Volume 22 (2006) Issue 1 - Issue 6
- Terrence M Katona, Antonio Lopez-Beltran, Gregory T MacLennan, Lirong Cheng, Rodolfo Montironi, Liang Cheng
Soft tissue tumors of the penis: a review
Review: 2006 Aug;28(4):193-206
Abstract: Penile soft tissue tumors comprise 5% of tumors at this site and most have been reported as isolated case reports. The purpose of this review is to aid the practicing surgical pathologist in distinguishing penile soft tissue tumors, such as sarcomatoid squamous cell carcinoma, from other prognostically and therapeutically important entities in the differential diagnosis. - Kenneth A Iczkowski, Samantha L Butler
New immunohistochemical markers in testicular tumors
Review: 2006 Aug;28(4):181-7
Abstract: The annual incidence of testicular neoplasms has doubled in the last 40 years, with an estimated 7,500 new cases of germ cell tumor each year. The role of immunostaining has increased with the introduction of several novel markers in the last decade. - Hemamali Samaratunga, Robert A Gardiner, John Yaxley, Ian Brown
Atypical prostatic glandular proliferations on needle biopsy: Diagnostic implications, use of immunohistochemistry, and clinical significance
Review: 2006 Apr;28(2):104-10
Abstract: In recent times, PSA screening and a substantial increase in prostate needle biopsies have not only resulted in detection of minute foci of cancer but have also very likely resulted in increased detection of atypical glandular proliferations. Not uncommonly, there are only a limited number of atypical glands in these biopsies, and these require careful evaluation to enable an accurate diagnosis. - Darrell D Davidson, Liang Cheng
"Field cancerization" in the urothelium of the bladder
Editorial: 2006 Dec;28(6):337-8 - Antonio Lopez-Beltran, Gregory T MacLennan, Rodolfo Montironi
Cyclin E as molecular marker in the management of breast cancer: a review
Review: 2006 Apr;28(2):111-4
Abstract: Over the past decade numerous molecular markers have been identified that may play a role in breast carcinogenesis and prognosis. The most commonly used markers in clinical practice are the estrogen receptor, progesterone receptor and HER-2/neu. Recent studies found cyclin E to be a promising prognostic indicator in breast cancer and examined its potential as a target for therapy. - Brian P Adley, Ximing J Yang
Application of alpha-methylacyl coenzyme A racemase immunohistochemistry in the diagnosis of prostate cancer: a review
Review: 2006 Feb;28(1):1-13
Abstract: Alpha-methylacyl coenzyme A racemase (AMACR) is a recently discovered enzyme protein that has been shown to be increased at both the mRNA and protein levels in prostatic adenocarcinoma as compared with normal prostatic tissues. - M Teresa del Vecchio, M Carmela Epistolato, Sergio A Tripodi, Rodolfo Montironi, Antonio Giordano
Intratubular germ cell neoplasia of unclassified type
Review: 2006 Jun;28(3):157-70
Abstract: Intratubular germ cell neoplasia of unclassified type (IGCNU) is the precursor lesion of adult testicular germ cell invasive tumors. Primordial germ cells (PGCs) are recognized as the cells of origin of testicular germ cell tumors (TGCTs) because of the genetic and phenotypic characteristics analyzed. - Wei-Qiang Zheng, Rong Ma, Jian-Ming Zheng, Zhi-Jing Gong
Elastin distribution in the normal uterus, uterine leiomyomas, adenomyosis and adenomyomas: a comparison
Comparative Study: 2006 Apr;28(2):115-20
Abstract: To describe the histologic distribution of elastin in the nonpregnant human uterus, uterine leiomyomas, adenomyosis and adenomyomas. - Mario Scartozzi, Chiara Pierantoni, Rossana Berardi, Stefania Antognoli, Italo Bearzi, Stefano Cascinu
Epidermal growth factor receptor: a promising therapeutic target for colorectal cancer
Review: 2006 Apr;28(2):61-8
