Volume 13 (1997) Issue 1 - Issue 6 | Analytical and quantitative cytology and histology

Volume 13 (1997) Issue 1 - Issue 6

G Casartelli, S Monteghirfo, M De Ferrari, S Bonatti, M Scala, S Toma, G Margarino, A Abbondandolo
Staining of micronuclei in squamous epithelial cells of human oral mucosa
1997 Dec;19(6):475-81
Abstract: To evaluate the influence of methodologic variables, staining method and sampling, on the frequency of micronuclei scored in squamous epithelial cells of oral mucosa. Micronuclei were used as biomarkers of structural and numerical chromosome damage.
W Polkowski, G A Meijer, J P Baak, F J ten Kate, H Obertop, G J Offerhaus, J J van Lanschot
Reproducibility of p53 and Ki-67 immunoquantitation in Barrett's esophagus
1997 Jun;19(3):246-54
Abstract: To test the reproducibility and time effectiveness of two immunoquantitation and sampling methods in Barrett's esophagus (BE) mucosa.
J Domagała-Kulawik, G Hoser, M Kawalec, A Doboszyńska, J Kawiak, W Droszcz
Lymphocyte phenotyping in systemic sclerosis: a flow cytometry analysis of lymphocytes in bronchoalveolar lavage fluid
1997 Jun;19(3):264-70
Abstract: Patients with scleroderma (systemic sclerosis [SSc]) frequently develop interstitial lung disease. The purpose of this work was to evaluate the cell profile in the bronchoalveolar lavage fluid (BALF) in patients suffering from a diffuse form of systemic sclerosis as compared with healthy controls.
S Bacus, D Chin, J Stewart, C Zelnick, D Mahvi, K Gilchrist
Potential use of image analysis for the evaluation of cellular predicting factors for therapeutic response in breast cancers
Review: 1997 Aug;19(4):316-28
Abstract: To summarize the current literature on the association between biologic prognostic factors and therapeutic implications.
C R Laverty, A Farnsworth, J K Thurloe, A Grieves, R Bowditch
Evaluation of the CytoRich slide preparation process
Comparative Study: 1997 Jun;19(3):239-45
Abstract: To compare the quality and sensitivity of CytoRich slides with conventional cytologic smears and to evaluate the benefits of using this technology as an add-on procedure.
A C Ruifrok
Quantification of immunohistochemical staining by color translation and automated thresholding
1997 Apr;19(2):107-13
Abstract: To develop a method of quantitating immunohistochemical staining using diaminobenzidine (DAB) and hematoxylin by means of color image analysis.
M Brinkhuis, C Scheepstra, M R Buist, P J van Diest, J P Baak
Intratumor heterogeneity of morphometric and stereologic variables in primary ovarian tumors and their omental metastatic deposits
Comparative Study: 1997 Jun;19(3):185-93
Abstract: To compare quantitative pathologic variables assessed in primary ovarian tumors and metastatic tumor deposits in the omentum and compare their prognostic value.
T H Tsai, T C Chang, C P Chiang
Nuclear area measurements of parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma. A comparison
Comparative Study: 1997 Feb;19(1):45-8
Abstract: To determine whether nuclear area (NA) measurement could help to differentiate parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma in aspirated smears.
M Scarpelli, R Montironi, D Thompson, P H Bartels
Computer-assisted discrimination of glioblastomas
1997 Oct;19(5):369-75
Abstract: To measure a number of nuclear features in a series of glioblastomas and compare the data with those from a set of anaplastic and low grade astrocytomas.
A J Einstein, G C Yang, J B Silberfarb, J Gil
Effect of ultrafast Papanicolaou staining on nuclear and textural features in breast cancer cytology
Comparative Study: 1997 Aug;19(4):361-7
Abstract: To compare quantifiable cytologic features of mammary lesions prepared using the Ultrafast Papanicolaou, Diff-Quik and Papanicolaou methods.
