Volume 14 (1998) Issue 1 - Issue 6 | Analytical and quantitative cytology and histology

Volume 14 (1998) Issue 1 - Issue 6

C Magi-Galluzzi, M Murphy, M G Cangi, M Loda
Proliferation, apoptosis and cell cycle regulation in prostatic carcinogenesis
Review: 1998 Oct;20(5):343-50
Abstract: Cancer progression occurs because of imbalance in the processes of proliferation, differentiation and programmed cell death. In prostate cells, these processes are regulated at least in part by androgens. Structural alterations occur in a variety of genes regulating such processes.
P W Hamilton, P H Bartels, R Montironi, N H Anderson, D Thompson, J Diamond, S Trewin, H Bharucha
Automated histometry in quantitative prostate pathology
Review: 1998 Oct;20(5):443-60
Abstract: To review progress on the development of machine vision and image understanding in prostate tissue histology and to discuss the problems and opportunities afforded to pathology through the use of these techniques.
H Bonkhoff
Analytical molecular pathology of epithelial-stromal interactions in the normal and neoplastic prostate
Review: 1998 Oct;20(5):437-42
Abstract: To review recent data on epithelial-stromal interactions, recognized as playing an important role in prostatic growth in vitro.
A Moragas, M García-Bonafé, M Sans, N Torán, P Huguet, C Martín-Plata
Image analysis of dermal collagen changes during skin aging
1998 Dec;20(6):493-9
Abstract: To determine progressive quantitative, directional and textural changes in dermal collagen as a function of age and sex and to estimate their evolutive trend with appropriate regression models.
D G Bostwick
Practical clinical application of predictive factors in prostate cancer. A review with an emphasis on quantitative methods in tissue specimens
Review: 1998 Oct;20(5):323-42
Abstract: Predictive factors stratify cancer patients into homogeneous groups for treatment. There is an acute need for accurate predictive factors in patients with prostate cancer given the marked variation in treatment recommendations.
W A Sakr, D J Grignon
Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia. Relationship to pathologic parameters, volume and spatial distribution of carcinoma of the prostate
Review: 1998 Oct;20(5):417-23
Abstract: To summarize studies that have investigated the morphologic, spatial and volumetric relationship between prostate cancer and its putative precursors, high grade prostatic intraepithelial neoplasia (HGPIN) and atypical adenomatous hyperplasia (AAH).
Qian, R B Jenkins, D G Bostwick
Determination of gene and chromosome dosage in prostatic intraepithelial neoplasia and carcinoma
Review: 1998 Oct;20(5):373-80
Abstract: To review the utility of fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR) and comparative genomic hybridization (CGH) in the determination of gene and chromosome dosage in cancer specimens and to discuss the genetic association between prostatic intraepithelial neoplasia (PIN) and adenocarcinoma as detected by these three techniques.
S Gupta, P Sodhani
Sialadenosis of parotid gland: a cytomorphologic and morphometric study of four cases
Review: 1998 Jun;20(3):225-8
Abstract: Sialadenosis is recurrent, noninflammatory, nonneoplastic enlargement of salivary glands usually associated with an underlying systemic disorder.
J Brugghe, J P Baak, G A Meijer, P J van Diest, M Brinkhuis
Rapid and reliable assessment of volume percentage of epithelium in borderline and invasive ovarian tumors
1998 Feb;20(1):14-20
Abstract: To analyze factors determining intraobserver and interobserver reproducibility of stereology in borderline and invasive ovarian tumors.
P Yeaton, H F Frierson Jr, A Hittelet, C Duckworth, C DePrez, N Bourgeois, I Salmon, R S Jones, R Kiss, C Decaestecker
Use of image cytometry to classify biliary and ampullary adenocarcinomas
1998 Dec;20(6):509-16
Abstract: To create an objective classification system to perform TNM classification of ampullary adenocarcinoma and cholangiocarcinoma using image cytometric data derived from Feulgen-stained tumor nuclei.
B Zhou, U Jütting, K Rodenacker, P Gais, P Z Lin
Discrimination of esophageal dysplasia with progression and nonprogression. High-resolution image analysis for surrogate end point biomarkers
1998 Dec;20(6):500-8
Abstract: To detect textural nuclear features correlated with nonprogression and progression in esophageal dysplasia.