Abstract: The epidermal growth factor receptor is a 170,000-kd transmembrane glycoprotein involved in signaling pathways affecting cellular growth, differentiation, and proliferation. An abnormal expression of the epidermal growth factor receptor (EGFR) has been described in many human tumors and implicated in the development and prognosis of malignancies, thus representing not only a possible prognostic marker, but primarily a rational molecular target for a new class of anticancer agents. - Brian P Adley, Veronica Papavero, Jun Sugimura, Bin T Teh, Ximing J Yang
Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma
2006 Aug;28(4):228-36
Abstract: To investigate the diagnostic value of cytokeratin 7 (CK7) and parvalbumin at mRNA and protein levels. - Richard R Gammon, Marzieh Kharazi, John T Brandt, Sedigheh Keyhani-Rofagha
Correlation between the papanicolaou stain and the Wright-Giemsa stain in body fluids: a quality assurance study
Comparative Study: 2006 Jun;28(3):171-4
Abstract: To compare the use of Papanicolaou and Wright-Giemsa stains for the evaluation of body fluids in cytology and hematology laboratories and determine whether other factors account for discrepancies in diagnosis. - Michael A Model, James L
Intensity calibration of a laser scanning confocal microscope based on concentrated dyes
2006 Oct;28(5):253-61
Abstract: To find water-soluble fluorescent dyes with absorption in various regions of the spectrum and investigate their utility as standards for laser scanning confocal microscopy. - Mariam P Auada, Randall L Adam, Neucimar J Leite, Maria B Puzzi, Maria L Cintra, William B Rizzo, Konradin Metze
Texture analysis of the epidermis based on fast Fourier transformation in Sjögren-Larsson syndrome
Comparative Study: 2006 Aug;28(4):219-27
Abstract: To investigate whether image analysis of routine hematoxylin-eosin (H-E) skin sections using fast Fourier transformation (FFT) could detect structural alterations in patients with Sjögren-Larsson syndrome (SLS) diagnosed by molecular biology. - Gian Kayser, Dominik Radziszowski, Piotr Bzdyl, Rainer Sommer, Klaus Kayser
Theory and implementation of an electronic, automated measurement system for images obtained from immunohistochemically stained slides
2006 Feb;28(1):27-38
Abstract: To develop and implement an Internet-based, automated image measurement system for immunohistochemically stained slides including fluorescence images in online and off-line modes. - Binoj C Nair, Sai Kumar, Sudha Rani, Om Prakash Paliwal
Analysis of karyometric variables in spontaneously occurring canine mammary tumors
2006 Oct;28(5):292-6
Abstract: To study alteration in karyometric variables to distinguish benign from malignant canine mammary tumors. - Nilotpal Chowdhury, Muktha R Pai, Flora D Lobo, Hema Kini, Rebecca Varghese
Interobserver variation in breast cancer grading: a statistical modeling approach
2006 Aug;28(4):213-8
Abstract: To study random and the systematic error in breast cancer grading, to find the source of disagreements and measure the reliability of graders so that appropriate corrective action can be taken. - Archana Bargaje, Girish Venkataraman, Robert Flanigan, Eva M Wojcik, Vijayalakshmi Ananthanarayanan
Utility of prostate biopsy morphometric sum optical density for identifying extraprostatic extension on subsequent prostatectomy
2006 Dec;28(6):343-5 - Adriana Esther Rocher, Analía Gonzalez, Luis Alberto Palaoro, Ana María Blanco
Usefulness of AgNOR technique and CEA expression in atypical metaplastic cells from cervical smears
2006 Jun;28(3):130-6
Abstract: To evaluate the proliferating capacity of atypical metaplastic cells in cervical smears by AgNOR technique and image analysis and investigate the probable relation with squamous intraepithelial lesions (SIL) using immunocytochemical assay for carcinoembryonic antigen (CEA). - Reinhold Nafe, Bernard Yan, Wolfgang Schlote, Berthold Schneider
Application of different methods for nuclear shape analysis with special reference to the differentiation of brain tumors
Comparative Study: 2006 Apr;28(2):69-77
Abstract: To study the discriminatory power of different methods designed for nuclear shape analysis with reference to the differentiation and grading of brain tumors and the differentiation between proliferating and nonproliferating nuclei. - Başak Yalçin, Nilüfer Arda, Gaye Güler Tezel, Mustafa Erman, Nuran Alli
