Volume 21 (2005) Issue 1 - Issue 6
- Roberta Mazzucchelli, Francesca Barbisan, Lucia M Tarquini, Alessandra Filosa, Nicoletta Campanini, Andrea B Galosi
Gleason grading of prostate carcinoma in needle biopsies vs. radical prostatectomy specimens
Review: 2005 Jun;27(3):125-33
Abstract: The Gleason grading system for prostatic carcinoma is the dominant method used around the world in research and in daily practice. It is based on glandular architecture. The grading system should be applied to all prostatic tissue samples, including needle core biopsies and radical prostatectomy specimens. Its prognostic value was tested in a large population with long-term follow-up that included use of survival as an endpoint. - Helena Lexander, Carina Palmberg, Gert Auer, Magnus Hellström, Bo Franzén, Hans Jörnvall, Lars Egevad
Proteomic analysis of protein expression in prostate cancer
2005 Oct;27(5):263-72
Abstract: To investigate protein expression in prostate cancer using 2-dimensional gel electrophoresis (2-DE) and mass spectrometry. - Harry B Burke, David G Bostwick, Isabelle Meiers, Rodolfo Montironi
Prostate cancer outcome: epidemiology and biostatistics
Review: 2005 Aug;27(4):211-7
Abstract: Substantial gaps exist in our ability to accurately predict prognosis, and these gaps limit our understanding of the complex mechanisms that contribute to the greatest cancer epidemic of our time, prostate cancer. This review addresses contemporary epidemiologic and biostatistical issues in prostate cancer. - Robert E Emerson, Liang Cheng
Immunohistochemical markers in the evaluation of tumors of the urinary bladder: a review
Review: 2005 Dec;27(6):301-16
Abstract: The clinical utility of immunohistochemistry in the diagnosis of tumors of the urinary bladder is well established. With recent advances in molecular biology and novel technologies, several biomarkers have emerged as important adjuncts in the diagnosis of lesions of the bladder. - Francesca Sanseverino, Giuseppina D'Andrilli, Felice Petraglia, Antonio Giordano
Molecular pathology of ovarian cancer
Review: 2005 Jun;27(3):121-4
Abstract: Ovarian cancer is the leading cause of death among women with gynecologic malignancies. Epithelial tumors typically constitute 80-90% of ovarian malignancies and are classified primarily as serous, mucinous, endometrioid, or clear cell. Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations. We describe such genetic alterations with specific reference to histologic subtypes. - Zehra Durmus, Esin Canel, Esma Kiliç
Spectrofluorimetric assay of ciprofloxacin hydrochloride in tablets
2005 Jun;27(3):162-6
Abstract: To describe the spectrofluorimetric method for the determination of ciprofloxacin hydrochloride in tablets under optimum conditions. - Roberta Mazzucchelli, Francesca Barbisan, Lucia M Tarquini, Marco Streccioni, Andrea B Galosi
Urothelial changes induced by therapeutic procedures for bladder cancer. A review
Review: 2005 Feb;27(1):27-34
Abstract: Topical and systemic therapeutic agents and treatment modalities, such as thiotepa and mitomycin C, cyclophosphamide, bacillus Calmette-Guérin, radiation therapy, photodynamic and laser therapy, and gene therapy, produce a host of changes in the bladder, some of them mimicking cancer. Pathologists must be aware that following these types of treatment, the clinical utility of urinary cytology is reduced. - Herwig Strik, Hilmar Luthe, Ingelore Nagel, Bettina Ehrlich, Mathias Bahr
Automated cerebrospinal fluid cytology: limitations and reasonable applications
Comparative Study: 2005 Jun;27(3):167-73
Abstract: To evaluate the precision and clinical applicability of the Bayer ADVIA 120 cytometer (Bayer Healthcare, Fernwald, Germany) for cerebrospinal fluid (CSF) cell count and differentiation. - Hyun-Ju Choi, Ik-Hwan Choi, Nam-Hoon Cho, Heung-Kook Choi
