Lopez-Beltran, Roldolfo Montironi
Thirty-five years of noninvasive bladder carcinoma: a plea for the use of papillary intraurothelial neoplasia as new terminology
2008 Dec;30(6):309-15
Abstract: Since the introduction of the World Health Organization (WHO) 1973 terminology for bladder cancer, noninvasive epithelial bladder tumors have consistently been labeled bladder carcinomas. In the WHO 2004 classification the removal of the "carcinoma" label from a small subset of noninvasive bladder carcinomas with indolent behavior created the entity of papillary urothelial neoplasms of low malignant potential, but the remaining noninvasive carcinomas of the urothelial tract retained this label. - Takeshi Nagashima, Masahiro Sakakibara, Yukio Nakatani, Masaru Miyazaki
Preoperative cytologic morphometry may assist in predicting patient outcome after surgery in papillary thyroid cancer
2008 Aug;30(4):231-6
Abstract: To evaluate the quantitative estimations of various cytologic nuclear features on smears obtained by preoperative fine-needle aspiration and to examine their correlation with patient outcome after surgery for papillary thyroid cancer. - Doriana Morichetti, Sara Giorgini, Tiziana Pieramici, Francesca Barbisan, Roberta Mazzucchelli
Is it time for a new bladder neoplasms classification?
2008 Dec;30(6):338-40 - Ana Blanca, Alfredo Vidal-Jimenez, Pablo Campos
Histone acetylation and chromatin pattern in cancer: a review
Comment: 2008 Dec;30(6):340-1 - Evangelia Kararizou, Panagiota Manta, Nikolaos Kalfakis, Demetrios Vassilopoulos
Karyometric changes of intrafusal muscle fibers in neuromuscular diseases
2008 Dec;30(6):346-8 - Burkhard Helpap, Lars Egevad
Correlation of modified Gleason grading of prostate carcinoma with age, serum prostate specific antigen and tumor extent in needle biopsy specimens
2008 Jun;30(3):133-8
Abstract: To investigate the correlation of biopsy grade with age, serum prostate specific antigen (PSA) and biopsy tumor extent using the conventional and modified Gleason grading systems. - Rossella Di Trolio, Giuseppe Di Lorenzo, Alessandro Iacono, Alessandra Filosa, Mario Delfino, Francesco Paolo D'Armiento
Expression of HECA-452 antigen correlates with disease relapse in mycosis fungoides
2008 Aug;30(4):203-8
Abstract: To determine the expression of HECA-452 epitope in mycosis fungoides (MF), assess whether its expression increases in relapsed MF compared with nonrelapsed MF and determine the potential prognostic relevance of HECA-452 expression. - Randall L Adam, Neucimar J Leite, Konradin Metze
Image preprocessing improves Fourier-based texture analysis of nuclear chromatin
2008 Jun;30(3):175-84
Abstract: To investigate whether preprocessing of digitized images can improve the image analysis of chromatin of cytologic preparations using Fast Fourier Transformation (FFT). - Turkan Rezanko, Asli Kahraman Akkalp, Mine Tunakan, Aysegul Akder Sari
MIB-1 counting methods in meningiomas and agreement among pathologists
2008 Feb;30(1):47-52
Abstract: To evaluate the correlation of MIB-1 labeling index (LI) obtained by 2 counting methods with histologic grade and investigate interobserver variability between these methods.