Expressions of vascular endothelial growth factor and CD34 in oral aphthous lesions of Behçet's disease
2006 Dec;28(6):303-6
Abstract: Behçet's disease (BD) is an immunoin-flammatory vasculitis with an unknown etiopathogenesis. Vascular endothelial growth factor (VEGF) is a cytokine-stimulating angiogenesis. It has been suggested to play a role in inflammation and pathogenesis of vasculitic processes. - Mathilde E Boon, Thomas H D Berger, Anneke J H F F Middag-Broekman, Lambrecht P Kok
Optimized quality of histologic images allows the use of neural network scanning in diagnosis of fungal infection of abnormal nails
Comparative Study: 2006 Apr;28(2):78-86
Abstract: The neural network scanning (NNS) system, formerly known as Papnet, is capable of selecting fungi in cervical smears. The objective of this study was to investigate whether the optimized quality of histologic images created using a combination of coagulant fixation and microwave histoprocessing allows the application of this computer-assisted microscopy in the diagnostic process. - Unsal Han, Aysegul Adabağ, Fulya Köybaşioğlu, Binnur U Onal
Clinical value of cell counts and indices in testicular fine needle aspiration cytology in primary infertility: diagnostic performance compared with histology
Clinical Trial: 2006 Dec;28(6):331-6
Abstract: To compare the diagnostic value of testicular fine needle aspiration (FNA) cytology with that of open biopsy in primary infertility and nonobstructive azospermia or severe oligozoospermia, to evaluate the reliability of percentage cell counts and cell indices. - Ming Zhou, Cristina Magi-Galluzzi, Jonathan I Epstein
Prostate basal cell lesions can be negative for basal cell keratins: a diagnostic pitfall
Case Reports: 2006 Jun;28(3):125-9
Abstract: Prostate basal cell lesions can have architectural and cytologic atypia that mimic prostate adenocarcinoma. Immunohistochemical stains for basal cell markers are most helpful in the differential diagnosis. All of the published studies show basal cell lesions are positive for basal cell keratins, whereas adenocarcinoma is negative for both. We reported two cases of prostate basal cell lesions with negative basal cell keratin expression by immunohistochemistry. - Matjaz Rode, Margareta Strojan Flezar, Mirela Kogoj-Rode, Marija Us-Krasovec
Image cytometric evaluation of nuclear texture features and DNA content of the reticular form of oral lichen planus
2006 Oct;28(5):262-8
Abstract: To analyze image cytometric chromatin changes reflected in nuclear texture features and DNA ploidy of oral lichen planus in relation to the normal buccal mucosa and buccal mucosa expressing malignancy-associated changes in cancer patients. - Roberta Mazzucchelli, Burçin Tuna
Noninvasive urothelial neoplasms: which classification?
2006 Dec;28(6):340 - Edmond Kahn, Anne Vejux, Franck Ménétrier, Christophe Maiza, Arlette Hammann, Anabelle Sequeira-Le Grand, Frédérique Frouin, Yves Tourneur, Frédéric Brau, Jean-Marc Riedinger, Eric Steinmetz, Andrew Todd-Pokropek, Gérard Lizard
Analysis of CD36 expression on human monocytic cells and atherosclerotic tissue sections with quantum dots: investigation by flow cytometry and spectral imaging microscopy
Comparative Study: 2006 Feb;28(1):14-26
Abstract: To demonstrate CD36 expression with quantum dots (QDs) 525 and/or 605 on human monocytic U937 cells and atherosclerotic tissue sections by means of flow cytometry (FCM) and/or confocal laser scanning microscopy (CLSM). - Edmond Kahn, Franck Ménétrier, Anne Vejux, Thomas Montange, Dominique Dumas, Jean-Marc Riedinger, Frédérique Frouin, Yves Tourneur, Frédéric Brau, Jean-François Stoltz, Gérard Lizard
Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells
2006 Dec;28(6):316-30