Color image analysis for quantifying renal tumor angiogenesis
2005 Feb;27(1):43-51
Abstract: To segment and quantify microvessels in renal tumor angiogenesis based on a color image analysis method and to improve the accuracy and reproducibility of quantifying microvessel density. - Reena Das, Jasreman Hayer, Pranab Dey, Gurjeewan Garewal
Comparative study of myelodysplastic syndromes and normal bone marrow biopsies with conventional staining and immunocytochemistry
Comparative Study: 2005 Jun;27(3):152-6
Abstract: To study the histomorphometric features of megakaryocytic elements in bone marrow trephine biopsies of various subtypes of myelodysplastic syndrome (MDS). - James Ranger-Moore, Denise Frank, Peter Lance, David Alberts, Michael Yozwiak, Hubert G Bartels, Janine Einspahr, Peter H Bartels
Karyometry in rectal mucosa of patients with previous colorectal adenomas
Clinical Trial: 2005 Jun;27(3):134-42
Abstract: To determine whether karyometric measurements taken in biopsies from histologically normal-appearing rectal mucosa could serve as a biomarker for the risk of recurrence of polyps. - Hyun-Ju Choi, Ik-Hwan Choi, Tae-Yun Kim, Nam-Hoon Cho, Heung-Kook Choi
Three-dimensional visualization and quantitative analysis of cervical cell nuclei with confocal laser scanning microscopy
2005 Jun;27(3):174-80
Abstract: To develop a method for the acquisition and processing of 3-dimensional images based on confocal laser scanning microscopy for the purpose of 3-dimensional visualization and quantitative analysis of cell nuclei. - Evangelia Kararizou, Panagiota Manta, Nikolaos Kalfakis, Dimitrios Vassilopoulos
Morphometric study of the human muscle spindle
2005 Feb;27(1):1-4
Abstract: To study the morphometric characteristics of the human muscle spindle in normal muscle and to investigate the influence of aging. - Pranab Dey
Basic principles and applications of fractal geometry in pathology: a review
Meta-Analysis: 2005 Oct;27(5):284-90
Abstract: The basic principles and prospects of fractal geometry in pathology are promising. All articles found with a PubMed search with the keywords fractal dimension (FD) and related to pathology were reviewed. All fractal objects have FDs, commonly calculated with box counting. - Aspasia Kyroudi-Voulgari, Mirsini Kouloukoussa, Christos Simigiatos, Petros Karakitsos, Anastasios Zervas, Christos Kittas, Dionisios Mitropoulos
DNA ploidy and immunomarking of bladder urothelial tumors before and after intravesical bacillus Calmette-Guérin treatment
Comparative Study: 2005 Feb;27(1):52-60
Abstract: To investigate DNA ploidy and immunoexpression of Ki-67 and p53 as predictive factors in cases of superficial urothelial cell carcinoma (UCC) treated with bacillus Calmette-Guérin (BCG). - Benjamin R Kipp, Emily G Barr Fritcher, Kristina M del Rosario, Carol L Stevens, Thomas J Sebo, Kevin C Halling
A systematic approach to identifying urothelial cells likely to be polysomic by fluorescence in situ hybridization
2005 Dec;27(6):317-22
Abstract: To determine which nuclear morphologic and background features are most associated with normal and abnormal chromosome patterns in urothelial cells evaluated by fluorescence in situ hybridization (FISH) with Vysis UroVysion (Downers Grove, Illinois, USA). - Enrico R Bollito, Donatella Pacchioni, Antonio Lopez-Beltran, Marco Volante, Carlo Terrone, Giovanni Casetta, Mauro Mari, Roberta DePompa, Susanna Cappia, Mauro Papotti
Immunohistochemical study of neuroendocrine differentiation in primary glandular lesions and tumors of the urinary bladder
Comparative Study: 2005 Aug;27(4):218-24