J Farley, D Loup, M Nelson, M J Miller, R Taylor, K Gray
Transferrin in normal and neoplastic endocervical tissues: distribution and receptor expression
1998 Aug;20(4):238-49
Abstract: Our recent studies showed that lactoferrin seems to be down-regulated in endocervical adenocarcinomas. We extended those studies to examine the expression of transferrin (Tf) and its receptor (TfR) in endocervical carcinogenesis and any relationship to the expression of lactoferrin, steroid receptors and the proliferative index.
P D Bozzo, L C Vaught, D S Alberts, D Thompson, P H Bartels
Nuclear morphometry in solar keratosis
1998 Feb;20(1):21-8
Abstract: To carry out a feasibility study for the development of procedures for the objective characterization and grading of solar keratotic skin lesions.
E Donois, V del Marmol, A Taïeb, G Ghanem, J E Surlève-Bazeille
Quantification of eumelanin and pheomelanin: stereologic image analysis method
Comparative Study: 1998 Aug;20(4):275-87
Abstract: To develop an ultrastructural stereologic image analysis method allowing quantification of intracellular melanization.
Y Sakamoto, E Taniguchi, K Kakudo
Objective evaluation of Papanicolaou staining
1998 Aug;20(4):250-6
Abstract: To evaluate the color of cytoplasm stained by Papanicolaou staining quantitatively.
W Q Zheng, R Z Zhan
Quantitative comparison of apoptosis to cell proliferation and p53 protein in breast carcinomas
1998 Feb;20(1):1-6
Abstract: To clarify the correlation between apoptosis and tumor cell proliferative activity in human breast cancer and to investigate their relevance to p53 protein.
H Motherby, B Nadjari, T Remmerbach, T Marcy, N Pomjanskaja, W Müller, K Knops, D Häussinger, B E Strauer, A Böcking
Static DNA cytometry as a diagnostic aid in effusion cytology: II. DNA aneuploidy for identification of neoplastic cells in equivocal effusions
1998 Jun;20(3):162-8
Abstract: The sensitivity of conventional cytology for identification of neoplastic cells in effusions is unsatisfactory, about 58%. The rate of diagnostically equivocal effusions in routine cytology is about 6%. DNA aneuploidy has previously been proven to be a sensitive and specific marker for the identification of tumor cells in effusions. In the present study we determined if malignancy can be identified in cytologically equivocal cells in effusions using DNA aneuploidy as a marker, thus decreasing the rate of cytologically equivocal diagnoses in effusions.
K Kayser, G Kayser, S Eichhorn, U Biechele, M Altiner, H Kaltner, F Y Zeng, E V Vlasova, N V Bovin, H J Gabius
Association of prognosis in surgically treated lung cancer patients with cytometric, histometric and ligand histochemical properties: with an emphasis on structural entropy
1998 Aug;20(4):313-20
Abstract: To explore new tumor features for refined category formation that permits the tailoring of individualized treatment schemes in lung cancer.
R W Mackin Jr, L M Newton, J N Turner, B Roysam
Advances in high-speed, three-dimensional imaging and automated segmentation algorithms for thick and overlapped clusters in cytologic preparations. Application to cervical smears
1998 Apr;20(2):105-21
Abstract: To use three-dimensional (3-D) imaging and localized adaptive image analysis to enable automated cervical smear screening systems to efficiently and effectively process thick and overlapped cell clusters currently left unprocessed.
H Motherby, T Marcy, M Hecker, B Ross, B Nadjari, H Auer, K M Müller, D Häussinger, B E Strauer, A Böcking
Static DNA cytometry as a diagnostic aid in effusion cytology: I. DNA aneuploidy for identification and differentiation of primary and secondary tumors of the serous membranes
1998 Jun;20(3):153-61
Abstract: To determine whether DNA aneuploidy is a sensitive and specific marker for the identification of tumor cells in effusions and whether the pattern of DNA aneuploidy can provide important information for the differential diagnosis of primary and secondary tumors of the serous membranes.
B Ross, H Motherby, F Saurenbach, J Frohn, M Kube, A Böcking
Atomic force microscopy in effusion cytology
1998 Apr;20(2):97-104
Abstract: To investigate whether atomic force microscopy (AFM) in combination with classical light microscopy allows simple identification of surface structures of cells from pleural and ascitic fluids for diagnostic purposes in place of scanning electron microscopy (SEM).