J Gosálvez, I Buño, C López-Fernández, J L Fernández, V J Goyanes
Image analysis of murine chromatin fiber structure after in situ digestion with restriction endonucleases
1997 Jun;19(3):207-14
Abstract: To determine and quantify the differences produced in chromatin structure after selective in situ DNA digestion with restriction endonuclease (RE).
K Roth, G Wolf, M Dietel, I Petersen
Image analysis for comparative genomic hybridization based on a karyotyping program for windows
Comparative Study: 1997 Dec;19(6):461-74
Abstract: To describe the image processing and analysis techniques we developed for the quantitative analysis of comparative genomic hybridization (CGH).
P Karakitsos, E B Stergiou, A Pouliakis, M Tzivras, A Archimandritis, A Liossi, K Kyrkou
Comparative study of artificial neural networks in the discrimination between benign from malignant gastric cells
Comparative Study: 1997 Apr;19(2):145-52
Abstract: To compare the accuracy of two different artificial neural networks (ANNs) for the discrimination of benign and malignant gastric lesions using morphometric and textural data on the nucleus.
G L Ottesen, I J Christensen, J K Larsen, J Larsen, J Christiansen, B Baldetorp, T Linden, B Hansen, J A Andersen
DNA ploidy analysis in breast carcinoma. Comparison of unfixed and fixed tissue analyzed by image and flow cytometry
Comparative Study: 1997 Oct;19(5):413-22
Abstract: To form a methodologic basis for DNA analysis of ductal carcinoma in situ (DCIS) and invasive carcinoma (IC) of the breast, including very small lesions, by comparison of flow cytometric (FCM) and image cytometric (ICM) methods for DNA quantitation.
E M Wojcik, M C Miller, B C Wright, R W Veltri, G J O'Dowd
Comparative analysis of DNA content in polyomavirus-infected urothelial cells, urothelial dysplasia and high grade transitional cell carcinoma
Comparative Study: 1997 Oct;19(5):430-6
Abstract: To characterize the DNA content pattern in cytologically confirmed polyomavirus (PV)-infected urothelial cells and to compare it with DNA ploidy changes in cytologically diagnosed urothelial dysplasia and high grade transitional cell carcinoma.
Z Zhang, Z Suo, J Sudbø, R Holm, M Boysen, A Reith
Diagnostic implications of p53 protein reactivity in nasal mucosa of nickel workers
1997 Aug;19(4):345-50
Abstract: To investigate whether the quantitation of p53 protein reactivity in nasal biopsies could be related to nickel exposure by comparing nickel workers with various control groups.
S K Sarker, R Mendiola, M Walker, D V Coleman
Quantitative measurement of estrogen and progesterone receptors in breast lumps using image cytometry
1997 Feb;19(1):87-91
Abstract: To evaluate image cytometry for detecting estrogen (ER) and progesterone receptors (PR) in breast lumps quantitatively.
E L Held, A A Gal, P B DeRose, C Cohen
Image cytometric nuclear DNA quantitation of paragangliomas in tissue sections. Prognostic significance
1997 Dec;19(6):501-6
Abstract: Image cytometric quantitation of nuclear DNA of paragangliomas may provide prognostic information that cannot be obtained from histopathologic study. Flow cytometry has demonstrated DNA aneuploid tumors to have a higher risk of progression than diploid neoplasms.
P Melsheimer, K Grunwald, K Feldmann, T Rabe, B Runnebaum, H H Rummel
Aneuploidy of human granulosa cells in follicular fluids from in vitro fertilization patients
1997 Feb;19(1):75-9
Abstract: To study the proliferative behavior of granulosa cells found in follicular fluids from patients after hormone stimulation in the framework of in vitro fertilization (IVF) with gonadotropins.