Abstract: To evaluate CD36 expression with quantum dots 605 (QDs 605) on untreated and 7-ketocholesterol (7KC)-treated monocytic U937 cells by flow cytometry (FCM) and confocal and multiphoton laser scanning microscopy (CLSM). - Joshua Nyagol, Aggrey Nyong'o, Bessie Byakika, Lucy Muchiri, Mario Cocco, M M de Santi, Donatella Spina, Cristiana Bellan, Stefano Lazzi, Ioannis Kostopoulos, Pietro Luzi, Lorenzo Leoncini
Routine assessment of hormonal receptor and her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer
2006 Apr;28(2):97-103
Abstract: To report the expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor (Her-2/neu) in 158 Kenyan women with breast cancer and correlation with other prognostic indicators in this high-risk group. This study stressed the importance of routine assessment of the steroid receptors and Her-2/neu as a mode of therapeutic selection of patients for antihormonal or targeting monoclonal antibody (Herceptin) therapy, directed at the juxtamembrane domain of Her-2/neu protein in the developing countries such as Kenya. - Peter H Bartels, James Ranger-Moore, David Alberts, Lisa Hess, Marina Scarpelli, Rodolfo Montironi
Carcinogenesis and the hypothesis of phylogenetic reversion
2006 Oct;28(5):243-52
Abstract: Chemoprevention must target early molecular events involved in malignant transformation. The sequence of events leading from a normally functioning interphase cell to an uncontrolled tumor cell is only partially understood, impeding systematic design of chemopreventive agents. The respective roles of mutagenic and epigenetic mechanisms have not been definitively established. - Jorge Tolivia, Ana Navarro, Eva del Valle, Cristina Perez, Cristina Ordoñez, Eva Martínez
Application of Photoshop and Scion Image analysis to quantification of signals in histochemistry, immunocytochemistry and hybridocytochemistry
2006 Feb;28(1):43-53
Abstract: To describe a simple method to achieve the differential selection and subsequent quantification of the strength signal using only one section. - Pio Zeppa, Gilda Marino, Maria Lepore, Giancarlo Troncone, Gelsy A Lupoli, Bernadette Biondi, Marco Picardi, Fabrizio Pane, Antonio Vetrani, Lucio Palombini
Flow cytometry phenotypization of thyroidal lymphoid infiltrate and functional status in Hashimoto's thyroiditis
2006 Jun;28(3):148-56
Abstract: To evaluate the thyroidal lymphoid infiltrate (TLI) in thyroidal functional status (TFS) for differences among patients with Hashimoto's thyroiditis (HT). - Izabella Klimek, Andrzej Kaluzynski, Andrzej Kulig, Wieslaw Szymczak, Robert Ambroziak
Glomerular basement membrane thinning in children: a morphometric assessment
2006 Oct;28(5):269-80
Abstract: To develop our own procedures, allowing for a quick evaluation of glomerular basement membrane (GBM) thickness and to present a statistical classification of thin basement membrane disease (TBMD), minimal change disease (MCD), and IgA nephropathy (IgAN) cases. - Italo Bearzi, Alessandra Mandolesi, Federica Arduini, Antonello Costagliola, Renzo Ranaldi
Gastrointestinal stromal tumor. A study of 158 cases: clinicopathological features and prognostic factors
2006 Jun;28(3):137-47
Abstract: To increase knowledge on the behavior of gastrointestinal stromal tumors (GISTs) and factors influencing therapy. - Brian K Petroff, Teresa A Phillips, Bruce F Kimler, Carol J Fabian
Detection of biomarker gene expression by real-time polymerase chain reaction using amplified ribonucleic acids from formalin-fixed random periareolar fine needle aspirates of human breast tissue
2006 Oct;28(5):297-302
Abstract: To address the detection of breast cancer biomarker gene expression in formalin-fixed random periareolar fine needle aspiration (RPFNA) samples of benign breast tissue collected during breast cancer prevention trials by quantitative real-time polymerase chain reaction (qPCR). - Jeanne Adiwinata Pawitan, Isnani Azizah Suryono
Sensitivity and specificity of the micronucleus test in hypotonic-swollen mononuclear leukocytes compared to the micronucleus test in binucleated lymphocytes to assess chromosomal breaks
Comparative Study: 2006 Jun;28(3):175-80