Abstract: Neuroendocrine (NE) cells are uncommon in primary adenocarcinoma (AC) and other glandular lesions of the bladder, with no recent study series concerning its significance in differential diagnosis, prognosis, or biologic significance. - Silvia Uccella, Maria Grazia Tibiletti, Barbara Bernasconi, Giovanna Finzi, Rita Oldrini, Carlo Capella
Aneuploidy, centrosome alteration and securin overexpression as features of pituitary somatotroph and lactotroph adenomas
Comparative Study: 2005 Oct;27(5):241-52
Abstract: To verify the presence of numerical chromosomal aberrations (NCAs) in different types of pituitary adenomas (PAs) and to investigate two of the mechanisms that are possibly related to aneuploidy in PAs: securin overexpression and centrosome alterations. - Lester J Layfield, Carlynn Willmore-Payne, Hiroyuki Shimada, Joseph A Holden
Assessment of NMYC amplification: a comparison of FISH, quantitative PCR multiplexing and traditional blotting methods used with formalin-fixed, paraffin-embedded neuroblastomas
Comparative Study: 2005 Feb;27(1):5-14
Abstract: To determine the degree of agreement between fluorescence in situ hybridization (FISH), Southern blot analysis, and LightCycler multiplex polymerase chain reaction (PCR) analysis in the assessment of NMYC gene amplification status in neuroblastoma. - Ayhan Ozcan, Mehmet Salih Deveci, Emin Oztas, Murat Dede, Muftit Cemal Yenen, Emin Turkay Korgun, Omer Gunhan
Prognostic value of GLUT-1 expression in ovarian surface epithelial tumors: a morphometric study
2005 Oct;27(5):277-83
Abstract: To investigate the reported increase in the expression of the glucose transporter GLUT-1 in borderline and malignant ovarian epithelial tumors and its relationship to prognosis. - Barbara Gazic, Joze Pizem, Marija Us-Krasovec
Dilution effect of nontumor cells on flow cytometric DNA S-phase fraction in breast cancer fine needle aspirates
2005 Oct;27(5):273-6
Abstract: To analyze the proportion of nontumor cells in fine needle aspirates of breast carcinoma and its influence on flow cytometric S-phase fraction (SPF) estimation. - Denise H Frank, John R Davis, James Ranger-Moore, Yun Liu, Hubert G Bartels, David S Alberts, Peter H Bartels
Karyometry of infiltrating breast lesions
2005 Oct;27(5):195-201
Abstract: To characterize nuclei from well-differentiated, moderately differentiated, and poorly differentiated lesions of invasive breast cancer by karyometry and to test the hypothesis that these diagnostic categories form homogeneous sets. - Raje Nijhawan, Arvind Rajwanshi
Cytomorphologic and morphometric limitations of the assessment of atypia in fibroadenoma of the breast
2005 Oct;27(5):273-6
Abstract: To investigate the relevance of nuclear morphometry in separating the categories of "fibroadenoma" and "fibroadenoma with atypia." - Petros Karakitsos, Abraham Pouliakis, George Kordalis, John Georgoulakis, Christos Kittas, Aspasia Kyroudes
Potential of radial basis function neural networks in discriminating benign from malignant lesions of the lower urinary tract
2005 Feb;27(1):35-42
Abstract: To investigate the potential value of morphometry and neural network tools for discriminating benign from malignant nuclei and lesions of the lower urinary tract. - Jian Guo, Yonghong Chen, Kaiya Zhou, Jingyan Li
Distribution of rDNA in the nucleus of Giardia lamblia: detection by Ag-I silver stain
2005 Feb;27(1):15-26
Abstract: To determine whether rDNA of Giardia lamblia forms a nucleolus organizer region (NOR)-like structure and is in a very primitive state. - Peter H Bartels, James Ranger-Moore, Hubert G Bartels, David S Alberts
Second order discriminant analysis in chemopreventive efficacy measurement
2005 Feb;27(1):15-26