M Ladekarl, V Jensen, B Nielsen
Total number of cancer cell nuclei and mitoses in breast tumors estimated by the optical disector
1997 Aug;19(4):329-37
Abstract: The total number of cancer cell nuclei, N(nuc), and of mitoses, N(mit), in the primary lesion are potentially important indicators of tumor biology. In the present study, such estimates were obtained on breast cancers by an unbiased stereologic method.
M Scarpelli, R Montironi, D Thompson, P H Bartels
Computer-assisted analysis of medulloblastoma. A cytologic study
1997 Oct;19(5):387-92
Abstract: To explore data from a set of cases of medulloblastoma to see whether quantitative image analysis might suggest evidence for the existence of lower and higher grade lesions.
C Markopoulos, P Karakitsos, E Botsoli-Stergiou, A Pouliakis, A Ioakim-Liossi, K Kyrkou, J Gogas
Application of the learning vector quantizer to the classification of breast lesions
1997 Oct;19(5):453-60
Abstract: To investigate the potential of the learning vector quantization (LVQ) neural network for the discrimination of benign from malignant breast lesions.
M Brinkhuis, G A Meijer, P J van Diest, L T Schuurmans, J P Baak
Minimum spanning tree analysis in advanced ovarian carcinoma. An investigation of sampling methods, reproducibility and correlation with histologic grade
1997 Jun;19(3):194-201
Abstract: To investigate sampling methods and reproducibility of minimum spanning tree (MST) variables in advanced ovarian cancer and their discriminative power for histologic grade.
E Bergers, P J van Diest, J P Baak
Reliable DNA histogram interpretation. Number of nuclei requiring measurement with flow cytometry
1997 Aug;19(4):277-84
Abstract: The reasons for conflicting prognostic results as to DNA ploidy and cell cycle variables (DNA index, percent S (%S) phase) may be found mainly at different levels of the flow cytometric methodology used. The present study concentrated on how many nuclei have to be measured with flow cytometry for reliable DNA histogram interpretation.
L S Hibbard, D W McKeel Jr
Automated identification and quantitative morphometry of the senile plaques of Alzheimer's disease
1997 Apr;19(2):123-38
Abstract: Senile plaques (SP) are one of the characteristic neuropathologic lesions of Alzheimer's Disease (AD), and studies of SP cortical distribution, density and morphology may lead to new information about the mechanism and pathogenesis of AD. We used an automated, digital image analysis program to detect and measure SP size, shape and total fractional area in digital images of silver-stained tissue sections.
A Faranda, A Costa, S Canova, G Abolafio, R Silvestrini
Image and flow cytometric analyses of DNA content in human solid tumors. A comparative study
Comparative Study: 1997 Aug;19(4):338-44
Abstract: To compare the sensitivity and potentials of flow and image cytometry in assessing DNA content.
P Kronqvist, R Montironi, T Kuopio, Y U Collan
Subjective breast cancer grading. Analyses of reproducibility after application of Bayesian belief networks
1997 Aug;19(4):361-7
Abstract: To examine the influence of Bayesian belief networks (BBNs) on the reproducibility of subjective breast cancer grading.
D Goldschmidt, L Gordower, J V Berthe, M Remmelink, C Decaestecker, M Petein, I Salmon, R Kiss, A Danguy
Contribution of quantitative lectin histochemistry to characterizing well-differentiated, dedifferentiated and poorly differentiated liposarcomas
1997 Jun;19(3):215-26
Abstract: To find new diagnostic markers in the group of lipomatous tumors.
G Büsche, J Schlué, A Georgii
Square sampling. An easy method of estimating numerical densities of cells or particles within a tissue
1997 Dec;19(6):489-500
Abstract: A new parametric method is presented, called "square sampling," which speeds up the estimate of the number of cells or particles that are randomly distributed within a tissue.
M Bellotti, B Elsner, A Kahn, L Bezodnick, L Pisilli, P Greco
Morphometric determination of AgNORs in breast carcinoma. Correlation with flow cytometry and proliferating cell nuclear antigen
1997 Apr;19(2):139-44
Abstract: To determine the relationship between argyrophilic nucleolar organizer regions (AgNORs), ploidy and proliferative activity in breast carcinomas.