Abstract: To examine the sensitivity and specificity of the micronucleus (MN) test on swollen mononuclear cells compared to that in binucleated lymphocytes. - Louis-Jacques van Bogaert
Sampling of sentinel nodes: a simulation study
Comment: 2006 Dec;28(6):345-6 - Michael A Model, James L Blank
Difference between mean and threshold as a measure of intensity in confocal microscopy images
2006 Dec;28(6):341-3 - Roberto Souza Camargo, Neuza Kasumi Shirata, Celso di Loreto, Eduardo Anselmo Garcia, Adauto Castelo, Adhemar Longatto Filho
Significance of AgNOR measurement in thyroid lesions
2006 Aug;28(4):188-92
Abstract: To evaluate the discriminating potential of AgNOR area measurement and count in thyroid tumors using static cytometry equipment. - Lauren Nieuwenhuizen, Mohd K Khalil, Naik Venkatesh, Nor Hayati Othman
Endometrial and endocervical secretion: the search for histochemical differentiation
Comparative Study: 2006 Apr;28(2):87-96
Abstract: To determine the ideal histochemical stain to differentiate between non-neoplastic and neoplastic endocervix and endometrium. - Alfredo Vidal-Jimenez
Gleason grading of prostate cancer in needle biopsies vs. radical prostatectomy specimens
Comment: 2006 Dec;28(6):340-1 - Zsolt Razga, Jens Randel Nyengaard
A stereologic approach to estimate the number of immunogold-labeled molecules in cells of tubules
2006 Feb;28(1):54-60
Abstract: The quantity of molecules can be measured very precisely by molecular biological methods, but the capabilities of these are limited to measure only the total mass of tissue. For estimating the number of molecules at the cell level, it is necessary to combine an immunohistochemical protocol with designed-based principles of stereology at the level of electron microscopy (EM). - Hai-Shan Wu, Sacha P Salzberg, Joan Gil
Automatic image segmentation with linear clustering for quantification of neointimal formation after surgical vein grafting
2006 Dec;28(6):307-15
Abstract: To identify extracellular matrix deposition on combined Masson elastin stains from cross-sectional, fixed vein grafts. - Takaharu Matsuda, Makoto Fujime, Koichi Suda
Relationship between the prostatic tissue components and natural history of benign prostatic hyperplasia
2006 Jun;28(3):121-4
Abstract: Few reports have been published on the relationship between prostatic tissue components and the natural history of benign prostatic hyperplasia (BPH). The present study was undertaken to evaluate this relationship. - Murat Demiriz, Zafer Kurumlu, Bülent Celasun, Omer Günhan
A simple method for the evaluation of epidermal thickness variations in psoriasis vulgaris
Comparative Study: 2006 Aug;28(4):237-42
Abstract: To evaluate the "variation" of the epidermal thickness and variables such as the mean, maximum, and minimum thickness for the diagnosis and follow-up of some skin diseases such as psoriasis. - Hüseyin Aktug, Serap Uslu, Mustafa Coşan Terek, Hasan Terzi, Mehmet Turgut, Serdar Ozşener, Onur Bilgin
Effects of ovariectomy and tamoxifen on rat bone tissue: histomorphometric and histopathologic study
Comparative Study: 2006 Aug;28(4):207-12
Abstract: To investigate possible detrimental effects on bone tissue induced by ovariectomy and tamoxifen (TMX) using bone densitometry and histomorphologic analysis. - Tomasz Markiewicz, Stanislaw Osowski, Janusz Patera, Wojciech Kozlowski
Image processing for accurate cell recognition and count on histologic slides
2006 Oct;28(5):281-91
Abstract: To design an automatic system for recognition and count of two different cell families on histologic slides. - Terrence M Katona, Alan J Shienbaum, Larry L Wyatt, Gordon A Brown, Liang Cheng
Malignant fibrous histiocytoma of the glans penis: a case report
Case Reports: 2006 Feb;28(1):39-42
Abstract: Malignant fibrous histiocytoma has been regarded as the most common sarcoma of older adults. However, recent opinion regards pleomorphic malignant fibrous histiocytoma as an undifferentiated high grade pleomorphic sarcoma not otherwise classifiable utilizing current techniques available in surgical pathology.