P H Bartels, R Montironi, P W Hamilton, D Thompson, L Vaught, H G Bartels
Nuclear chromatin texture in prostatic lesions. I. PIN and adenocarcinoma
1998 Oct;20(5):389-96
Abstract: To document changes in the chromatin pattern in secretory cell nuclei from prostates with prostatic intraepithelial neoplasia (PIN) or adenocarcinoma.
G Haroske, W Meyer, F Theissig, K Schubert, K D Kunze
Remote quantitation server for quality assurance in DNA ploidy analysis
Comparative Study: 1998 Aug;20(4):302-12
Abstract: To remotely test a stepwise framework of quality control measures, developed according to the 1997 European Society of Analytical Cellular Pathology consensus on diagnostic DNA image cytometry, in two series of measurements by means of the quantitation server EUROQUANT.
R Montironi, R Mazzucchelli, A Santinelli, P W Hamilton, D Thompson, P H Bartels
Case diagnosis as positive identification in prostatic neoplasia
1998 Oct;20(5):424-36
Abstract: To apply a distance measure and Bayesian belief network-based methodology to the positive identification of case diagnosis in prostatic neoplasia.
P H Bartels, V D da Silva, R Montironi, P W Hamilton, D Thompson, L Vaught, H G Bartels
Chromatin texture signatures in nuclei from prostate lesions
1998 Oct;20(5):407-16
Abstract: To characterize nuclei from prostatic lesions in a highly specific manner by developing a nuclear chromatin texture signature and to characterize lesions by means of their composition of nuclei with diverse degrees of deviation from normal.
M R Cardillo, E Petrangeli, L Ravenna, L Salvatori, F Di Silverio
Transforming growth factor-beta expression in human testicular neoplasms
1998 Dec;20(6):461-9
Abstract: To investigate the localization of transforming growth factors (TGF-beta 1, -beta 2 and -beta 3) and their receptors (TGF-beta RI and RII).
S Staibano, P Orabona, E Mezza, G Salvatore, F Tranfa, D Capone, M E Errico, G Bonavolontà, A Lucariello, G De Rosa
Morphometric analysis of AgNORs in uveal malignant melanoma
Comparative Study: 1998 Dec;20(6):483-92
Abstract: To define the value of silver-stained nucleolar organizer regions (AgNOR) in the evaluation of uveal malignant melanomas (MM).
P H Bartels, H G Bartels, R Montironi, P W Hamilton, D Thompson
Machine vision in the detection of prostate lesions in histologic sections
1998 Oct;20(5):358-64
Abstract: To explore the utility of N-gram encoding for the automated detection and delineation of regions of histologic abnormality in tissue sections of prostate.
R W Mackin Jr, L M Newton, J N Turner, T J Holmes, B Roysam
Accuracy of nuclear classification in cervical smear images. Quantitative impact of computational deconvolution and 3-D feature computation
1998 Apr;20(2):77-91
Abstract: To investigate the accuracy with which the nuclei of cells in overlapped and thick clusters in cervical/vaginal smears can be classified independent of the segmentation algorithm used and to determine the influence of three-dimensional (3-D) processing as compared to two-dimensional (2-D) methods on classification of the nuclei.
R Kiss, C Decaestecker, I Camby, F Darro, I Salmon, A Danguy, J L Pasteels, P Yeaton
Direct relationship between hormone sensitivity level and growth pattern. Evidence in 18 gastrointestinal neoplastic cell lines
1998 Apr;20(2):133-43
Abstract: We investigated whether a relationship exists in terms of growth pattern and hormone sensitivity in 18 gastrointestinal neoplastic cell lines. Hormones studied included gastrin, epidermal growth factor, estradiol and luteinizing hormone-releasing hormone.
G Fadda, C Minimo, C Rabitti, G Balsamo, A Verzì, G Gullotta, M Lancia, A Bianchi, A Capelli
Role of planimetric analysis in diagnosing thyroid follicular lesions on fine needle aspiration biopsies: a study with histologic correlation
1998 Jun;20(3):192-8
Abstract: Follicular lesions represent a gray area of interpretation in fine needle aspiration biopsy (FNAB) of the thyroid, with as much as 25% inconclusive reports. We identified "predominantly follicular lesions" (PFLs) as the cytologic category most apt to take advantage of planimetric analysis to reach a more definitive diagnosis.