J Dusková, C Povýsil, V Schreiber
AgNORs in estrogen-induced and lisuride- and thyreoidin-inhibited rat anterior pituitary hyperplasia. Computer image analysis and nonautomated AgNOR typing
1997 Feb;19(1):55-61
Abstract: A model of estrogen (E)-induced rat anterior pituitary hyperplasia blocked partly by thyroid hormones (estradiol plus thyreoidin [ET]) and nearly completely by lisuride (estradiol plus lisuride [EL]) and thyreoidin plus lisuride combination (estradiol plus thyreoidin plus lisuride [ETL]) was used to test a computer image analysis program, LUCIA, for argyrophilic nucleolar organizer region (AgNOR) evaluation.
C Mainguené, C Choquenet, C Deplano, A Gavelli, N Clément, E Vanzo, P Hofman
DNA ploidy by image cytometry in urothelial carcinomas. Comparison of touch imprints and paraffin-embedded biopsies from 31 patients
Comparative Study: 1997 Oct;19(5):437-42
Abstract: To compare DNA content measured by image cytometry from touch imprints and formalin-fixed, paraffin-embedded samples in bladder carcinomas.
U Schenck, U Jütting, K Rodenacker
Modeling, definition and applications of histogram features based on DNA values weighed by sine functions
1997 Oct;19(5):443-52
Abstract: To model new DNA histogram features that weigh DNA values with values of curves of a sine function and to show the definition and applications of such features.
E Kaczmarek, R L Becker Jr
Three-dimensional modeling of renal glomerular capillary networks
1997 Apr;19(2):93-101
Abstract: To quantitatively characterize three-dimensional (3D) vascular patterns based on the path length distribution in networks.
F Willemse, M Nap, H W de Bruijn, H Hollema
Quantification of vascular density and of lumen and vessel morphology in endometrial carcinoma. Evaluation of their relation to serum levels of tissue polypeptide-specific antigen and CA-125
1997 Feb;19(1):1-7
Abstract: To determine whether differences in tumor vessel architecture influence the entry of tumor-associated antigens into the circulation.
F Duigou, I Galle, P Herlin, A M Mandard
Improvements in slide preparation from archival material for automated DNA measurement by image analysis
1997 Apr;19(2):167-73
Abstract: To optimize slide preparation for DNA content measurement by automated image analysis and to obtain a rapid and easy method for routine use.
C Boudry, P Herlin, M Coster, B Sola, J L Chermant
Influence of debris and aggregates on image cytometry DNA measurement of archival tumors
1997 Apr;19(2):153-7
Abstract: To investigate, for seven samples, the influence of unwanted elements (e.g., remains of erythrocyte cell membranes, sliced nuclei, damaged nuclei and aggregates) on image cytometry DNA ploidy measurements.
M Briffod, V Le Doussal, F Spyratos
Cytologic nuclear grading of fine needle cytopunctures of breast carcinoma. Comparison with histologic nuclear grading and image cytometric data
Clinical Trial: 1997 Apr;19(2):114-22
Abstract: To evaluate nuclear grading on fine needle cytopunctures of breast carcinoma, which is of special interest when neoadjuvant chemotherapy is planned.
R A Williams, J P Baak, G A Meijer, I G Charlton
Exploring the possibility of DNA ploidy measurements in tissue sections using liver as a model
1997 Feb;19(1):19-29
Abstract: To evaluate DNA image cytometry (ICM) in tissue sections, human and rat liver was used as a model. These tissues have distinct DNA ploidy histograms of mainly diploid (human) and predominantly tetraploid (rat) plus octaploid nuclei.