Abstract: To describe the use of second order discriminant analysis as a classification methodology along with the underlying assumptions and sampling requirements, with special emphasis on the use of this analysis in chemopreventive efficacy studies. - Ji Shin Lee, Yoo Duk Choi, Chan Choi, Min Cheol Lee, Chang Soo Park, Kyung Whan Min
Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth
Comparative Study: 2005 Aug;27(4):232-40
Abstract: To evaluate the expression of tumor suppressor gene phosphatase and tensin homologue on chromosome 10 (PTEN) in ovarian epithelial tumors and its correlation with tumor growth and clinicopathologic features in ovarian adenocarcinomas. - Rasha Abu Eid, Gabriel Landini
Morphometry of pseudoepitheliomatous hyperplasia: objective comparison to normal and dysplastic oral mucosae
Comparative Study: 2005 Aug;27(4):232-40
Abstract: To compare the architectural and morphometric features of pseudoepitheliomatous hyperplasia (PEH) associated with oral granular cell tumors (GCT), normal oral mucosa, and oral epithelial dysplasia. - Dilip K Das, Prem N Sharma
Intranuclear cytoplasmic inclusions and nuclear grooves in fine needle aspiration smears of papillary thyroid carcinoma and its variants: advantage of the count under an oil-immersion objective over a high-power objective
2005 Apr;27(2):83-94
Abstract: To determine the advantage of examining fine needle aspiration (FNA) smears of papillary thyroid carcinoma (PTC) under a 100-x oil-immersion objective, which is capable of optically sectioning the cells. - Prashant Sharma, Neeta Kumar, Anil Kumar Bahadur, Deepak Kumar Shukla
Quantitative analysis of radiation-associated cellular changes in oral cancer and their correlations with histologic grade and clinical stage: a multivariate evaluation of 43 patients
Clinical Trial: 2005 Apr;27(2):111-7
Abstract: To quantitate radiation-associated cytologic abnormalities in oral cancer cells and analyze their relationships with radiation dose, clinical stage, and histologic grade. - Carolina Panis, Marta Souza
Methods of measuring volume changes in erythrocytes under hypoosmotic stress: a comparison
Comparative Study: 2005 Apr;27(2):95-100
Abstract: To compare methods of analyzing changes in red blood cell volume when exposed to osmotic challenge. - Marija Us-Krasovec, Janez Erzen, Mario Zganec, Margareta Strojan-Flezar, Jaka Lavrencak, David Garner, Alexei Doudkine, Branko Palcic
Malignancy associated changes in epithelial cells of buccal mucosa: a potential cancer detection test
2005 Oct;27(5):254-62
Abstract: To analyze the presence of malignancy associated changes (MACs) in normal buccal mucosa cells of lung and breast cancer patients and their relationship to tumor subtype, stage, and size. - Sheryl R Tripp, Carlynn Willmore-Payne, Lester J Layfield
Relationship between EGFR overexpression and gene amplification status in central nervous system gliomas
2005 Apr;27(2):71-8
Abstract: To correlate epidermal growth factor receptor (EGFR) protein overexpression, as assessed by immunohistochemistry, with EGFR gene amplification determined by fluorescence in situ hybridization in a series of gliomas. - Roberta Mazzucchelli, Francesca Barbisan, Daniela Stramazzotti, Rodolfo Montironi, Antonio Lopez-Beltran, Marina Scarpelli
Chromosomal abnormalities in macroscopically normal urothelium in patients with bladder pT1 and pT2a urothelial carcinoma: a fluorescence in situ hybridization study and correlation with histologic features
Comparative Study: 2005 Jun;27(3):143-51
Abstract: To analyze chromosomal abnormalities in macroscopically normal urothelium in patients with bladder pT1 and pT2a urothelial carcinoma and correlate the changes with histologic features. - Jata S Misra, Vinita Das, Anand N Srivastava, Uma Singh, Madhulika Singh