V Enchev
DNA ploidy and morphometric features of normal, hyperplastic, premalignant and malignant specimens: an evaluation
Comparative Study: 1998 Aug;20(4):288-96
Abstract: To evaluate nuclear DNA assessments and morphometric variables on various breast cytologic smears and paraffin-embedded tissue sections of human breast and gastric lesions.
F Altenstrasser, A R Weger, J Lindholm, A Gschwendter, T Mairinger
Reproducibility and efficiency testing of two sampling methods for image analysis in cytology
Comparative Study: 1998 Apr;20(2):92-6
Abstract: Quantitative nuclear DNA analyses and nuclear morphometry have become a widely used tool in pathology. Nevertheless, studies done by different observers utilizing the same methods very often have shown different results. One of the reasons could be that different sampling methods were used. In this study two selection methods for image analyses (the consecutive selection method and the random selection method) were tested for reproducibility and efficiency.
C W Patrick Jr, J Friedrich, M J Miller
Computer-assisted histometric analysis of tissue-engineered ovine bone
1998 Jun;20(3):199-206
Abstract: To develop a computer-assisted histometric technique that quantitatively determines the amount of regenerating bone, while excluding fibrovascular tissue and void spaces, in tissue-engineered bone constructs. To this end, a histometric technique was developed that couples digital tiling with adaptive, multiband color thresholding (AMBCT).
J W Bishop, K L Sims
Cellular morphometry in nongynecologic thin-layer and filter cytologic specimens
Comparative Study: 1998 Aug;20(4):257-67
Abstract: To determine the feasibility and utility of thin-layer cytology preparations for morphometric analysis of nuclear and cytoplasmic area in cells from nongynecologic cytology specimens.
K A Alanen, M Lintu, H Joensuu
Image cytometry of breast carcinomas that are DNA diploid by flow cytometry: time to revise the concept of DNA diploidy?
Comparative Study: 1998 Jun;20(3):178-86
Abstract: To investigate whether breast carcinomas found to be DNA diploid by flow cytometry (FCM) are still diploid if reassessed by image cytometry (ICM).
E M Wojcik, M C Miller, G J O'Dowd, R W Veltri
Value of computer-assisted quantitative nuclear grading in differentiation of normal urothelial cells from low- and high-grade transitional cell carcinoma
1998 Feb;20(1):69-76
Abstract: To evaluate the ability of computer-assisted quantitative nuclear grading (QNG) using a microspectrophotometer and morphometry software to differentiate Feulgen-stained nuclei captured from normal urothelium, low grade transitional cell carcinoma (LG-TCC) and high grade transitional cell carcinoma (HG-TCC) cytology specimens.
B Baldetorp, M Fernö, P O Bendahl, G Fallenius, I Idvall, M Akerman, D Killander
Proliferative index obtained by DNA image cytometry. Does it add prognostic information in Auer IV breast cancer?
1998 Apr;20(2):144-52
Abstract: To investigate whether the S + G2/M fraction (proliferative index) is a prognostic determinant in breast cancers classified as Auer IV.
A Moragas, H Allende, M Sans
Characteristics of perisinusoidal collagenization in liver cirrhosis: computer-assisted quantitative analysis
1998 Jun;20(3):169-77
Abstract: To determine the respective roles of septal fibrosis, necroinflammatory activity, iron deposition, steatosis, and patterns of nodular and septal remodeling in the collagenization of the perisinusoidal space in livers from patients undergoing transplantation for alcoholic or posthepatitis C cirrhosis and to ascertain whether perisinusoidal collagenization has clinical implications added to those of septal fibrosis.
W Gorczyca, M Davidian, J Gherson, R Ashikari, Z Darzynkiewicz, M R Melamed
Laser scanning cytometry (LSC) quantification of estrogen receptors in breast cancer
Comparative Study: 1998 Dec;20(6):470-6
Abstract: To describe the laser scanning cytometry (LSC) processing and analysis developed for the quantitative analysis of estrogen receptor (ER) content in routine paraffin sections of breast carcinomas.
P H Bartels, R Montironi, P W Hamilton, D Thompson, L Vaught, H G Bartels
Nuclear chromatin texture in prostatic lesions. II. PIN and malignancy associated changes
1998 Oct;20(5):397-406
Abstract: The objective of this study was to identify and document prostatic intraepithelial neoplasia (PIN) and malignancy associated changes in secretory cell nuclei from visually normal appearing tissue regions of prostates harboring PIN or adenocarcinoma.