I Niedermayer, H Kolles, W Feiden
Histologic and morphometric grading of gliomas. A comparative survival analysis
Comparative Study: 1997 Aug;19(4):301-10
Abstract: A grading system based upon morphometrically assessed quantitative parameters (HOM system) was correlated with the results of classical histologic grading (St. Anne/Mayo system [SAMS], 1988, and World Health Organization classification, 1993). Validation was done by comparison with survival data.
Y C Lee, J H Chern, W Y Li, M H Huang, R P Perng
AgNORs in lung cancer: correlation with DNA ploidy and degree of differentiation
1997 Jun;19(3):271-6
Abstract: To assess the usefulness of enumerating argyrophilic nucleolar organizer regions (AgNORs) in assisting with the diagnosis, as well as its correlation with the degree of differentiation and DNA ploidy, in lung cancer.
C Charpin, S Garcia, A Chernaiev, O Grobova, D Charpin, D Hoffschir, C Voisin, A Chuchalin
Morphometry and densitometry of alveolar macrophage cytoplasmic particles in Chernobyl, Ukraine, liquidators
1997 Feb;19(1):37-44
Abstract: To characterize intracytoplasmic particles found in alveolar macrophages (AMs) sampled by bronchial alveolar lavage (BAL) performed on Chernobyl, Ukraine, liquidators suffering from chronic obstructive lung disease.
N J Hawkins, J Lees, R L Ward
Detection of apoptosis in colorectal carcinoma by light microscopy and in situ end labelling
Comparative Study: 1997 Jun;19(3):227-32
Abstract: An in situ end labelling reaction (ISEL) was recently described for the detection of apoptotic cells in histologic sections. We compared the efficiency and reproducibility of this assay with those of routine light microscopy using hematoxylin and eosin (H&E) in the quantitation of apoptotic cells in colorectal cancer.
L P Setälä, S Nordling, V M Kosma, P K Lipponen, M J Eskelinen, S M Hollmén, K J Syrjänen, E M Alhava
Comparison of DNA ploidy and S-phase fraction with prognostic factors in gastric cancer
Comparative Study: 1997 Dec;19(6):524-32
Abstract: To assess the value of DNA ploidy and S-phase fraction (SPF) as prognostic factors in gastric cancer.
K W Zieliński, K Trojanowski, A Kulig, P Siermontowski
Densitometric and chromatin texture parameters of hepatocyte nuclei during controlled autolysis
1997 Aug;19(4):351-60
Abstract: To determine the extent of the effect of autolytic changes in hepatocyte nuclei on the results of measurements of integrated optical density (IOD) of nuclei stained by the Feulgen method and its possible relationship with changes in chromatin texture.
E Kahn, F Frouin, J Hotmar, R Di Paola, A Bernheim
Confocal fluorescence analysis of the depth and focus of cytogenetic preparations
1997 Oct;19(5):404-12
Abstract: To characterize differences in the depth of fluorescent probes, to observe estimated depth levels (focal planes) on fluorescent in situ hybridization preparations by factor analysis of medical image sequences and to use cytogenetic techniques resulting in flat preparations of whole cells that are assumed to preserve the probes' access to their targets in the human nuclear interphase.
J Azúa, P Romeo, M Serrano, D Martinez Tello, J Azúa Jr
Prognostic value from DNA quantification by static cytometry in breast cancer
1997 Feb;19(1):80-6
Abstract: To determine if DNA quantification on fine needle aspiration (FNA) has predictive value in breast cancer.
V Enchev, J Angelova, J Peneva
Consultation system for diagnosis of gastric lesions
1997 Feb;19(1):13-8
Abstract: To present a knowledge-based classification system, GASTRO, for gastric lesion diagnosis.
C Herrera-Espiñeira, C Marcos-Muñoz, J E López-Cuervo
Diagnosis of breast cancer by measuring nuclear disorder using planar graphs
1997 Dec;19(6):519-23
Abstract: To achieve a classifier of breast lesions to distinguish benign from malignant mammary lesions by quantifying nuclear disorder in epithelial cell groups from smears obtained by fine needle aspiration.