AgNOR counts in cervical smears under normal and other cytopathologic conditions
Comparative Study: 2005 Dec;27(6):337-40
Abstract: To investigate the diagnostic value of AgNOR counts in cervical smears in the process of cervical carcinogenesis and in discriminating the different grades of squamous intraepithelial lesion (SIL). - Vladimir A Kirillov, Elena E Stebeneva, Andrey A Paplevka, Evgeny P Demidchik
Quantitative changes in thyroid lymphoid cells as a marker of malignancy
2005 Apr;27(2):101-10
Abstract: To investigate the possibility of using morphometric changes in lymphoid cells in thyroid tissue as a marker of malignant tumors. - Hai-Shan Wu, Ruliang Xu, Noam Harpaz, David Burstein, Joan Gil
Segmentation of microscopic images of small intestinal glands with directional 2-D filters
2005 Oct;27(5):291-300
Abstract: We present an image segmentation algorithm for small intestinal glands consisting of goblet cells that are evenly distributed and arranged in parallel at the base. Making use of the properties of the chain distribution of the goblet cells, directional 2-dimensional (2-D) linear filters with different orientations were designed to enhance the rims of the intestinal glands. - Mahmoud R Hussein, Mohammad M A Bedaiwy, Alaa Ezat, Abdul Fatah Ibraheem, Mahmoud Nayel
Role of fine needle aspiration cytology (FNAC) and touch imprint cytology (TIC) in the evaluation of azoospermia
2005 Apr;27(2):67-70
Abstract: To assess the utility of fine needle aspiration cytology (FNAC) and touch imprint cytology (TIC) in the evaluation of azoospermia. - Pio Zeppa, Maria Lepore, Lucio Palombinis
Morphometric evaluation of thyrostatic treatment on thyrocytes in nodular goiter on cytologic samples
Comment: 2005 Apr;27(2):118-9
Abstract: To evaluate the morphometric changes in thyrocytes in nodular goiter after thyrostatic treatment using cytologic samples. - Nara de Mattos Granja, Sara Alexandrina Vinhas Ricardo, Adhemar Longatto Filho, Venancio Avancini Ferreira Alves, Carlos W M Bedrossian, Elizabeth L Wiley, Fernando C Schmitt
Potential use of loss of heterozygosity in pleural effusions of breast cancer metastases using the microsatellite marker of the 16q22.1 region of the CDH1 gene
2005 Apr;27(2):61-6
Abstract: To evaluate the presence of allelic loss in 16q22.1, including the locus of E-cadherin, in pleural effusions in breast cancer patients. - Peter H Bartels, Michael Descour, David S Alberts, James Ranger-Moore
The evolution of scanning microphotometry: a historical review
2005 Dec;27(6):323-36
Abstract: This article traces the evolution of scanning microphotometry from its beginning, with an emphasis on the developing technologies that have made feasible the rapid and detailed capture of high-resolution image information. Consideration is given to future directions that may prove fruitful to clinical practice. - Bülent Celasun, Erkan U Mumcuoğlu, Habil Kalkan
Sampling of sentinel lymph nodes: a simulation study
2005 Aug;27(4):225-31
Abstract: To analyze the effects of various slicing schemes on the detection of metastases in lymph nodes. - Francisco J Sánchez-Márin
A simple procedure for simulating samples of tissue using Voronoi diagrams
2005 Aug;27(4):225-31
Abstract: To describe a simple and quick procedure for modeling samples of tissue with Voronoi diagrams. - Roberto Souza Camargo, Marina Yoshie Sakamoto Maeda, Celso di Loreto, Neuza Kasumi Shirata, Eduardo Anselmo Garcia, Adhemar Longatto Filho
Is AgNOR and DNA ploidy analysis useful for evaluating thyroid neoplasms?
Comparative Study: 2005 Jun;27(3):157-61
Abstract: To correlate the subjective AgNOR counting method and DNA content with histologic diagnoses of thyroid cancer and invasion.