P H Bartels, R Montironi, D Thompson, L Vaught, P W Hamilton
Statistical histometry of the basal cell/secretory cell bilayer in prostatic intraepithelial neoplasia
1998 Oct;20(5):381-8
Abstract: To delineate the sampling requirements for a histometric assessment of progression in low grade and high grade prostatic intraepithelial neoplasia (PIN) lesions.
C Herrera-Espiñeira, C Marcos-Muñoz, J Esquivias
Automated segmentation of cell nuclei in fine needle aspirates of the breast
1998 Feb;20(1):29-35
Abstract: To achieve a classifier of breast lesions to discriminate between benign and malignant cases of cytologic smears with automated segmentation image analysis techniques.
O V Chistyakova, G N Zubrikhina
Flow cytometric analysis of DNA content in gastric and colorectal cancer
1998 Feb;20(1):52-8
Abstract: Analysis of DNA ploidy and proliferative activity by flow cytometry (FCM) of gastric (GC) and colorectal cancer with morphology (histology and cytology) and prognostic correlation was performed.
S Biesterfeld, E Hoffmann
MIB-1 immunohistometry on Tru-cut biopsies in inflammatory and cirrhotic liver disease
1998 Aug;20(4):268-74
Abstract: To use immunohistometry to analyze the MIB-1 immunopositivity of normal liver parenchyma (n = 25) and of different inflammatory and degenerative liver diseases--including nonspecific inflammation (n = 12), toxic-nutritive (alcoholic) inflammation (n = 12), ascending cholangitis (n = 11), chronic-persisting hepatitis (n = 27), chronic-aggressive hepatitis (n = 28) and liver cirrhosis (n = 23).
L Shechtman, R Koren, A Horowitz, I Shechtman, M Halpern, R Gal
Diagnostic value of AgNOR staining in thyroid cytology
1998 Jun;20(3):187-91
Abstract: To determine the value of the argyrophil nucleolar organizer region (AgNOR) technique on scrape cytology of thyroid lesions.
J W Bishop, K MacFarlane, D Cheuvront, K L Sims
Cell recovery and appearance in thin-layer preparations in nongynecologic cytology
Comparative Study: 1998 Aug;20(4):229-37
Abstract: To compare the diagnostic efficacy of a thin-layer technique with that of a membrane filter technique using a wide variety of fresh cytologic specimens.
C François, C Decaestecker, I Salmon, M Pétein, M Remmelink, T Janssen, A Peltier, E Wespes, C Schulman, R van Velthoven, R Kiss
Prognostic value of stem cell line identification for renal cell carcinomas
1998 Jun;20(3):207-14
Abstract: To investigate the prognostic value of nuclear DNA content (DNA ploidy level) in a series of 95 renal cell carcinomas (RCCs).
K P de Jong, M A Brouwers, G A Huls, A Dam, J C Bun, A S Wubbena, P Nieuwenhuis, M J Slooff
Liver cell proliferation after partial hepatectomy in rats with liver metastases
1998 Feb;20(1):59-68
Abstract: To validate proliferating cell nuclear antigen (PCNA) expression and flow cytometry as proliferation markers in regenerating rat liver containing metastases.
G Wolf, I Petersen, M Dietel
Microscope remote control with an Internet browser
1998 Apr;20(2):127-32
Abstract: To develop a telemicroscopy system that is independent of specialized hardware and software for microscope remote control.
V G Enchev, E Gavrilova
Comparison of quantitative variables between patients with relatively normal and gastritis-altered mucosae
1998 Feb;20(1):36-42
Abstract: To develop a statistical (regression) analysis of quantitative patterns of human epithelial nuclear and cellular profiles from chronic atrophic and hypertrophic gastritis, excluding Menetrier's gastropathy.
E Kahn, C Philippe, F Frouin, R Di Paola, A Bernheim
Characterization of cosmids and telomeres in cytogenetic preparations by 3D confocal fluorescence
1998 Dec;20(6):517-20
Abstract: To analyze, with fluorescent probes, by three-dimensional (3D) emission patterns, fluorescence in situ hybridization (FISH) preparations (cosmids, telomeres) and to perform factor analysis of medical image sequences (FAMIS); to use FISH to track relevant DNA sequences in cell nuclei during interphase and in mitotic chromosomes; and to use cytogenetic techniques, resulting in flat preparations of whole cells that are assumed to preserve probe access to their targets.