M F Mauri, S Boi, R Micciolo, M Cristofolini, P Dalla Palma
Morphometric analysis in prognostic evaluation of stage I thick cutaneous melanomas
1997 Aug;19(4):311-5
Abstract: To determine if morphometric analysis could be useful in distinguishing between good and adverse prognosis in thick melanomas.
T Wrzołkowa, K Schramm, C Tukaj, E Marczak, M Kraszpulski
Interstitial tissue fraction. The prognostic marker in membranoproliferative glomerulonephritis in children
1997 Feb;19(1):8-12
Abstract: To explain the differences in the clinical course of membranoproliferative glomerulonephritis (MPGN) in children and to find some prognostic markers at the disease onset that correlate with the disease outcome.
K Fujikawa
Analytical comparison of volume-weighted mean nuclear volume between specimens from transrectal biopsy and transurethral resection of the prostate
Comparative Study: 1997 Aug;19(4):368
Z Zhang, M Nakamura, E Taniguchi, L Shan, T Yokoi, K Kakudo
A simple approach to single-cell microdissection and molecular analysis
1997 Dec;19(6):514-8
Abstract: To develop a simple approach to single-cell microdissection from Papanicolaou-stained smears and to determine its usefulness in molecular diagnosis using archival cytologic material.
L A Talve, Y U Collan, T O Ekfors
Primary malignant melanoma of the skin. Relationships of nuclear DNA content, nuclear morphometric variables, Clark level and tumor thickness
1997 Feb;19(1):62-74
Abstract: To investigate how nuclear morphometric variables, tumor thickness (measured according to Breslow), invasion depth (classified according to Clark), nuclear DNA content and type of DNA histogram are associated with each other in primary malignant melanomas of the skin.
L A Talve, Y U Collan, T O Ekfors
P90 exceeding rate as a prognostic factor in primary malignant melanoma of the skin. A DNA image cytometric study
1997 Oct;19(5):393-403
Abstract: To study the prognostic value of DNA image cytometry in primary skin melanomas.
V D da Silva, J C Prolla, A R Diehl, M F Baldo, R L Müller
Comparison of conventional microscopy and digitized imaging for diagnosis in serous effusions
Comparative Study: 1997 Jun;19(3):202-6
Abstract: To compare diagnoses made from conventional microscopy and digitized imaging in preparation for teleconsultation cytopathology services that are affordable and efficient.
T Nagashima, M Suzuki, N Nakajima
Cytologic morphometric approach for the prediction of lymph node involvement in papillary thyroid cancer
1997 Feb;19(1):49-54
Abstract: Papillary thyroid cancer frequently metastasizes to lymph nodes; however, it is generally difficult to make a precise diagnosis preoperatively. The present study was carried out to evaluate lymph node status preoperatively by using quantitative estimations of various cytologic features obtained by fine needle aspiration biopsy from 110 patients with papillary thyroid cancer.
J D Forte, B P Croker, J B Hendricks
Comparison of histologic and cytologic specimens of urothelial carcinoma with image analysis. Implications for grading
Comparative Study: 1997 Apr;19(2):158-66
Abstract: To compare DNA results obtained by each of three preparation types (cytologic smears or cytocentrifuge samples, tissue sections and nuclei extracted from paraffin-embedded tissue) on patients with primary urothelial cell carcinoma of the bladder.
J P Chaudhuri, A Reith
Symmetric chromosomal order in leukocytes indicated by DNA image cytometry and fluorescence in situ hybridization
1997 Feb;19(1):30-6
Abstract: To study if the symmetry observed in the nuclear structure of polymorphonuclear cells (PNC) could be verified functionally by determining DNA and chromosome distributions using image cytometry (ICM) and fluorescence in situ hybridization (FISH) STUDY DESIGN: In murine and human leukocytes the proportion of PNCs with apparently bilaterally symmetric nuclei was determined. By ICM, total nuclear DNA and DNA content in each half of these nuclei were measured. For chromosomal localization the FISH technique was applied.