C Bertoni-Freddari, P Fattoretti, R Ricciuti, S Vecchioni, U Caselli, R Paoloni, A Ducati
Effect of age on synaptic size in human brain tissue proximal to tumor masses
1998 Dec;20(6):517-20
Abstract: To measure the effect of age on synaptic morphologic rearrangements in human brain tissue peripheral to space-occupying lesions.
T Irinopoulou, J Vassy, J P Rigaut
Application of confocal scanning laser microscopy to 3-D DNA image cytometry of prostatic lesions
1998 Oct;20(5):351-7
Abstract: To explore the potential of three-dimensional (3-D) image cytometry for the measurement of DNA content in prostatic specimens using confocal scanning laser microscopy (CSLM) and 3-D image analysis.
N Bakshi, A Rajwanshi, F Patel, N K Ganguly
Prognostic significance of DNA ploidy and S-phase fraction in malignant serous cystadenocarcinoma of the ovary
1998 Jun;20(3):215-20
Abstract: To determine the prognostic value of DNA ploidy and S-phase fraction in malignant serous cystadenocarcinoma of the ovary.
A B Houtsmuller, P J Janssen, A L Nigg, R F Hoedemaeker, T H van der Kwast
Quantitative immunohistochemistry of androgen receptors in a microsphere model system and in prostate tissue sections
Comparative Study: 1998 Oct;20(5):365-72
Abstract: To evaluate androgen receptor (AR) levels to predict endocrine therapy response and prognosis.
H Shimizu, K Suda
2-D index as a measure for estimating the complexity degree of 3-D sinusoidal structures in the normal and cirrhotic liver and in hepatocellular carcinoma
1998 Dec;20(6):526-8
Abstract: To evaluate the usefulness of a two-dimensional (2-D) index from a single tissue section as a measure for estimating the complexity degree of three-dimensional (3-D) sinusoidal structure in normal and cirrhotic liver and in hepatocellular carcinoma (HCC).
T Sauer, E Beraki, P W Jebsen, E Amlie, T Harbitz, R Kåresen, O Naess
Assessing estrogen and progesterone receptor status in fine needle aspirates from breast carcinomas. Results on six years of material and correlation with biochemical assay
1998 Apr;20(2):122-6
Abstract: To evaluate the usefulness of immunocytochemical staining on breast fine needle aspiration (FNA) cytology as a routine procedure for determination of estrogen (ER) and progesterone (PR) receptor status.
A N Esgiar, R N Naguib, M K Bennett, A Murray
Automated feature extraction and identification of colon carcinoma
1998 Aug;20(4):297-301
Abstract: To assess an automated algorithm, developed for the classification of normal and cancerous colonic mucosa, using geometric analysis of features and texture analysis.
R Schimming, M Hlawitschka, G Haroske, U Eckelt
Prognostic relevance of DNA image cytometry in oral cavity carcinomas
1998 Feb;20(1):43-51
Abstract: To evaluate the relation of DNA content of squamous cell carcinomas of the oral cavity to clinicopathologic features by image cytometry.
T Takamatsu
Confocal microscopy. Applications in research and practice of pathology
1998 Dec;20(6):521-5
Abstract: To discuss recent advances in the use of confocal microscopy to perform quantitative analysis of physiologic and pathologic intracellular events in the living organ.
J Smolle
Fractal tumor stromal border in a nonequilibrium growth model
1998 Feb;20(1):7-13
Abstract: To examine the potential relationships of tumor growth parameters and fractal dimensionality of the resulting pattern.
P Fattoretti, C Bertoni-Freddari, U Caselli, R Paoloni, T Casoli
Quantitative cytochemistry of succinic dehydrogenase activity in rat mitochondria
1998 Dec;20(6):521-5
Abstract: To set up a computer-assisted morphometric procedure to cytochemically measure the activity of succinic dehydrogenase (SDH).
J Azúa, P Romeo, M Morales, T Castiella, J Azúa Jr
DNA quantification as a prognostic factor in gastric adenocarcinoma
1998 Jun;20(3):221-4
Abstract: To determine if DNA quantification, studied in cytologic samples obtained by fiberendoscopy, has predictive value in gastric adenocarcinoma. The survival times of patients in whom the tumor was the cause of death were considered variables of interest.

Volume 14 (1998) Issue 1 - Issue 6

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