T Takubo, N Tatsumi
Distribution of myosin and actin in moving human neutrophils detected by double-fluorescence staining
1997 Jun;19(3):233-8
Abstract: To observe the distribution of myosin and actin in the same phase in the same human neutrophils with a double-fluorescence staining procedure that readily evaluates the association of myosin and actin in human neutrophils during movement.
I Ruschenburg, T Schlott, B Linke, S Reimer, M Droese
Automated molecular genetic DNA analysis for detecting B-cell non-Hodgkin's lymphoma in cytologic specimens
1997 Jun;19(3):255-63
Abstract: In fine needle aspiration cytology, conventional morphologic and immunocytologic criteria are often insufficient for distinguishing the mixed type of follicular lymphoma (NHL) from reactive lymphoid hyperplasia (RLH). For improving cytodiagnosis, we adapted computer-assisted polymerase chain reaction (PCR) assays on cytologic specimens. These novel techniques aim at fluorescence-based sequencing and sizing of PCR products that result from NHL-specific markers, such as the chromosomal t(14;18) (q32;q21) translocation and the CDR3 regions of expanded B-cell neoplasia.
C J Clem, D König, J P Rigaut
A three-dimensional dynamic simulation model of epithelial tissue renewal
1997 Apr;19(2):174-84
Abstract: Based on the study of existing simulation and mathematical models, a dynamic simulation and three-dimensional (3-D) visualization model of the normal and pathologic architecture of the nasal epithelium is proposed.
D Słowińska-Klencka, M Klencki, S Sporny, A Lewiński
Karyometric analysis in the cytologic diagnosis of thyroid lesions
1997 Dec;19(6):507-13
Abstract: To assess the possible role of karyometry in improving the diagnostic value of fine needle aspiration biopsy (FNAB) of the thyroid.
J A Freed
Possibility of correcting image cytometric nuclear DNA (ploidy) measurements in tissue sections. Insights from computed corpuscle sectioning and the reference curve method
1997 Oct;19(5):376-86
Abstract: To describe, validate and apply a computer simulation of corpuscle sectioning to determine which assumptions are compatible with the possibility of correction.
K Friedrich, B Thieme, G Haroske, W Meyer, V Dimmer, F Theissig, K D Kunze
Nuclear image analysis of p53-positive and -negative cells in breast carcinoma
1997 Aug;19(4):285-93
Abstract: To detect differences in nuclear morphology in breast carcinoma cells with different p53 expression.
H U Kasper, G Haroske, U Geissler, W Meyer, K D Kunze
Diagnostic and prognostic relevance of malignancy-associated changes in cervical smears
1997 Dec;19(6):482-8
Abstract: For approximately 15 years, malignancy-associated changes (MACs) have been consistently found by means of high-resolution cytometry in different tissues, especially in visually normal appearing cervical cells. Their biologic nature is not yet fully understood. The aim of this investigation was to assess the expression of MACs in cervical smears and to evaluate their prognostic relevance.
J Azúa, P Romeo, J Valle, J Azúa Jr
Cytologic differentiation grade and malignancy DNA index in prostatic adenocarcinoma
1997 Apr;19(2):102-6
Abstract: To compare the predictive value of cytologic differentiation grades traditionally used for adenocarcinoma of the prostate with the malignancy grades obtained by DNA quantification.
A Gschwendtner, T Mairinger
DNA measurement on histologic slides. Does it work on human tissue?
1997 Aug;19(4):294-300
Abstract: To determine the performance of different mathematical methods of correcting histograms obtained by densitometric DNA measurement on thin tissue sections for cutting artifacts in different types of human tissue.

Volume 13 (1997) Issue 1 - Issue 6

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